Combined Nonablative Skin Rejuvenation with the 595- and 1450-nm Lasers

Trelles, Mario A.; Allones, Inés; Levy, Jean Luc; Calderhead, R Glen; Moreno‐Arias, Gerardo A.

doi:10.1111/j.1524-4725.2004.30405.x

Cited by 41 publications

(30 citation statements)

References 35 publications

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“…In addition, these shorter pulse durations may have different results than pulse-durations of 6 milliseconds and longer on fine lines and wrinkles, and enlarged pores. In patients with fine lines and wrinkles, enlarge pores, acne, and acne scarring, the PDL is often combined with an infrared laser such as the 1,450 nm laser, during the same treatment session [15,16]. The addition of the second laser appears to result in greater improvement in rhytides and acne than either laser alone [15,16].…”

Section: Discussionmentioning

confidence: 99%

“…In patients with fine lines and wrinkles, enlarge pores, acne, and acne scarring, the PDL is often combined with an infrared laser such as the 1,450 nm laser, during the same treatment session [15,16]. The addition of the second laser appears to result in greater improvement in rhytides and acne than either laser alone [15,16]. Future studies to further optimize treatment parameters for a variety of skin types and conditions, should enable even more consistent improvement in photodamaged skin using the PDL, which has a long history of safety and efficacy in treating a myriad of cutaneous conditions.…”

Section: Discussionmentioning

confidence: 99%

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The new‐generation, high‐energy, 595‐nm, long pulse‐duration pulsed‐dye laser improves the appearance of photodamaged skin

Bernstein

2007

Lasers Surg Med

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Background and Objectives: Chronic sun-exposure results in five main changes to exposed skin: telangiectasia, hyperpigmentation, rhytides, enlarged pores, and sagging skin. Various laser and non-laser modalities have been used to improve sun-damaged skin. The pulsed-dye laser (PDL) has an unparalleled safety record and an ideal wavelength for treating the signs of photodamage. In this study, we investigate the ability of the long pulse-duration PDL to improve the appearance of photodamaged skin. Study Design/Materials and Methods: Ten subjects with cutaneous photodamage were treated with the highenergy, long pulse-duration PDL using fluences ranging from 8.0 to 10.0 J/cm 2 , a 10-mm spot, and a 10-millisecond pulse-duration. Five subjects judged to have discrete solar lentigos or ephiledes were also treated to these lesions using a compression handpiece. Improvement was determined by blinded evaluation of photographs taken before and after the final treatment, and by subjects' selfevaluation 8 weeks following the final treatment. Results: Subjects rated overall improvement as 65%, facial veins as 72% improved, hyperpigmentation 65% improved, enlarged pores 65% improved, and wrinkles 62% improved. Improvement was also determined by 3 physicians rating digital photographs and blinded as to which photos were pre-or post-treatment. They rated wrinkles as improved in 50% of photographs, veins as improved in 82%, diffuse redness as improved in 80%, pigmentary alterations as improved in 61.4%, and pore size as improved in 25%. Conclusions: The high-energy, long pulse-duration PDL improves photodamaged skin using non-purpuric settings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The new‐generation, high‐energy, 595‐nm, long pulse‐duration pulsed‐dye laser improves the appearance of photodamaged skin

Bernstein

2007

Lasers Surg Med

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“…The very good histological evidence of tightening of the typically elastotic dermis failed to be echoed in a younger-looking epidermis, and patient satisfaction with single modality non-ablative skin rejuvenation was extremely low (7)(8)(9)(10). The combination of single modality systems based on wavelength-specific photobiological precepts produced much better visible results (11)(12)(13).…”

Section: Viewpointmentioning

confidence: 99%

“…Elimination of oxidized proteins is mainly achieved through degradation by the proteasomal system (6,7) while certain oxidative protein modifications such as oxidation of methionine residues can be reversed within proteins by the methionine sulfoxide reductases (Msrs) system which represents one of the few repair mechanisms for oxidized proteins (8)(9)(10). Both systems have been documented to generally exhibit an age-related decline (11)(12)(13), notably for the proteasome in human epidermal cells and dermal fibroblasts (14)(15)(16)(17).…”

