Combined Post-Traumatic Total Aniridia and Glaucoma Management

Christodoulou, Eleni; Batsos, Georgios; Parikakis, Efstratios; Papadopoulos, Vlasios; Karagiannis, Dimitrios; Koumoutsos, Panagiotis Petros; Tsilis, Alexandros; Drazinos, S.

doi:10.1159/000511099

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Moreover, there are 300 different iris tones that are available when using this prosthesis. Previous usages reported for the Iris Prosthesis include a combination of trabeculectomy and Iris Prosthesis for traumatic glaucoma [10] , a combination of corneal transplantation and Iris Prosthesis [11] , the use of the Iris Prosthesis with the flange technique performed during a traumatic noniris and nonlens procedure [12] , sewn Iris Prosthesis in cases with lens deviation, iris, and nystagmus [13] , and the use of the Iris Prosthesis in traumatic aniridia cases that occur after radial keratotomy [14] . In our present case, IFIS developed during cataract surgery, which led to an extensive iris defect, although the capsular bag containing the IOL was still present.…”

Section: Discussionmentioning

confidence: 99%

A Case of Foldable Artificial Iris Implantation for Treatment of Postcataract Surgery Aniridia

Watanabe¹,

Kobayakawa²

2023

Case Rep Ophthalmol

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We report an approach for managing acquired aniridia induced by intraoperative floppy iris syndrome (IFIS) during cataract surgery. An 81-year-old man with right blurred vision and photophobia symptoms was treated for extensive iris defects due to cataract surgery aniridia. The retained iris for the patient was observed at the 5–10 o’clock position, with the intraocular lens (IOL) inside the capsular bag. Although the aniridia symptoms were successfully addressed by the implantation of a foldable artificial iris (Iris Prosthesis: Ophtec [formerly Reper], Groningen, the Netherlands), the procedure subsequently caused endothelial damage. In summary, while the utilization of the foldable artificial iris can improve aniridia symptoms, further advances in the insertion technique are required.

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Section: Discussionmentioning

confidence: 99%

A Case of Foldable Artificial Iris Implantation for Treatment of Postcataract Surgery Aniridia

Watanabe¹,

Kobayakawa²

2023

Case Rep Ophthalmol

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“…Therefore, this product has been discontinued in recent years in our medical centre. There are several products that could be applied for intraocular implantation and iris replacement, including the Ophtec 311 non‐foldable iris diaphragm IOL and the currently available HumanOptics and Reper NN devices 27–30 . The last two foldable prosthetic iris products have been proven to be able to successfully address the dual pathology of aniridia, whilst the domestic application is still limited.…”

Section: Discussionmentioning

confidence: 99%

Preclinical biocompatibility and biosafety evaluation of a new foldable brown diaphragm intraocular lens: An in vitro and in vivo study

Zhang

et al. 2023

Clinical Exper Ophthalmology

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Background: A new foldable brown diaphragm intraocular lens (IOL) was preclinically evaluated in vitro and in vivo by comparing its biocompatibility and biosafety with those of a commercially available IOL. Methods:The new foldable iris-diaphragm IOL is composed of hydrophobic acrylic material, with a transparent optical zone and surrounding brown diaphragm. Cellular experiments evaluating lens epithelial cell morphology, adhesion, and migration were conducted to exclude cytotoxic effects. Twelve New Zealand rabbits underwent implantation of a brown diaphragm IOL in one eye, whilst an additional 12 had a commercially available foldable IOL implanted, followed by slit-lamp evaluations of inflammatory reactions and capsular opacification. Corneal endothelial cells density was measured before and after implantation. Aqueous humour samples were obtained weekly for liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis to investigate dye leakage from the brown-diaphragm IOL. Following 12 weeks of observation, haematoxylin and eosin staining of ocular tissue and scanning electron microscopy (SEM) of the IOL surface were performed. Results: Results from in vivo experiments found no statistically significant differences between the two groups in terms of postoperative inflammation and capsular biocompatibility. No significant changes in corneal endothelial cell density were observed in either group before and after surgery. LC-MS/MS analysis showed that the target dye was not detected in aqueous humour Keke Zhang and Shaohua Zhang contributed equally to this work.

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“…54,55 A foldable, highly customizable IOL iris prosthesis, manufactured by Reper Nizhny Novgorod, distributed by Ophtec BV, combines the advantage of simultaneous implantation of an AI and IOL with the small incision required. [56][57][58][59] It includes models designed for sulcus or capsular bag fixation, presenting 5 and 3 haptics, with or without optical effects. 56,57 It is available in 120 different colors and iris patterns.…”

mentioning

confidence: 99%