Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: On the impact of parameters related to F1 mating and F2 offspring

Piersma, Aldert H.; Rorije, Emiel; Beekhuijzen, Manon; Cooper, Ralph L.; Dix, David J.; Heinrich-Hirsch, Barbara; Martin, Matthew T.; Mendez, Elizabeth; Müller, André; Paparella, Martin; Ramsingh, Deborah; Reaves, Elissa; Ridgway, Peter; Schenk, Erna; Stachiw, L.; Ulbrich, Beate; Hakkert, Betty C.

doi:10.1016/j.reprotox.2010.11.013

Cited by 42 publications

(26 citation statements)

References 14 publications

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“…The multi-generation study database (Piersma et al, 2011) of 438 substances contained 50 substances that had an EU classification for fertility, development, and/or lactation. These substances are given in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…The multi-generation reproduction toxicity study database was developed as described in detail before (Piersma et al, 2011). Briefly, the USEPA ToxRefDB format (Martin et al, 2009) was used and its content was extended with the database generated by Janer et al (2007) and additional studies.…”

Section: Methodsmentioning

confidence: 99%

“…Therefore it could not have affected the classification decision. This study has been discussed in our previous analysis of multi-generation studies (Piersma et al, 2011) Several other studies showing effects on fertility and development provided the basis for classification as Cat.2, R60-61.…”

Section: Cadmium(ii)chloridementioning

confidence: 96%

“…This effect could also not be reproduced in a second study using identical dose levels (Mullin, 1990). The hydronephrosis in the first study was not dose-related and was considered by JMPR to be within the historical control range (Piersma et al, 2011). Having these studies available, the TC did not classify flusilazole for fertility (TC-Flusilazole, 1999).…”

Section: Flusilazolementioning

confidence: 99%

“…We have concluded that also for classification and labelling in Europe (ECHA, 2011;EU, 2008b) it is highly unlikely that the second generation offspring would contribute significantly (Piersma et al, 2011). This analysis was based on relative parameter sensitivity in terms of lowest observed adverse effect levels (LOAELs) as compared between generations.…”

Section: Introductionmentioning

confidence: 99%

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On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe

Rorije

Müller

Beekhuijzen³

et al. 2011

Regulatory Toxicology and Pharmacology

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Cadmium(ii)chloridementioning

confidence: 96%

Section: Flusilazolementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe

Rorije

Müller

Beekhuijzen³

et al. 2011

Regulatory Toxicology and Pharmacology

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Animal Testing in the Twenty‐First Century: A Review of Traditional Methodologies and Insights into Improving Outcomes by Optimizing Study Designs

Green,

Stump

2023

Patty's Toxicology

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Toxicity testing with animal test subjects is at an interesting crossroads. The many advances in alternative testing methods and computational toxicology models (amongst others) are leading the charge in replacing testing in laboratory animals. However, mandated animal testing for the European Union (EU) REACH regulation, along with its burgeoning cousins around the world has resulted in an enormous increase in animal testing. Hampering the ability to address this increase in testing is the current state of industrial toxicology, where company consolidation, closure of industry‐owned laboratories, and generally tighter budgets have resulted in staff with younger toxicologists that are less prepared for the mass conduct of animal studies. This challenge is exacerbated by current academic training which is focused far more on subcellular methods and “‐omics” than the whole animal models of decades past. Rather than simply rehashing the minutia of guideline study designs, the goal of this chapter is to provide various approaches that toxicologists can use in a method of “holistic toxicity testing” to greatly improve the chances of conducting a high‐quality study by limiting mistakes and omissions and also by conducting testing in such a way that studies conducted today can improve studies conducted in the future.

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Mammalian Methods for Detecting and Assessing Endocrine‐Active Compounds

Marty

2013

Endocrine Disrupters

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Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: On the impact of parameters related to F1 mating and F2 offspring

Cited by 42 publications

References 14 publications

On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe

On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe

Animal Testing in the Twenty‐First Century: A Review of Traditional Methodologies and Insights into Improving Outcomes by Optimizing Study Designs

Mammalian Methods for Detecting and Assessing Endocrine‐Active Compounds

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