Section: Viewpointmentioning

confidence: 99%

Viewpoint 3

Trelles¹,

Mordon²,

Calderhead³

2008

Experimental Dermatology

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type I collagen in the dermis (16,36). These observations demonstrate the role of retinoids in both preventing and reversing the signs of UV-induced skin ageing.In conclusion, despite the vast array of 'antiageing' products now available topical retinoids and sunscreens remain the most tried and tested treatments with long established safety records and proven efficacy in the treatment and prevention of UV-induced skin ageing.Stephanie Ogden, Christopher EM Griffiths 13 Sendagorta E, Lesiewicz J, Armstrong R B. J Am Acad Dermatol 1992: 27: S15-S18. Viewpoint 3Excessive skin exposure to solar UV brings about detrimental histological changes in the skin, which combine with and accelerate the effects of chronological ageing, and which result in the lax, dull and wrinkled appearance of 'old' skin. UV photochemically generated oxidative stressors such as singlet oxygen damage matrix integrity; elastosis-inducing damage to the underlying connective tissue occurs, with interstitial spaces appearing in the matrix caused by loss of collagen volume and fibre binding; the viscosity and quality of the matrix ground substance glycosaminoglycans is reduced; and an inflammatory infiltrate can be identified (1).The elegant idea of using light to repair the damage caused by overexposure to light was heralded by the indication of first the CO 2 and the Er:YAG lasers in the early 1990s, (2-4) and then a system which combined both wavelengths in the one console (5,6). Although still regarded as the 'gold standard' in the rejuvenation of seriously photoaged skin, laser ablative resurfacing is simply a controlled second degree burn of the dermis and is associated with, at best, unpleasant side effects and a long downtime.A non-ablative approach using lasers and intense pulsed light (IPL) systems delivered a zone of controlled dermal photothermal damage under an intact epidermis to 'kickstart' the wound healing process recognized as essential in successful skin rejuvenation. The very good histological evidence of tightening of the typically elastotic dermis failed to be echoed in a younger-looking epidermis, and patient satisfaction with single modality non-ablative skin rejuvenation was extremely low (7-10). The combination of single modality systems based on wavelength-specific photobiological precepts produced much better visible results (11-13).Fractional photothermolysis was next proposed for skin rejuvenation (14,15), to bridge the gap between ablative and non-ablative technologies by delivering controlled microdamage to both the epidermis and dermis. Some good results have been reported, but patient satisfaction has again been fickle with fractional technology on its own,

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“…In addition, LLLT confers aesthetic benefits, including its effects on hair growth/regrowth [44][45][46][47][48], acne treatment, [49,50] and skin rejuvenation [51,52].…”

Section: Other Effectsmentioning

confidence: 99%

Biological Function of Low Reactive Level Laser Therapy (LLLT)

Kubota¹,

Ishihara²

2017

Photomedicine - Advances in Clinical Practice

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Low reactive level laser therapy (LLLT) and photobiomodulation are mainly focused on the activation of intracellular or extracellular photoabsorbable molecule (chromophore) and the initiation of cellular signaling using low power lasers and lights. Over the past 40 decades, a number of basic and clinical researches were reported that the laser therapy had the potential to improve wound healing and reduce pain and inflammation. In recent years, the term "LLLT" has become widely recognized. In this review, the mechanisms of action of LLLT at a cellular level are described. Finally, our recent research results that LLLT enhanced the cells differentiation are also described.

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Combined Nonablative Skin Rejuvenation with the 595- and 1450-nm Lasers

Abstract: Wavelengths of 595 plus 1450 nm for skin rejuvenation produced good results with much higher patient satisfaction than those obtained with the 595- or 1450-nm wavelengths alone.

Cited by 41 publications

References 35 publications

The new‐generation, high‐energy, 595‐nm, long pulse‐duration pulsed‐dye laser improves the appearance of photodamaged skin

The new‐generation, high‐energy, 595‐nm, long pulse‐duration pulsed‐dye laser improves the appearance of photodamaged skin

Viewpoint 3

Biological Function of Low Reactive Level Laser Therapy (LLLT)

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