Combined planar and eruptive xanthoma in a patient with type lla hyperlipoproteinemia

Pai, Varadraj V; Shukla, Pankaj; Bhobe, Mayur

doi:10.4103/0378-6323.140323

Cited by 4 publications

(1 citation statement)

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“…Histological examination shows the dermis with collection of pale foamy histiocytes. 35 Reticulohistiocytoma usually presents as a single yellowishred colored nodule on the head and neck of adults. Histological sections show large histiocytes admixed with Touton giant cells and interspersed lymphocytes infiltrating the dermis.…”

Section: Xanthogranulomatous Reactionsmentioning

confidence: 99%

Histopathological Spectrum of Granulomatous Skin Lesions: A Review

George¹

2019

SBV Journal of Basic, Clinical and Applied Health Science

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Background and objectives: Granulomatous dermatoses are the most frequently encountered dermatological disorders in tropical countries with leprosy and tuberculosis as the leading causes. Although granulomatous skin lesions are very prevalent in society today, dermatopathologists often face diagnostic challenges while reporting these lesions due to the similar histopathological features or tissue reaction patterns seen in these lesions with diverse etiologies. The purpose of this study is to review the various causes and patterns of granulomatous skin lesions and a sequential approach to diagnosis of individual lesions accurately. Materials and methods: A comprehensive search of all literature available on granulomatous skin diseases between 2000 and 2018 was conducted, using keywords such as "granulomatous dermatosis, " "cutaneous tuberculosis, " "leprosy, " and "histopathological study" in the databases such as PubMed, ProQuest, and Google Scholar. The articles that satisfied the criteria were included in the final review. Results: The available evidence from the existing systematic literature reviews and articles suggested that the various tissue reaction patterns observed in granulomatous skin lesions are classified as epithelioid, palisaded, suppurative, xanthogranulomatous, foreign body, and other granulomatous patterns. These tissue reaction patterns are caused by infections, foreign bodies, metabolites, chemicals, and malignancies. Conclusion: Granulomatous dermatoses are a heterogeneous group of skin disorders that are frequently encountered in diagnostic dermatopathology. The histomorphology of a granuloma has to be correlated with the clinical history and ancillary techniques including special stains, culture, and molecular methods are necessary to arrive at a definitive diagnosis.

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Section: Xanthogranulomatous Reactionsmentioning

confidence: 99%