Combined segregation and linkage analysis of HLA markers in familial psoriasis

Guo, Sun Wei; Jenisch, Stefan; Stuart, Philip E.; Lange, Ethan M.; Kukuruga, Debra; Nair, Rajan P.; Henseler, Tilo; Voorhees, John J.; Christophers, Enno; Elder, James T.

doi:10.1038/sj.ejhg.5200810

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Allelic and genotypic variability were assessed and Hardy-Weinberg equilibrium tests were performed using Arlequin v. 3.1 (Excoffier et al, 2005). Specifically, the method of Guo and Thompson (1992) was used to determine if observed heterozygosity at DRB exon 2 was significantly in excess of that expected based on allele frequencies. Pairwise differences among DRB sequences were assessed at both the nucleotide and amino acid levels using DNAsp v. 5.1 (Rozas et al, 2003).…”

Section: Genetic Analysesmentioning

confidence: 99%

MHC variation, multiple simultaneous infections and physiological condition in the subterranean rodent Ctenomys talarum

Cutrera

Zenuto

Lacey

2011

Infection, Genetics and Evolution

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Section: Genetic Analysesmentioning

confidence: 99%

MHC variation, multiple simultaneous infections and physiological condition in the subterranean rodent Ctenomys talarum

Cutrera

Zenuto

Lacey

2011

Infection, Genetics and Evolution

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“…Segregation analysis using pedigreed animal populations is impossible by analytical approaches due to the existence of many (inbreeding) loops and due to the family sizes, which do not allow to sum and integrate out genotypes and polygenic effects from the likelihood or posterior density. This problem has been simplified by the development of Gibbs sampling, a Monte Carlo Markov chain (MCMC) methodology (Guo and Thompson, 1992), and its applications to livestock populations by Sorensen et al (1994), Janss et al (1995), Janss et al (1997) and Ilahi and Kadarmideen (2004).…”

Section: Introductionmentioning

confidence: 99%

Complex Segregation Analysis of Total Milk Yield in Churra Dairy Ewes

Ilahi¹,

Othmane²

2011

Asian Australas. J. Anim. Sci

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The mode of inheritance of total milk yield and its genetic parameters were investigated in Churra dairy sheep through segregation analyses using a Monte Carlo Markov Chains (MCMC) method. Data which consisted of 7,126 lactations belonging to 5,154 ewes were collected between 1999 and 2002 from 15 Spanish Churra dairy flocks. A postulated major gene was assumed to be additive and priors used for variance components were uniform. Based on 50 000 Gibbs samples from ten replicates chains of 100,000 cycles, the estimated marginal posterior means±posterior standard deviations of variance components of milk yield were 23.17±18.42, 65.20±25.05, 120.40±42.12 and 420.83±40.26 for major gene variance ( 2 G σ ), polygenic variance ( 2 u σ ), permanent environmental variance ( 2 pe σ ) and error variance ( 2 e σ ), respectively. The results of this study showed the postulated major locus was not significant, and the 95% highest posterior density regions (HPDs 95% ) of most major gene parameters included 0, and particularly for the major gene variance. The estimated transmission probabilities for the 95% highest posterior density regions (HPDs 95% ) were overlapped. These results indicated that segregation of a major gene was unlikely and that the mode of inheritance of total milk yield in Churra dairy sheep is purely polygenic. Based on 50,000 Gibbs samples from ten replicates chains of 100,000 cycles, the estimated polygenic heritability and repeatability were h 2 = 0.20±0.05 and r = 0.34±0.06, respectively.

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The quest for genetic sequence variants conferring risk of endometriosis

Guo

2020

Human Reproductive Genetics

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Combined segregation and linkage analysis of HLA markers in familial psoriasis

Cited by 3 publications

References 34 publications

MHC variation, multiple simultaneous infections and physiological condition in the subterranean rodent Ctenomys talarum

MHC variation, multiple simultaneous infections and physiological condition in the subterranean rodent Ctenomys talarum

Complex Segregation Analysis of Total Milk Yield in Churra Dairy Ewes

The quest for genetic sequence variants conferring risk of endometriosis

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