Combined Shikonin-Loaded MPEG-PCL Micelles Inhibits Effective Transition of Endothelial-to-Mesenchymal Cells

Li, Guanglin; Shang, Chenxu; Li, Qingqing; Chen, Lifang; Yue, Zejun; Ren, Lingxuan; Yang, Jianjun; Zhang, Jiye; Wang, Weirong

doi:10.2147/ijn.s374895

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…Nowadays, with the development of novel drug delivery systems through the use of liposomes, nanoparticles, cyclodextrin complexes, microemulsions, nanogels, etc., the pharmaceutical innovation of shikonin is in progress with the improvement of shikonin-based drugs. It was observed that methoxy poly (ethylene glycol)-b-poly (ϵ-caprolactone) micelles significantly improved the endothelial-to-mesenchymal transition–inhibiting effect of free shikonin, which makes it suitable for development as a lipophilic drug carrier [ 44 ].…”

Section: Shikonin In Medicine and Pharmacymentioning

confidence: 99%

Natural Plant-Derived Compounds in Food and Cosmetics: A Paradigm of Shikonin and Its Derivatives

et al. 2023

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Shikonin and its derivatives are the natural naphthoquinone compounds produced in the roots of the Boraginaceae family. These red pigments have been used for a long time in coloring silk, as food colorants, and in the Chinese traditional system of medicines The resurgence of public interest in natural and plant-based products has led to this category of compounds being in high demand due to their wide range of biological activities including antioxidant, antitumor, antifungal, anti-inflammatory ones. Different researchers worldwide have reported various applications of shikonin derivatives in the area of pharmacology. Nevertheless, the use of these compounds in the food and cosmetics fields needs to be explored more in order to make them available for commercial utilization in various food industries as a packaging material and to enhance their shelf life without any side effects. Similarly, the antioxidant properties and skin whitening effects of these bioactive molecules may be used successfully in various cosmetic formulations. The present review delves into the updated knowledge on the various properties of shikonin derivatives in relation to food and cosmetics. The pharmacological effects of these bioactive compounds are also highlighted. Based on various studies, it can be concluded that these natural bioactive molecules have potential to be used in different sectors, including functional food, food additives, skin, health care, and to cure various diseases. Further research is required for the sustainable production of these compounds with minimum disturbances to the environment and in order to make them available in the market at an economic price. Simultaneous studies utilizing recent techniques in computational biology, bioinformatics, molecular docking, and artificial intelligence in laboratory and clinical trials would further help in making these potential candidates promising alternative natural bioactive therapeutics with multiple uses.

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Section: Shikonin In Medicine and Pharmacymentioning

confidence: 99%

Natural Plant-Derived Compounds in Food and Cosmetics: A Paradigm of Shikonin and Its Derivatives

et al. 2023

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“…Consequently, the use of micelles in oral formulations is gaining popularity [88]. Li et al [89] investigated the effect of methoxy polyethylene glycol-β-gathering (MPEG-PCL) micelles loaded with Shikonin on inflammatory cytokine-induced endothelial mesenchymal transition (EndMT). The experimental results demonstrated that MPEG-PCL micelles significantly enhanced the cellular absorption of Shikonin.…”

Section: New Dosage Forms Of Shikonin In Diseasesmentioning

confidence: 99%

Pharmacological Effects of Shikonin and Its Potential in Skin Repair: A Review

Song,

Ding,

Hao

et al. 2023

Molecules

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Currently, skin injuries have a serious impact on people’s lives and socio-economic stress. Shikonin, a naphthoquinone compound derived from the root of the traditional Chinese medicine Shikonin, has favorable biological activities such as anti-inflammatory, antibacterial, immunomodulatory, anticancer, and wound-healing-promoting pharmacological activities. It has been reported that Shikonin can be used for repairing skin diseases due to its wide range of pharmacological effects. Moreover, the antimicrobial activity of Shikonin can play a great role in food and can also reduce the number of pathogenic bacteria in food. This paper summarizes the research on the pharmacological effects of Shikonin in recent years, as well as research on the mechanism of action of Shikonin in the treatment of certain skin diseases, to provide certain theoretical references for the clinical application of Shikonin, and also to provides research ideas for the investigation of the mechanism of action of Shikonin in other skin diseases.

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“…On the other hand, the encapsulation of shikonin in nanoparticles coated with saponin and sophorolipid significantly improved its solubility and bioavailability [371]. In another research, shikonin was loaded to MPEG-PCL micelles (methoxy poly (ethylene glycol)-b-poly ( -caprolactone)) which effectively inhibited EMT in endothelial model cells [372].…”

Section: The Bioavailability and Safety Of Compounds Reviewedmentioning

confidence: 99%

Phytochemicals Target Multiple Metabolic Pathways in Cancer

Shuvalov,

Kirdeeva,

Daks

et al. 2023

Antioxidants

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Cancer metabolic reprogramming is a complex process that provides malignant cells with selective advantages to grow and propagate in the hostile environment created by the immune surveillance of the human organism. This process underpins cancer proliferation, invasion, antioxidant defense, and resistance to anticancer immunity and therapeutics. Perhaps not surprisingly, metabolic rewiring is considered to be one of the “Hallmarks of cancer”. Notably, this process often comprises various complementary and overlapping pathways. Today, it is well known that highly selective inhibition of only one of the pathways in a tumor cell often leads to a limited response and, subsequently, to the emergence of resistance. Therefore, to increase the overall effectiveness of antitumor drugs, it is advisable to use multitarget agents that can simultaneously suppress several key processes in the tumor cell. This review is focused on a group of plant-derived natural compounds that simultaneously target different pathways of cancer-associated metabolism, including aerobic glycolysis, respiration, glutaminolysis, one-carbon metabolism, de novo lipogenesis, and β-oxidation of fatty acids. We discuss only those compounds that display inhibitory activity against several metabolic pathways as well as a number of important signaling pathways in cancer. Information about their pharmacokinetics in animals and humans is also presented. Taken together, a number of known plant-derived compounds may target multiple metabolic and signaling pathways in various malignancies, something that bears great potential for the further improvement of antineoplastic therapy.

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Combined Shikonin-Loaded MPEG-PCL Micelles Inhibits Effective Transition of Endothelial-to-Mesenchymal Cells

Cited by 6 publications

References 45 publications

Natural Plant-Derived Compounds in Food and Cosmetics: A Paradigm of Shikonin and Its Derivatives

Natural Plant-Derived Compounds in Food and Cosmetics: A Paradigm of Shikonin and Its Derivatives

Pharmacological Effects of Shikonin and Its Potential in Skin Repair: A Review

Phytochemicals Target Multiple Metabolic Pathways in Cancer

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