Combined Preoperative Hypofractionated Radiotherapy With Doxorubicin-Ifosfamide Chemotherapy in Marginally Resectable Soft Tissue Sarcomas: Results of a Phase 2 Clinical Trial

Spałek, Mateusz; Koseła-Paterczyk, Hanna; Borkowska, Aneta; Wągrodzki, Michał; Szumera‐Ciećkiewicz, Anna; Czarnecka, Anna; Castaneda-Wysocka, Patrycja; Kalinowska, Iwona; Poleszczuk, Jan; Dąbrowska-Szewczyk, Edyta; Cieszanowski, Andrzej; Rutkowski, Piotr

doi:10.1016/j.ijrobp.2021.02.019

Cited by 23 publications

(13 citation statements)

References 40 publications

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“…In those assessed for tumor response by RECIST criteria, partial responses were noted in 58% patients [29]. Our other study was dedicated to patients with marginally resectable STS, where the hypofractionated RT was used in combination with chemotherapy used in the interval between RT and surgery; responses in terms of decrease in tumor size were observed [30]. This response was not observed in our group, where the break between RT completion and surgery did not exceed one week.…”

Section: Discussionmentioning

confidence: 60%

Efficacy and Safety of Hypofractionated Preoperative Radiotherapy for Primary Locally Advanced Soft Tissue Sarcomas of Limbs or Trunk Wall

Koseła-Paterczyk

Teterycz

Spałek

et al. 2021

Cancers

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Background: The use of adjuvant radiotherapy (RT) shows a significantly decreased incidence of local recurrence (LR) in soft tissue sarcomas (STS). This study aimed to assess the treatment scheme’s effect in patients with primary STS treated at one institution. Methods: In this phase 2 trial, 311 patients aged ≥18 years with primary, locally advanced STS of the extremity or trunk wall were assigned to multimodal therapy conducted at one institution. The preoperative RT scheme consisted of 5 Gy per fraction for a total dose of 25 Gy. Surgery was performed within 2–4 days from the last day of RT. The primary endpoint was LR-free survival (LRFS). Adverse events of the treatment were assessed. Results: We included 311 patients with primary locally advanced STS. The median tumor size was 11 cm. In total, 258 patients (83%) had high-grade tumors. In 260 patients (83.6%), clear surgical margins (R0) were obtained. Ninety-six patients (30.8%) had at least one type of treatment adverse event. LR was observed in 13.8% patients. The 5-year overall survival was 63%. Conclusion: In this group, with a significant percentage of patients with extensive, high-grade STS, hypofractionated preoperative RT was associated with good local control and tolerance.

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Section: Discussionmentioning

confidence: 60%

Efficacy and Safety of Hypofractionated Preoperative Radiotherapy for Primary Locally Advanced Soft Tissue Sarcomas of Limbs or Trunk Wall

Koseła-Paterczyk

Teterycz

Spałek

et al. 2021

Cancers

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“…Additionally, HFRT is also being increasingly utilized in the definitive setting for multi-disciplinary sarcoma management. 31,32 SBRT is efficacious with high rates of LC in appropriately selected patients. A majority of the evidence is based on SBRT for sarcoma lung metastases.…”

Section: Discussionmentioning

confidence: 99%

Hypofractionated Radiation Therapy for Unresectable or Metastatic Sarcoma Lesions

Boyce-Fappiano

Damron

Farooqi

et al. 2022

Advances in Radiation Oncology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…The guidelines of the American Society for Radiation Oncology (ASTRO) for the first time recommended preoperative over postoperative radiotherapy in patients without significant factors for impaired wound healing after resection [110][111][112][113][114]. Locally advanced MPNST, including radiation-induced MPNST should be treated, if possible, within prospective clinical trials based on combined conventionally fractionated or hypofractionated radiotherapy with systemic treatment or other methods increasing local effectiveness such as hyperthermia [115][116][117]. It is important to consider the higher risk of inducing secondary neoplasms after radiotherapy in the course of NF1, which is particularly important in the case of the group of young patients treated with a radical intention [118].…”

Section: Perioperative Treatmentmentioning

confidence: 99%

Recommendations of the Polish Sarcoma Group on diagnostic-therapeutic procedures and control in patients with type 1 neurofibromatosis (NF1) and the associated malignant neoplasm of peripheral nerve sheaths

Rutkowski

Raciborska²,

Szumera‐Ciećkiewicz

et al. 2022

Nowotwory. Journal of Oncology

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.According to the authors, this elaboration contains the most justified principles of diagnostic-therapeutic procedures. They should, however, be interpreted in relation to the particular clinical situation. The recommendations do not always correspond to the current bases of refunding treatment in force in Poland (which is noted in the text). In the case of doubt, the current possibilities of refunding particular procedures should be ascertained.

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Combined Preoperative Hypofractionated Radiotherapy With Doxorubicin-Ifosfamide Chemotherapy in Marginally Resectable Soft Tissue Sarcomas: Results of a Phase 2 Clinical Trial

Cited by 23 publications

References 40 publications

Efficacy and Safety of Hypofractionated Preoperative Radiotherapy for Primary Locally Advanced Soft Tissue Sarcomas of Limbs or Trunk Wall

Efficacy and Safety of Hypofractionated Preoperative Radiotherapy for Primary Locally Advanced Soft Tissue Sarcomas of Limbs or Trunk Wall

Hypofractionated Radiation Therapy for Unresectable or Metastatic Sarcoma Lesions

Recommendations of the Polish Sarcoma Group on diagnostic-therapeutic procedures and control in patients with type 1 neurofibromatosis (NF1) and the associated malignant neoplasm of peripheral nerve sheaths

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