Combined royal jelly 10-hydroxydecanoic acid and aspirin has a synergistic effect against memory deficit and neuroinflammation

Abstract

Alzheimer’s disease (AD), the most common form of neurodegenerative dementia among the older population, is associated with acute or chronic inflammation. As a nonsteroidal anti-inflammatory drug, aspirin has recently been...

Royal Jelly: Biological Action and Health Benefits

“…According to papers [58,[138][139][140][141][142][143][144][145][146][147][148][149][150][151][152], RJ has many beneficial effects on cognition and AD pathology, including the improvement of memory, neuroprotection and regulation of neurotrophins, regulation of neurotransmission, regulation of brain energy metabolism, protection against oxidative stress and neuroinflammation, reduction of apoptosis, attenuation of Aβ-induced neurotoxicity, and improvement of hormonal and metabolic abnormalities associated with cognitive impairment (see Figure 3). Many studies have highlighted the important role of neurotropic factors in the etiology and/or development of AD and other age-related diseases, suggesting that the increased synthesis of neuropeptide factors can be a promising avenue in the prevention of these diseases.…”

“…According to papers [ 58 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 ], RJ has many beneficial effects on cognition and AD pathology, including the improvement of memory, neuroprotection and regulation of neurotrophins, regulation of neurotransmission, regulation of brain energy metabolism, protection against oxidative stress and neuroinflammation, reduction of apoptosis, attenuation of Aβ-induced neurotoxicity, and improvement of hormonal and metabolic abnormalities associated with cognitive impairment (see Figure 3 ).…”

10‐hydroxy decanoic acid, trans‐10‐hydroxy‐2‐decanoic acid, and sebacic acid: Source, metabolism, and potential health functionalities and nutraceutical applications

“…Pro‐inflammatory mediator levels were lowered, and the combination treatment synergistically reduced glial cell over‐activation. Additionally, 10‐HDAA reduced the adverse effects of aspirin on dysbiosis of the microbiota and gastrointestinal injury (You et al., 2022).…”

Revealing the Development Patterns of the Mandibular Glands of Apis mellifera carnica Based on Transcriptomics and Morphology

“…Royal jelly contains various biologically active substances and is rich in proteins, sugars, and lipids and contains small quantities of free amino acids, vitamins, and minerals [ 3 ]. The active substances in royal jelly have certain antioxidant [ 4 , 5 ], anti-inflammatory [ 6 , 7 ], antibacterial [ 8 ], antiviral [ 9 ], antitumor [ 10 , 11 ], neuroprotective [ 12 ], and anti-aging [ 13 ] properties. Consequently, royal jelly has been widely recognized by consumers as a natural functional health food.…”