Combined pulsed dye laser and systemic retinoids for the treatment of hypertrophic resistant warts among organ transplant patients

Snast, Igor; Kaftory, Ran; Lapidoth, Moshe; Mazor, Sigal; Hodak, Emmilia; Mimouni, Daniel; Davidovici, Batya B.; Levi, Assi

doi:10.1007/s10103-020-03011-4

Cited by 5 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…43 Systemic retinoids were also mentioned as an optional treatment by a specialized practitioner for specific locations, such as, the hands and feet, for multiple warts, 44 or for immunocompromised patients. 45 Our analysis of the clinical characteristics of the patients, including mean number of lesions (25), mean disease duration prior to initiation of retinoid treatment (13 months), and treatment failure of other modalities pointed to the persistence of cutaneous warts and emphasized the beneficial role of retinoid treatment.…”

Section: Discussionmentioning

confidence: 94%

“…43 Systemic retinoids were also mentioned as an optional treatment by a specialized practitioner for specific locations, such as, the hands and feet, for multiple warts, 44 or for immunocompromised patients. 45 Our analysis of the clinical characteristics of the patients, including mean number of lesions (25) The only side effect associated with topical therapy was ICD, in 32% of the cases. Retinoids can cause inflammation, which contributes to the eradication of the warts, and some authors have postulated that patients in whom inflammation develops have a higher cure rate.…”

Section: Systemic Retinoidsmentioning

confidence: 99%

See 1 more Smart Citation

Topical and systemic retinoids for the treatment of cutaneous viral warts: A systematic review andmeta‐analysis

Oren‐Shabtai

Snast

Noyman

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

Cutaneous viral warts (CVW), caused by human papillomavirus, often have a self‐limited course. However, some patients experience a recalcitrant disease despite treatment. Retinoids are considered the mainstay of therapy in many dermatologic diseases. Data on their use for viral warts are limited. To systematically review the published evidence on the efficacy and safety of retinoids for the treatment of CVW. A systematic review and meta‐analysis of topical or systemic retinoid treatment for CVW was performed in accordance with the PRISMA statement. The primary outcome was clinical response; secondary outcomes were recurrence rate and adverse events. Fourteen publications including 399 patients treated exclusively with retinoids (65% topical, 35% systemic) were evaluated. The complete response rate was 64% (95% CI, 46‐78%; I2=80%) for topical treatment and 61% (95% CI, 44‐76%; I2=69%) for systemic treatment. The most common side effects were irritant contact dermatitis and cheilitis, respectively. Relapse rates were 6% and 17%, respectively. The reviewed studies were considerably heterogenous and most lacked a control group. Both topical and systemic retinoids are effective and safe as monotherapy for CVW. Further studies are required to determine their exact role in this setting.

show abstract

Section: Discussionmentioning

confidence: 94%

“…43 Systemic retinoids were also mentioned as an optional treatment by a specialized practitioner for specific locations, such as, the hands and feet, for multiple warts, 44 or for immunocompromised patients. 45 Our analysis of the clinical characteristics of the patients, including mean number of lesions (25) The only side effect associated with topical therapy was ICD, in 32% of the cases. Retinoids can cause inflammation, which contributes to the eradication of the warts, and some authors have postulated that patients in whom inflammation develops have a higher cure rate.…”

Section: Systemic Retinoidsmentioning

confidence: 99%

Topical and systemic retinoids for the treatment of cutaneous viral warts: A systematic review andmeta‐analysis

Oren‐Shabtai

Snast

Noyman

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…Not only are such warts highly prevalent in organ transplant recipients but also they have low spontaneous regression rates and can be resistant to standard treatment. 16 , 17 , 18 Timely treatment is important as they can negatively impact the quality of life if they persist or recur. 19…”

