Combined pentalogy of Cantrell with ectrodactyly and surgical implant‐free repair of a sternal cleft and supraumbilical hernia in an adult cat

Kokkinos, Panagiotis; Pratschke, Kathryn

doi:10.1002/vrc2.364

Cited by 2 publications

(3 citation statements)

References 22 publications

(68 reference statements)

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“…Findings from publications that have reported either complete or incomplete POC in domestic animals are summarized (shown in Table 1 ). The total number of POC cases in domestic animals comprised 1 calf [ 15 ], 10 dogs [ 16 , 17 , 18 , 19 , 20 ], 2 cats [ 21 , 22 ] and 6 piglets [ 23 ]. Except for the stillborn piglets, all other reports are of live cases.…”

Section: Resultsmentioning

confidence: 99%

“…Except for the stillborn piglets, all other reports are of live cases. Complete class I POC was reported in one cat [ 21 ], four dogs [ 17 , 18 ] and all of the described piglets ( n = 6) [ 23 ]. Of the four previously published canine case reports that specified gender [ 16 , 18 , 19 , 20 ], the four dogs with POC were male (three German shepherds and one border terrier).…”

Section: Resultsmentioning

confidence: 99%

“…Together with our 2 cases, a total of 9 out of 12 known canine cases were males. No gender bias was observed in the other reported veterinary species [15,[21][22][23]. Information regarding the familial history and siblings was only provided for the affected calf and piglets.…”

Section: Literature Review Of Poc In Domestic Animalsmentioning

confidence: 99%

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Pentalogy of Cantrell in Two Neonate Littermate Puppies: A Spontaneous Animal Model Suggesting Familial Inheritance

Donahoe

Podadera

et al. 2023

Animals

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Developmental anomalies are an important cause of stillbirth and early perinatal death in companion animals. Many of these disorders remain poorly understood and provide an opportunity as a spontaneous animal model for human disease. Pentalogy of Cantrell is a rare congenital syndrome described in human neonates. It is a ventral midline closure defect with a proposed familial inheritance in humans. This syndrome involves five defects, including the thoracoabdominal wall, sternal, diaphragmatic, pericardial and cardiac malformations. Diverse expressions of these defects have been described in humans and sporadically in domestic animals. This severe syndrome commonly harbors a poor prognosis, posing an ethical and surgical dilemma. To better understand this syndrome and its presentation in dogs, we describe two rare cases of Pentalogy of Cantrell in a litter of papillon dogs. The affected puppies had anomalies compatible with the Pentalogy of Cantrell, including thoracoabdominal schisis, ectopia cordis, sternal cleft, pericardial agenesis, and diaphragmatic defects. The diagnosis was confirmed by advanced imaging (computed tomography) and postmortem examinations. The family history of this litter was explored and other cases in domestic animals were reviewed. This is the first report of the complete Pentalogy of Cantrell with ectopia cordis in the dog and the only report on papillons. Similar to human cases, possible familial inheritance and suspected male gender bias were observed. Further research on this novel animal model, its pathogenesis and its hereditary basis, may be helpful in better understanding this rare developmental disorder.

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