Combined Medical Treatment Of Chronic Pancreatitis

Abstract

The aim of the study was to determine the most effective medical treatment of patients with chronic pancreatitis, by using either pancreatin alone or in combination with proton pump inhibitor (PPI) or PPI and non-steroidal anti-inflammatory drug (NSAID). Patients with chronic pancreatitis, who did not require a surgical treatment, received medical treatment for a one–month period: 20 patients received pancreatin monotherapy; 48 patients were given a combination of pancreatin and PPI; 38 patients were treated with a combination of pancreatin, PPI and NSAID (PNP therapy group). In comparison with other groups, patients in the PNP therapy group showed improvement in body mass index, abdominal pain, bowel movements, chronic pancreatitis severity, as well as their quality of life assessment (p< 0.05). The combination of pancreatin, PPI and NSAID was the most effective among those applied in chronic pancreatitis patient treatment. A one–month long course of this therapy was safe and did not cause any significant adverse effects. The combination of pancreatin, PPI and NSAID for treatment of chronic pancreatitis can be recommended, as it is based on pathogenesis of the disease, effective, safe and economically advantageous.

Assessment of Chronic Pancreatitis Course Severity and Combined Medical Treatment Using Pancreatin, Proton Pump Inhibitor and Non-Steroidal Anti-Inflammatory Drug. Summary of the Doctoral Thesis

“…On 22.02.2012 VPI was registered as an invention in Patent office of the Republic of Latvia (patent Nr. LV 14515 B) named "Method of defining indications to surgical interference in case of chronic pancreatitis" [38].…”

“…In Considering this, VPI can be useful in assessing the indications of the surgical intervention in the case of CP. On February 22, 2012, the VPI was registered as the patent of the Republic of Latvia -"The surgical intervention indications assessment method in the case of chronic pancreatitis" (LV 14515 B) [38]. The VPI is an informative, safe, and easy to reproduce method that does not require invasive investigation and the hospitalization of a patient.…”

“…2 The usefulness of VPI for the choice of surgical intervention in case of CP was assessed. On the 22nd of February, 2012, VPI was registered as the patent of the Republic of Latvia -"The surgical intervention indications assessment method in the case of chronic pancreatitis" (LV 14515 B)[38].…”