Combined preoperative plasma fibrinogen and D-Dimer concentration as a prognostic marker of endometrial cancer

Abstract

Endometrial cancer (EC) is one of the most common gynecological malignancies. The aim of this study was to evaluate the combined prognostic value of D-dimer and fibrinogen in EC patients. We evaluated the prognostic value of preoperative plasma fibrinogen and D-Dimer concentration in EC patients using Kaplan-Meier curve analysis and Cox proportional hazards regression model. Kaplan-Meier curve analysis demonstrated that EC patients with higher levels of plasma fibrinogen or D-Dimer had a significantly poorer overall survival (OS) and recurrence-free survival (RFS). Furthermore, combination of fibrinogen and D-Dimer levels significantly improved the efficacy for predicting RFS of EC patient. Patients with higher fibrinogen or D-Dimer levels exhibited a significantly poorer RFS in both the univariate and multivariate analysis. In conclusions, the preoperative plasma fibrinogen and D-Dimer concentrations may serve as potential prognostic factors for EC patients, and combination of fibrinogen and D-Dimer concentration may be a potential marker for predicting RFS of EC patients.