Combined Oral Contraceptives in Women with Systemic Lupus Erythematosus

Petri, Michelle; Kim, Mimi Y.; Kalunian, Kenneth C.; Grossman, Jennifer; Hahn, Bevra H.; Sammaritano, Lisa R.; Lockshin, Michael D.; Merrill, Joan T.; Belmont, H. Michael; Askanase, Anca; McCune, W. Joseph; Hearth-Holmes, Michelene; Dooley, Mary Anne; Feldt, Joan Von; Friedman, Alan Warren; Tan, Mingjia; Davis, John C.; Cronin, Mary E.; Diamond, Betty; Mackay, Meggan; Sigler, Lisa; Fillius, Michael; Rupel, Ann; Licciardi, F.; Buyon, Jill P.

doi:10.1056/nejmoa051135

Cited by 1,023 publications

(724 citation statements)

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“…a structured interview and a review of medical files were used to gather clinical (disease duration, disease activity evaluated on the basis of the Selena-Sledai index (Safety of estrogen in lupus erythematosus national assessment -Systemic lupus erythematosus disease activity index)) [14] and sociodemographic data. the present study obtained the approval of the independent Bioethics commission for research of medical university in Gdansk.…”

Section: Methodsmentioning

confidence: 99%

Learned helplessness and its associations with illness perception, depression and anxiety among patients with systemic lupus erythematosus

Nowicka-Sauer¹,

Hajduk²,

Kujawska-Danecka³

et al. 2017

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Background. Systemic lupus erythematosus (Sle) is a chronic, multi-organ disease that significantly impacts patients' psychological functioning. learned helplessness (lH) and illness perception have been proven to influence patients' emotional and physical state and treatment adherence. Objectives. the study is aimed at exploring learned helplessness and its relationship with illness perception, depression and anxiety among patients with Sle. Material and methods. the participants were 59 outpatients diagnosed with Sle (55 women, mean age: 45.0 ± 11.7 years; mean Sle duration 11.1 years). the rheumatology Helplessness index (rHi), Brief illness Perception Questionnaire (B-iPQ), Hospital anxiety and depression Scale (HadS) were used. a structured interview and a review of medical files were used to gather clinical and sociodemographic data. Results. learned helplessness was significantly positively correlated with the illness perception total score (r = 0.609), as well as illness consequences (r = 0.432), identity (r = 0.385), concern (r = 0.473) and emotional response (r = 0.543). depression and anxiety levels were also significantly correlated with lH (r = 0.588 and r = 0.472, respectively). no significant associations were observed between lH and age, age at diagnosis, duration of the disease, disease activity, gender, education and employment status. Conclusions. 1. in patients with Sle, learned helplessness is related to experiencing more severe consequences and symptoms of Sle, as well as more intense concerns and negative emotions related to the disease. 2. Psychotherapeutic intervention aimed at patient empowerment and modification of negative cognitions seems vital in order to diminish negative psychological functioning. 3. treatment and self-management aimed at better symptoms control and minimizing the consequences of illness may contribute to less negative cognitive and emotional illness representations.

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Section: Methodsmentioning

confidence: 99%

Learned helplessness and its associations with illness perception, depression and anxiety among patients with systemic lupus erythematosus

Nowicka-Sauer¹,

Hajduk²,

Kujawska-Danecka³

et al. 2017

fmpcr

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“…After menopause, flares of lupus tend to subside and the number of new cases substantially decreases [11]. The safety of oral contraceptives and hormone-replacement therapy for women with stable or moderate SLE disease has been reported, in the USA, by the Safety of Estrogens in Lupus Erythematosus-National Assessment [12] and by a similar study completed in Mexico [13]. The results from those trials suggest that patients with Table 17.1 Biased autoimmune diseases.…”

Section: Oestrogen and Autoimmunitymentioning

confidence: 99%

Hormones: Epigenetic Contributors to Gender‐Biased Autoimmunity

Rider

Abdou²

2009

The Epigenetics of Autoimmune Diseases

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“…It is conjectured that hormonal, environmental, genes, genetic variation and heredity play a significant role in its development [12]. It has been seen that if one member of a twin is affected the chances that the other twin may also be affected is 24%.…”

Section: Historical Perspective and Physiologymentioning

confidence: 99%