Combined photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source

Lee, Chang-Ho; Han, Sun Kyung; Kim, Sehui; Jeon, Mansik; Jeon, Min Yong; Kim, Chulhong; Kim, Jeehyun

doi:10.1364/ao.52.001824

Cited by 70 publications

(54 citation statements)

References 27 publications

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“…Several different implementations of OCT/PAM dual-modality imaging system have been introduced since 2009, including an SD OCT system combined with a transmission mode OR-PAM system, 229 an SD OCT system combined with a laser scanning optical resolution PAM (LSOR-PAM) system, 230 and a dual-modality system in which OCT and PAM use the same NIR supercontinuum laser source 231 or the same visible laser source. 232 Two representative designs are given in Figs.…”

Section: Implementations Of Dual-modality Oct/photoacoustic Imaging Smentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

433

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Implementations Of Dual-modality Oct/photoacoustic Imaging Smentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

433

264

View full text Add to dashboard Cite

show abstract

“…1. Although photoacoustic microscopy (PAM) and photoacoustic endoscopy (PAE) have been combined with OCT already [8][9][10][11][12][13][14][15][16], they either suffer from the shallow penetration depth of the optical resolution PAM (OR-PAM) systems or are still in the initial prototype stage with some fundamental challenges to tackle. Combining PAT and OCT, especially using the optical detection PAT, enables large field of view (FOV), whole-body imaging with centimeter level penetration depth achievable by PAT.…”

Section: Combined Pat/octmentioning

confidence: 99%

In vivo spectroscopic photoacoustic tomography imaging of a far red fluorescent protein expressed in the exocrine pancreas of adult zebrafish

Schmitner

Sandrian

et al. 2014

SPIE Proceedings

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Fluorescent proteins brought a revolution in life sciences and biological research in that they make a powerful tool for researchers to study not only the structural and morphological information, but also dynamic and functional information in living cells and organisms. While green fluorescent proteins (GFP) have become a common labeling tool, red-shifted or even near infrared fluorescent proteins are becoming the research focus due to the fact that longer excitation wavelengths are more suitable for deep tissue imaging. In this study, E2-Crimson, a far red fluorescent protein whose excitation wavelength is 611 nm, was genetically expressed in the exocrine pancreas of adult zebrafish. Using spectroscopic all optical detection photoacoustic tomography, we mapped the distribution of E2-Crimson in 3D after imaging the transgenic zebrafish in vivo using two different wavelengths. With complementary morphological information provided by imaging the same fish using a spectral domain optical coherence tomography system, the E2-Crimson distribution acquired from spectroscopic photoacoustic tomography was confirmed in 2D by epifluorescence microscopy and in 3D by histology. To the authors' knowledge, this is the first time a far red fluorescent protein is imaged in vivo by spectroscopic photoacoustic tomography. Due to the regeneration feature of zebrafish pancreas, this work preludes the longitudinal studies of animal models of diseases such as pancreatitis by spectroscopic photoacoustic tomography. Since the effective penetration depth of photoacoustic tomography is beyond the transport mean free path length, other E2-Crimson labeled inner organs will also be able to be studied dynamically using spectroscopic photoacoustic tomography.

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“…Thus, there is great interest among researchers in biomedical study to integrate di®erent imaging methods with the PAI system. [19][20][21][22][23][24] PA multi-modal imaging technology integrated with OCT, ultrasound imaging and°uorescence have been reported in the literature. [25][26][27] PA multi-modal imaging can simultaneously obtain parameters, such as absorption and scattering of biological tissue, which can provide powerful technical means for modern precision medical diagnosis.…”

Section: Introductionmentioning

confidence: 99%

All-optically integrated photoacoustic and optical coherence tomography: A review

Qiao

Chen

2017

J. Innov. Opt. Health Sci.

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All-optically integrated photoacoustic (PA) and optical coherence tomography (OCT) dualmode imaging technology that could o®er comprehensive pathological information for accurate diagnosis in clinic has gradually become a promising imaging technology in the aspect of biomedical imaging during the recent years. This review refers to the technology aspects of alloptical PA detection and system evolution of optically integrated PA and OCT, including Michelson interferometer dual-mode imaging system, Fabry-Perot (FP) interferometer dualmode imaging system and Mach-Zehnder interferometer dual-mode imaging system. It is believed that the optically integrated PA and OCT has great potential applications in biomedical imaging.

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Combined photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source

Cited by 70 publications

References 27 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

In vivo spectroscopic photoacoustic tomography imaging of a far red fluorescent protein expressed in the exocrine pancreas of adult zebrafish

All-optically integrated photoacoustic and optical coherence tomography: A review

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