Section: Discussionmentioning

confidence: 99%

Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort study

Lian

Krishnamoorthy

2021

JAAD International

View full text Add to dashboard Cite

Background Liver transplant recipients are at lifelong risk of immunosuppression-related cutaneous complications, such as malignancy and infection. Objective Our study aims to assess the epidemiology of dermatologic conditions among liver transplant recipients in an academic medical center in Singapore. Methods Medical records of liver transplant recipients on follow-up with gastroenterology and dermatology departments at the Singapore General Hospital between 2006 and 2021 were retrospectively reviewed. A literature review was subsequently performed on the keywords “liver transplant” and “dermatology.” Results A total of 99 liver transplant recipients were identified in this study. Sixty-nine patients (70%) had at least 1 dermatologic condition. Inflammatory skin conditions were the most common (53%), followed by cutaneous infection (36%) and benign cutaneous tumors (30%). Malignant and premalignant lesions were the least common skin conditions reported (10%). Our study results concurred with many other studies reported worldwide, demonstrating a low cutaneous malignancy burden after liver transplantation. Limitations The study included a small population size in a single center and did not have a pre-existing protocol for pretransplant dermatologic surveillance. Conclusion Although the incidence of skin cancer after liver transplant in Singapore is low, the patients will benefit from long-term dermatology surveillance, given the long-term risks of infection and malignant skin conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Verruca vulgaris is a benign epidermal neoplasm caused by a human papillomavirus (HPV) infection of the skin or mucous membrane 1 . There are many methods for local treatment, but there is no radical method yet 1,2 . So far, some studies have shown that using 595‐nm pulsed dye laser has achieved good results in the treatment of verrucae, with a cure rate of up to 71.4% 3 .…”

Section: Introductionmentioning

confidence: 99%

Clinical efficacy evaluation of 595‐nm pulsed dye lasers, microwave tissue coagulation, and liquid nitrogen cryotherapy in the treatment of verruca vulgaris in children

Zhuang

You

Zhang

et al. 2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Objective To evaluate the clinical efficacy and safety of 595‐nm pulsed dye laser in the treatment of verruca vulgaris in children and to compare the efficacy of this method against two other methods, microwave tissue coagulation and liquid nitrogen cryotherapy. Methods A total of 90 children being treated in the dermatology outpatient department of our hospital from 2019 to 2021 were selected and divided into three groups: the treatment group A (n = 30, treated with a 595‐nm pulsed dye laser), treatment group B (n = 30, treated with microwave tissue coagulation), and treatment group C (n = 30, treated with liquid nitrogen cryotherapy). All the patients in the treatment group A, treatment group B, and treatment group C were treated once every two weeks, with a maximum of six treatments. Results The response rate of the treatment group A was 93.3%, which was higher than the 83.3% rate of treatment group B and the 66.7% rate of treatment group C. The average treatment times of the treatment group A (2.45 ± 1.10) were lower than group B (3.51 ± 0.98) and group C (4.63 ± 0.96). The adverse reaction rate in the treatment group A (16.7%) was significantly lower than that in treatment group B (56.7%) and treatment group C (63.3%). The differences were statistically significant (all p < 0.05). Conclusions The 595‐nm pulsed dye laser is safe and seems to be the most effective treatment for verruca vulgaris in children. Further high‐level clinical trial is warranted to verify our results.

show abstract

Combined pulsed dye laser and systemic retinoids for the treatment of hypertrophic resistant warts among organ transplant patients

Cited by 5 publications

References 20 publications

Topical and systemic retinoids for the treatment of cutaneous viral warts: A systematic review andmeta‐analysis

Topical and systemic retinoids for the treatment of cutaneous viral warts: A systematic review andmeta‐analysis

Skin conditions in liver transplant recipients in a Singapore academic medical center: A retrospective cohort study

Clinical efficacy evaluation of 595‐nm pulsed dye lasers, microwave tissue coagulation, and liquid nitrogen cryotherapy in the treatment of verruca vulgaris in children

Contact Info

Product

Resources

About