Combined Modality Therapy for Locally Advanced Penile Squamous Cell Carcinoma

Pedrick, Thomas J.; Wheeler, Warren L.; Riemenschneider, Herbert W.

doi:10.1097/00000421-199312000-00009

Cited by 17 publications

(5 citation statements)

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“…14,22 Studies in a limited number of cases show the relative efficacy of combined 5-fluorouracil/cisplatin for pN3 or pelvic lymph node invasion with the possibility of salvage surgery when there is a response to chemotherapy. 23,24 One complete and 3 partial responses were noted in a total of 12 patients in a pilot study using combined vincristine, bleomycin and methotrexate. 25 Neoadjuvant chemotherapy was tested in 59 patients with locally advanced penile cancer, of whom 10 responded.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Followup of Penile Carcinoma With High Risk for Lymph Node Invasion Treated With Inguinal Lymphadenectomy

Marconnet¹,

Rigaud²,

Bouchot³

2010

Journal of Urology

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After inguinal lymphadenectomy specific and recurrence-free survival in cN1 and pN1 cases was comparable to that in cN0 and pN0 cases. The recurrence rate in the latter was higher than for other occult inguinal metastasis detection techniques. Only superomedial inguinal lymph nodes were studied, missing central and lateral superior zone occult metastasis. Survival was poor in patients with more than 2 lymph nodes invaded. In those cases chemotherapy protocols or chemotherapy combined with lymphadenectomy must be evaluated.

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Section: Discussionmentioning

confidence: 99%

Long-Term Followup of Penile Carcinoma With High Risk for Lymph Node Invasion Treated With Inguinal Lymphadenectomy

Marconnet¹,

Rigaud²,

Bouchot³

2010

Journal of Urology

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“…Experience with SCC in the head and neck, anus, and cervix has shown promising results with concomitant radiation therapy, but hardly any experience has been gathered in SCC of the penis [73][74][75].…”

Section: Chemotherapymentioning

confidence: 99%

Contemporary management of penile squamous cell carcinoma

2004

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Squamous cell carcinoma (SCC) is the most common tumor of the penis. The natural history and its proclivity to spread via regional lymphatics has been well defined. Laser ablation of the primary tumor has a prominent role in patients with a superficial tumor as a penis-conserving approach. Patients with deeper infiltrating tumors, should undergo (partial) penile amputation. For patients presenting with proven metastatic nodes complete (ilio-) inguinal lymphadenectomy should be performed. During the last two decades, the management of penile carcinoma patients with impalpable regional lymph nodes has improved due to better knowledge of risks for metastases, the introduction of modified lymphadenectomy, and sentinel node biopsy. Future perspectives in penile cancer comprises continuing research to reduce mutilation without jeopardizing clinical outcome.

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“…Hussein et al [16] reported that a novel chemotherapeutic combination (CDDP and 5-FU) achieved partial responses in five of six patients (five cases of penile cancer and one of SCC of the urethra). In SCC of the anus or larynx, combination therapy, multiagent chemotherapy, and surgery or radiation therapy resulted in improved outcomes [17,18]. In the case described in this report, we predicted a very poor prognosis given the existing inguinal and intrapelvic lymph node metastases at the initial visit.…”

Section: Discussionmentioning

confidence: 80%