2022
DOI: 10.1016/j.smrv.2022.101649
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Combined noradrenergic plus antimuscarinic agents for obstructive sleep apnea - A systematic review and meta-analysis of randomized controlled trials

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Cited by 10 publications
(7 citation statements)
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“…3 According to a recent report regarding ATO-OXY therapy, improvements of AHI were probably driven by an increase in the responsiveness of the upper airway dilator muscles. 10,11 The conceivable reasons for the inconsistency of our results with that of the previous study performed in the United States are (1) ethnic or phenotypic trait differences in OSA pathogenesis and (2) differences in ATO-OXY reactivity in Japanese patients. The most recent report regarding ATO-OXY therapy for patients with OSA revealed that the concomitant use of zolpidem, which improves the arousal threshold, enhanced sleep efficiency.…”
Section: Discussioncontrasting
confidence: 90%
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“…3 According to a recent report regarding ATO-OXY therapy, improvements of AHI were probably driven by an increase in the responsiveness of the upper airway dilator muscles. 10,11 The conceivable reasons for the inconsistency of our results with that of the previous study performed in the United States are (1) ethnic or phenotypic trait differences in OSA pathogenesis and (2) differences in ATO-OXY reactivity in Japanese patients. The most recent report regarding ATO-OXY therapy for patients with OSA revealed that the concomitant use of zolpidem, which improves the arousal threshold, enhanced sleep efficiency.…”
Section: Discussioncontrasting
confidence: 90%
“…OXY has been reported to potentially prevent the muscle contraction effect of acetylcholine on upper airway muscle tone 3 . According to a recent report regarding ATO–OXY therapy, improvements of AHI were probably driven by an increase in the responsiveness of the upper airway dilator muscles 10,11 . The conceivable reasons for the inconsistency of our results with that of the previous study performed in the United States are (1) ethnic or phenotypic trait differences in OSA pathogenesis and (2) differences in ATO–OXY reactivity in Japanese patients.…”
Section: Discussioncontrasting
confidence: 71%
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“…Afterwards, Dr. Elisa Perger presented two randomized controlled trials 32,33 that showed a significant reduction of AHI and hypoxic burden in OSA patients treated with a noradrenergic and antimuscarinic combination versus placebo. However, a recent meta-analysis 34 on the topic showed that further evidence on long-term safety and efficacy of this pharmacological combination in OSA patients is required.…”
Section: Sleep Disordered Breathing: New Pharmacological Perspectivesmentioning
confidence: 99%