Combined regimens of cisplatin and metformin in cancer therapy: A systematic review and meta-analysis

Sensitive monitoring of NAD(P)H levels within cancer cells using mitochondria-targeted near-infrared cyanine dyes with optimized electron-withdrawing acceptors

“…Cisplatin, a widely utilized chemotherapy drug for various cancers, including lung cancer, exerts its therapeutic effects by chelating to DNA molecules preventing replication and ultimately resulting in cell death. 76–81 Recent studies have revealed that cisplatin can also influence NAD(P)H concentrations within malignant cells. We treated cells with different doses of cisplatin for 2 hours in a medium devoid of glucose, followed by a subsequent 30-minute incubation with a fluorescent probe in the same medium, Fig.…”

“…[73][74][75] Cisplatin, a widely utilized chemotherapy drug for various cancers, including lung cancer, exerts its therapeutic effects by chelating to DNA molecules preventing replication and ultimately resulting in cell death. [76][77][78][79][80][81] Recent studies have revealed that cisplatin can also influence NAD(P)H concentrations Fig. 13 Fluorescence visuals depicting A549 cells pre-treated with diverse gemcitabine concentrations from 0, 5, 10 to 20 mM in glucose-depleted DMEM medium for 2 hours, followed by a 30 minute incubation with 5 mM of probe A in glucose-depleted DMEM medium.…”

Immunoregulation by resveratrol; implications for normal tissue protection and tumour suppression

“…In spite of remarkable progress in technology regarding cancer therapy and drug design, cancer resistance and severe adverse drug reactions in normal tissue have still remained as tough challenges 10–12 . Novel drugs with low toxicity and higher efficacy have been approved for limited malignancies, and the rest might as well be treated with highly toxic chemotherapy drugs alone or in combination with other modalities such as immunotherapy and radiotherapy 13,14 . It has been reported that radiotherapy combined with novel technologies such as SRS, IMRT and SBRT may cause some side effects for tissues 15 .…”

“…[10][11][12] Novel drugs with low toxicity and higher efficacy have been approved for limited malignancies, and the rest might as well be treated with highly toxic chemotherapy drugs alone or in combination with other modalities such as immunotherapy and radiotherapy. 13,14 It has been reported that radiotherapy combined with novel technologies such as SRS, IMRT and SBRT may cause some side effects for tissues. 15 Furthermore, chemotherapy drugs including both classic and novel drugs can stimulate different reactions depending on the drug type and the exposed organs.…”

Static Magnetic Field reduces cisplatin resistance via increasing apoptosis pathways and genotoxicity in cancer cell lines

“…Cisplatin is a chemotherapy drug that acts through interfering with DNA replication and is mainly administered for the treatment of solid tumors including ovarian, testicular, and lung cancer; similar to many other anticancer agents, it mostly targets cells with a high proliferation index. Given the notorious adverse effects of cisplatin such as nephrotoxicity and neurotoxicity, reducing its administrated dose through combination therapy with other modalities and/or other drugs is highly warranted (3,4). In addition, although initial responsiveness to cisplatin is desirably high, unfortunately, many patients will ultimately face cancer relapse due to cisplatin resistance, which is all the more reason to nd and employ novel combinations of cisplatin and other agents of interest (5).…”