Combined naevus: a benign lesion frequently misdiagnosed both clinically and pathologically as melanoma

Scolyer, Richard A.; Zhuang, Liqing; Palmer, A. W.; Thompson, John F.; McCarthy, Stanley W.

doi:10.1080/00313020412331283879

Cited by 71 publications

(60 citation statements)

References 30 publications

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“…Richard et all. have examined 180 cases of combined nevi and reported that the most common combination was a common acquired nevus of compound type with a blue nevus (2). In our case, histopathological examination revealed features of junctional nevi at dermoepidermal junction and blue nevi in the dermis, that corresponded to features seen on dermatoscopy.…”

Section: Discussionsupporting

confidence: 62%

“…In our case, histopathological examination revealed features of junctional nevi at dermoepidermal junction and blue nevi in the dermis, that corresponded to features seen on dermatoscopy. Only 5 cases of common acquired nevus of junctional type associated with blue nevus were observed in the previously reported study (2).…”

Section: Discussionmentioning

confidence: 80%

“…These are uncommon lesions, accounting for less than 1% of all biopsied nevi (1,2). Epidemiologically, they are most commonly seen in children and young adults, but they may occur at any age and in both sexes (1).…”

Section: Introductionmentioning

confidence: 99%

“…Accurate clinical diagnosis is made only in 2.4% of all cases, whereas melanoma and dysplastic nevi are most frequent preoperative diagnoses (2).…”

Section: Introductionmentioning

confidence: 99%

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Dermoscopy Case of the Month Combined Nevus - a Case Report

Jović

Vidović

Popović

et al. 2017

Serbian Journal of Dermatology and Venereology

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Combined nevi are melanocytic lesions composed of two or more distinct types of melanocytic populations within the same lesion. Different types of combined nevi may form bizarrely shaped, multicolored skin lesions, making them one of the greatest melanoma mimickers. We report a 48-year-old female patient with suspicious skin lesion in the left lumbar region. Clinically, there was an oval, slightly asymmetrical lesion measuring 6 x 4 mm, showing multiple colors and shades of brown and black. A dermoscopic examination revealed a brown-bluish coloration in the right part of the lesion, while a fine pigment network with perifollicular halo was found in the left part of the lesion, suggesting the diagnosis of a combined nevus. Histological examination showed a poorly circumscribed proliferation of dendritic melanocytes in the superficial and deep dermis and proliferation of melanocytes in the dermoepidermal junction. A surgical excision of the tumor was performed, in order to confirm the dermoscopic findings. In conclusion, dermoscopy is useful in differentiating combined nevi from other melanocytic lesions.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

“…Accurate clinical diagnosis is made only in 2.4% of all cases, whereas melanoma and dysplastic nevi are most frequent preoperative diagnoses (2).…”

Section: Introductionmentioning

confidence: 99%

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Dermoscopy Case of the Month Combined Nevus - a Case Report

Jović

Vidović

Popović

et al. 2017

Serbian Journal of Dermatology and Venereology

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“…Scolyer, et al 32 recently underscored that a correct clinical diagnosis of combined nevus was given only in 2.4% of their cases. On the other hand, De Giorgi, et al 33 stated that dermoscopy can provide useful information for a conservative management of combined nevi, at least when a clear-cut blue nevus component is present.…”

Section: Discussionmentioning

confidence: 99%

The many faces of blue nevus: A clinicopathologic study

et al. 2006

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Background: In recent years, several histopathologic variants of blue nevus have been identified, whose clinical and dermoscopic correlates need further clarification. Methods: A comparative evaluation of histopathologic and dermoscopic features was carried out on 52 melanocytic proliferations belonging to the morphologic spectrum of blue nevus. Results: On dermoscopy, all lesions showed a homogeneous, structureless pigment pattern, with a curious variety of colors (blue, white-blue, black, brown, and polychromatic). Histopathologically, the majority of blue lesions were common blue nevi (11/19); the majority of white-blue lesions were Ôhypochromic' (sclerotic, hypomelanotic, and amelanotic) blue nevi (17/22); all the black lesions were Ôcompound' blue nevi (2/2); the majority of brown lesions were combined blue nevi (3/4); the unusual polychromatic dermoscopic appearance was often associated with a histopathologic diagnosis of deep penetrating nevus (2/5). Conclusion: A dermoscopic-pathologic approach now allows us to identify Ôblue' (common) blue nevi, Ôwhite' (hypochromic) blue nevi, Ôblack' (compound) blue nevi, Ôbrown' (combined) blue nevi, and Ôpolychromatic' (deep penetrating) blue nevi. A better recognition of the many dermoscopic faces of blue nevi is expected to give a morphologic guideline for the clinical management of these lesions. Ferrara G, Soyer HP, Malvehy J, Piccolo D, Puig S, Sopena J, Zalaudek I, Argenziano G. The many faces of blue nevus: A clinicopathologic study.

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