Combined microfluidics and drying processes for the continuous production of micro-/nanoparticles for drug delivery: a review

Patil, Ankit; Patil, Pritam; Pardeshi, Sagar R.; Shrimal, Preena; Rebello, Norma; Mohite, Popat; Chatterjee, Aniruddha; Mujumdar, Arun S.; Naik, Jitendra

doi:10.1080/07373937.2023.2167827

Cited by 11 publications

(3 citation statements)

References 190 publications

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“…Organic ligands, including thiolates, phosphines, and alkynyls, are commonly used to coat the surfaces of certain gold (Au) NCs and silver NCs (AgNCs) to inhibit aggregation and aid in their separation. These ligands affect the mechanisms through which Au NCs and AgNCs develop, but they also have a consequence influence on the sizes, shapes, and final characteristics of these particles [8][9][10][11][12][13][14][15][16].…”

Section: Fundamentals Of Metal Nanoclustersmentioning

confidence: 99%

Updated Review on Recent Advances in Silver Nanoclusters in Bioanalytical and Biomedical Applications

Kshatriya,

Kumbhare,

Jadhav

et al. 2024

BIOI

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Silver nanoclusters (AgNCs) have emerged as highly adaptable nanomaterials with vast potential in theranostic applications, by integrating therapeutic and diagnostic capabilities within a single platform. This review summarizes current developments in the synthesis, characterization, and use of AgNCs for theranostics. AgNC synthesis has substantially advanced, and a variety of techniques such as chemical reduction, green synthesis, and templated methods are being used to manage stability, size, and form. AgNCs’ optical characteristics, including high fluorescence and surface-enhanced Raman scattering (SERS) signals, make them ideal for bioimaging and diagnostic applications. Furthermore, AgNCs’ surface chemistry enables simple functionalization with therapeutic drugs and targeting ligands, thus improving effectiveness and selectivity. AgNCs have been used in several diagnostic imaging modalities, including photoacoustic imaging, fluorescence imaging, and SERS-based sensing. They are suitable for both in vitro and in vivo imaging applications because of their exceptional photostability and biocompatibility, which enables real-time tracking of disease progression and therapy response.

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Section: Fundamentals Of Metal Nanoclustersmentioning

confidence: 99%

Updated Review on Recent Advances in Silver Nanoclusters in Bioanalytical and Biomedical Applications

Kshatriya,

Kumbhare,

Jadhav

et al. 2024

BIOI

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“…Patil et al [175] The article introduced diverse applications of microfluidic systems for precisely synthesizing organic and inorganic nanoparticles with controlled sizes. It discussed micromixers and their recent developments in drug delivery systems.…”

Section: References Descriptionsmentioning

confidence: 99%

Novel polymer-based hydrogels of recent research in drug delivery for disease treatment related to SARS-CoV-2 virus

Hoc Thang,

Van Phuc,

Nhi

et al. 2024

Express Polym. Lett.

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The COVID-19 pandemic has presented an array of challenges and given rise to a spectrum of diseases and health issues [1]. Foremost among the challenges of the pandemic is the swift transmission of the SARS-CoV-2 virus [2]. Strategies to curb transmission encompass extensive vaccination campaigns [3], the implementation of public health measures like mask-wearing [4] and social distancing [4], and the promotion of hygiene practices such as frequent handwashing [5]. The SARS-CoV-2 virus, which causes COVID-19, primarily targets the respiratory system [6]. However, it can also precipitate various complications and impact other organs and bodily systems [7]. COVID-19, an abbreviation for Coronavirus Disease 2019, is the ailment brought about by the SARS-CoV-2 virus [8]. It manifests as a broad spectrum of symptoms, spanning from mild to severe respiratory ailments [9]. Common symptoms include fever, cough, shortness of breath, fatigue, loss of taste or smell, and body aches [10]. In severe instances, it can progress to pneumonia and acute

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“…Al toxicity of TMCS/IgG-NP was expected [35,36], this was an encouragin provides the possibility of further studies in other cellular models, immu or even in vivo systems. In summary, the microfluidics of the continuous flow and the microemulsification methods, focusing on nanoparticle production for biomedicine applications, have been reported previously [9,[37][38][39]. Here, we successfully fabricate, from a reusable biopolymer such as chitosan, a derivative of chitin, CS, CS-IgG protein-loaded, and TMCS-IgG proteinloaded nanoparticles using the microfluidics assisted by an emulsification method.…”

Section: N-trimethyl Chitosan Chloride Nanoparticles Toxicity In Huma...mentioning

confidence: 99%

Chitosan, Chitosan/IgG-Loaded, and N-Trimethyl Chitosan Chloride Nanoparticles as Potential Adjuvant and Carrier-Delivery Systems

Tenorio-Barajas

Olvera²,

Romero-Paredes³

et al. 2023

Molecules

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This work proposes a feasible, reproducible, and low-cost modified method to manufacture chitosan, chitosan/IgG-protein-loaded, and trimethylated chitosan nanoparticles, using microfluidics combined with the microemulsion technique, which differs from the traditional batch process of chitosan-based nanoparticles. The synthesis process consists of generating microreactors of chitosan-based polymer in a poly-dimethylsiloxane ψ-shaped microfluidic device and then crosslinking with sodium tripolyphosphate outside the cell. Transmission electron microscopy demonstrates an improvement in size control and distribution of the solid-shape chitosan nanoparticles (~80 nm) compared to the batch synthesis. Regarding chitosan/IgG-protein-loaded nanoparticles, these presented a core-shell morphology having a diameter of close to 15 nm. Raman and X-ray photoelectron spectroscopies confirmed the ionic crosslinking between the amino groups of chitosan and the phosphate groups of sodium tripolyphosphate in the fabricated samples and the total encapsulation of IgG protein during the fabrication of chitosan/IgG-loaded nanoparticles. Then, an ionic crosslinking and nucleation-diffusion process of chitosan-sodium tripolyphosphate was carried out during the nanoparticle formation, with and without IgG protein loading. The use of N-trimethyl chloride chitosan nanoparticles in vitro on human-keratinocyte-derived cell line HaCaT did not show side effects independently of its concentration from 1 to 10 μg/mL. Therefore, the proposed materials could be used as potential carrier-delivery systems.

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Combined microfluidics and drying processes for the continuous production of micro-/nanoparticles for drug delivery: a review

Cited by 11 publications

References 190 publications

Updated Review on Recent Advances in Silver Nanoclusters in Bioanalytical and Biomedical Applications

Updated Review on Recent Advances in Silver Nanoclusters in Bioanalytical and Biomedical Applications

Novel polymer-based hydrogels of recent research in drug delivery for disease treatment related to SARS-CoV-2 virus

Chitosan, Chitosan/IgG-Loaded, and N-Trimethyl Chitosan Chloride Nanoparticles as Potential Adjuvant and Carrier-Delivery Systems

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