Combined Prevalence of Frailty and Mild Cognitive Impairment in a Population of Elderly Japanese People

Shimada, Hiroyuki; Makizako, Hyuma; Doi, Takehiko; Yoshida, Daisuke; Tsutsumimoto, Kota; Anan, Yuya; Uemura, Kazunori; Ito, Tadashi; Lee, Sang Yoon; Park, Hye-Jin; Suzuki, Takao

doi:10.1016/j.jamda.2013.03.010

Cited by 390 publications

(336 citation statements)

References 49 publications

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“…Participants eligible for this study were selected from older Japanese adults enrolled in a populationbased cohort study: the Obu Study of Health Promotion for the Elderly (OSHPE) [9] that was part of the National Center for Geriatrics and Gerontology -Study of Geriatric Syndromes [10]. Recruitment was conducted via a letter sent to 14,313 individuals aged 65 years or older living in Obu city; 5,104 of these individuals participated in the OSHPE in 2011-2012 at baseline.…”

Section: Methodsmentioning

confidence: 99%

“…Participants were instructed to walk at their normal comfortable pace. The walking time over the 2.4 m middle portion of the course was converted to speed (m/s) [9]. Slow gait was defined as gait speed at normal pace that was 1.0 standard deviations or below age-and sex-appropriate mean values established in this cohort, according to established protocol [1].…”

Section: Mcr Criteriamentioning

confidence: 99%

“…Based on height and weight, body mass index (BMI: kg/m 2 ) were calculated, and obesity was defined as BMI value of 25 kg/m 2 and over as previously described in the Japanese elderly population [26]. Physical inactivity was defined by two questions used in a previous study [9]: (1) "Do you engage in moderate levels of physical exercise or sports aimed at health?" and (2) "Do you engage in low levels of physical exercise aimed at health?".…”

Section: Covariatesmentioning

confidence: 99%

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Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability

Doi

Shimada

Makizako

et al. 2017

JAD

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Abstract.Background: It is important to examine the etiology of motoric cognitive risk syndrome (MCR) and its association with dementia and disability to obtain biological insights and to develop preventive strategies. Objective: This study aimed to examine the association of MCR with incidence of dementia and disability in a Japanese community-dwelling sample of older adults. Methods: Participants were 4,235 older adults (50% women, mean age: 72.0 years). MCR was diagnosed at baseline using established criteria in non-demented seniors with self-reported cognitive complaints and slow gait. Incident cases of dementia were identified from insurance data monthly. Disability was regarded as certification by long-term care insurance. Results: At baseline, 265 participants (6.3%) met criteria for MCR. During follow-up (mean duration: 29 months), there were 138 incident cases of dementia (3.3%) and 207 incident cases of disability (4.9%). Cox-proportional hazards models, adjusted for demographical data, lifestyle, and medical conditions, showed that presence of MCR at baseline was a major risk factor for developing dementia (HR 2.49, 95%CI 1.52-4.10, p < 0.001). MCR also predicted risk for disability (HR 1.69, 95%CI 1.08-2.02, p < 0.001). Conclusions: MCR is helpful in the short-term prediction of risk for dementia and disability in the elderly Japanese population. Identification of seniors with MCR is recommended for early detection and instituting preventive measures for reducing the risk of dementia and disability.

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Section: Methodsmentioning

confidence: 99%

Section: Mcr Criteriamentioning

confidence: 99%

Section: Covariatesmentioning

confidence: 99%

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Motoric Cognitive Risk Syndrome: Association with Incident Dementia and Disability

Doi

Shimada

Makizako

et al. 2017

JAD

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“…Finally, it should be recognized that there is increasing evidence that cognitive decline acts synergistically with physical frailty to accelerate the trajectory to disability (32)(33)(34)(35)(36). This concept of "cognitive frailty" or "the frail brain" is becoming well recognized.…”

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confidence: 99%

Frailty screening comes of age

Morley

2014

The Journal of nutrition, health and aging

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“…There is increasing evidence that psychological and social problems can accelerate the development of disability, hospitalization, nursing home placement and death (14)(15)(16)(17)(18)(19)(20). In some cases the reasons for the synergistic effect are obvious while in others they are more complex and may depend on similar pathophysiological processes accelerating both problems (1,21).…”

mentioning

confidence: 99%