Combined non-thrombogenic and endothelial cell adhesive surfaces by a single step procedure

Gabriel, Manal M.; Weiler, Hartmut; Mehlhorn, Uwe; Vahl, C.-F.

doi:10.1055/s-0034-1367270

Cited by 1 publication

(1 citation statement)

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“…Nevertheless, the generated endothelium fails to completely cover the neointima, which contributes to thrombus formation [55] . Thus, the biostable polymers require surface modification and bioactive molecular incorporation to improve EC confluence on the material surface [56] .…”

Section: Blood Interface Of Vascular Graftsmentioning

confidence: 99%

Tissue Engineering at the Blood‐Contacting Surface: A Review of Challenges and Strategies in Vascular Graft Development

Radke

Jia

Sharma

et al. 2018

Adv Healthcare Materials

213

166

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Tissue engineered vascular grafts (TEVGs) are beginning to achieve clinical success and hold promise as a source of grafting material when donor grafts are unsuitable or unavailable. Significant technological advances have generated small-diameter TEVGs that are mechanically stable and promote functional remodeling by regenerating host cells. However, developing a biocompatible blood-contacting surface remains a major challenge. The TEVG luminal surface must avoid negative inflammatory responses and thrombogenesis immediately upon implantation and promote endothelialization. The surface has therefore become a primary focus for research and development efforts. The current state of TEVGs is herein reviewed with an emphasis on the blood-contacting surface. General vascular physiology and developmental challenges and strategies are briefly described, followed by an overview of the materials currently employed in TEVGs. The use of biodegradable materials and stem cells requires careful control of graft composition, degradation behavior, and cell recruitment ability to ensure that a physiologically relevant vessel structure is ultimately achieved. The establishment of a stable monolayer of endothelial cells and the quiescence of smooth muscle cells are critical to the maintenance of patency. Several strategies to modify blood-contacting surfaces to resist thrombosis and control cellular recruitment are reviewed, including coatings of biomimetic peptides and heparin.

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Section: Blood Interface Of Vascular Graftsmentioning

confidence: 99%