Combined modalities of magnetic resonance imaging, endoscopy and computed tomography in the evaluation of tumor responses to definitive chemoradiotherapy in esophageal squamous cell carcinoma

Qiu, Bo; Wang, De Ling; Yang, Hong; Xie, Wei; Liang, Ying; Cai, Peiqiang; Chen, Zhao Lin; Liu, Meng Zhong; Fu, Jianhua; Xie, Chuan; Liu, Hui

doi:10.1016/j.radonc.2016.09.017

Cited by 18 publications

(18 citation statements)

References 32 publications

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“…Both of them are closer to the GTVp than the GTV MRI and GTV CT . Both the CT and MRI methods are the first imaging choice for the staging of nasopharyngeal carcinoma [34,36,37]. The results of many studies show that diagenetic accuracy of CT and MRI are equal in the detection of abdominal lymph node metastasis, intraluminal mass and pericardial effusion [38,39].…”

Section: Discussionmentioning

confidence: 99%

Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models

Xiang¹,

Imani²,

Hu³

et al. 2020

J. Cancer

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Background:To determine the optimum conditions for diagnosis of nasopharyngeal carcinoma, we established VX2 rabbit model to delineate gross target volume (GTV) in different imaging methods. Methods: The orthotopic nasopharyngeal carcinoma (NPC) was established in sixteen New Zealand rabbits. After 7-days inoculation, the rabbits were examined by CT scanning and then sacrificed for pathological examination. To achieve the best delineation, different GTVs of CT, MRI, 18 F-FDG PET/CT, and 18 F-FLT PET/CT images were correlated with pathological GTV (GTVp). Results:We found 45% and 60% of the maximum standardized uptake value (SUV max ) as the optimal SUV threshold for the target volume of NPC in 18 F-FDG PET/CT and 18 F-FLT PET/CT images, respectively (GTV FDG45% and GTV FLT60% ). Moreover, the GTV MRI and GTV CT were significantly higher than the GTVp (P ≤ 0.05), while the GTV FDG45% and especially GTV FLT60% were similar to the GTVp (R = 0.892 and R = 0.902, respectively; P ≤ 0.001). Conclusions: Notably, the results suggested that 18 F-FLT PET/CT could reflect the tumor boundaries more accurately than 18 F-FDG PET/CT, MRI and CT, which makes 18 F-FLT PET-CT more advantageous for the clinical delineation of the target volume in NPC.

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Section: Discussionmentioning

confidence: 99%

Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models

Xiang¹,

Imani²,

Hu³

et al. 2020

J. Cancer

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“…Notably, few published studies have investigated the clinical value of DWI in evaluating esophageal carcinoma. Several studies have used “whole tumor” ROI data to differentiate malignant and benign nodes in esophageal carcinoma [ 10 , 11 ] and predict RT response [ 12 , 13 ]. Some groups have advocated assessment of only the most enhanced voxels within a tumor, based on the result that the most enhanced ROIs provided more statistically significant differences between responders and non-responders in CRT than whole tumor ROI [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Inter- and intra-observer reproducibility of ADC measurements in esophageal carcinoma primary tumors

Fang

Dai

et al. 2017

Oncotarget

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The apparent diffuse coefficient (ADC) may correlate with the treatment response to chemotherapy/radiotherapy in solid tumors. Our aim was to determine the inter- and intra-observer reproducibility of ADC measurements in primary esophageal squamous cell carcinoma (ESCC). ADCs were blindly measured in 31 patients diagnosed with ESCC by two observers before treatment (pre-ADC) and after 5th fraction radiotherapy (intra-ADC) twice with a 2-week interval. The mean pre-ADC of primary tumors was 1.25±0.22 and 1.27±0.23 (in 10−3mm2/s) from observer A for measurements 1 and 2, respectively, and the intra-observer measurements were -0.02 bias vs. -0.13-0.09 limits of agreement. From observer B, the mean pre-ADC varied between 1.25±0.23 and 1.27±0.23 (in 10−3mm2/s) for measurements 1 and 2, respectively, and intra-observer measurements were -0.02 bias vs. -0.17∼0.16 limits of agreement. The mean pre-ADC of primary tumors was 1.26±0.24 (in 10−3mm2/s) from observers A and B, and inter-observer measurements were 0.01 bias vs. -0.09-0.09 limits of agreement, revealing a low inter-observer variance. Similar measurements of the intra-SD parameters showed that the pre- and intra-ADC of primary tumors differed significantly. Thus ADC measurements may have sufficient inter-observer and intra-observer reproducibility to measure primary tumor responses to treatment, and the ADCs before and during treatment differed.

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“…Concurrent chemoradiotherapy (CRT) should be considered for cervical and upper thoracic esophageal cancer (5). Locally advanced esophageal cancer is managed with nCRT, definitive chemoradiotherapy (dCRT), perioperative chemotherapy (for EAC), or esophagectomy (5,43). The use of nCRT in locally advanced esophageal cancer is associated with improved OS and pathological complete response (pCR) (44).…”

Section: Treatmentmentioning

confidence: 99%

Role of precision imaging in esophageal cancer

Elsherif¹,

Andreou²,

Virarkar³

et al. 2020

J Thorac Dis

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Esophageal cancer is a major cause of morbidity and mortality worldwide. Recent advancements in the management of esophageal cancer have allowed for earlier detection, improved ability to monitor progression, and superior treatment options. These innovations allow treatment teams to formulate more customized management plans and have led to an increase in patient survival rates. For example, in order for the most effective management plan to be constructed, accurate staging must be performed to determine tumor resectability. This article reviews the multimodality imaging approach involved in making a diagnosis, staging, evaluating treatment response and detecting recurrence in esophageal cancer.

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Combined modalities of magnetic resonance imaging, endoscopy and computed tomography in the evaluation of tumor responses to definitive chemoradiotherapy in esophageal squamous cell carcinoma

Cited by 18 publications

References 32 publications

Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models

Comparison of different images in gross target volume delineating on VX2 nasopharyngeal transplantation tumor models

Inter- and intra-observer reproducibility of ADC measurements in esophageal carcinoma primary tumors

Role of precision imaging in esophageal cancer

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