Combined sprint and resistance training abrogates age differences in somatotropic hormones

Abstract

The aim of this investigation was to compare serum growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in response to a combined sprint and resistance training (CSRT) program in young and middle-aged men.Thirty-eight healthy, moderately trained men participated in this study. Young and middle-aged men were randomly assigned to, a young training group (YT = 10, 21.4±1.2yrs) ora young control group (YC = 9, 21.6±1.8 yrs), a middle-aged training group (MAT = 10, 40.4±2.1 yrs) or a middle-aged control group (MAC = 9, 40.5±1.8 yrs). Participants performed the Wingate Anaerobic Test (WAnT) before and after a 13-week CSRT program (three sessions per week). Blood samples were collected at rest, after warm-up, immediately post-WAnT, and 10 min post-WAnT. CSRT induced increases in GH at rest and in response to the WAnT in YT and MAT (P<0.05). CSRT-induced increases were observed for IGF-1 and IGFBP-3 at rest in MAT only (P<0.05). Pre-training, GH, IGF-1 and IGFBP-3 were significantly higher at rest and in response to the WAnT in young participants as compared to their middle-aged counterparts (P<0.05). Post-training, YT and MAT had comparable basal GH (P>0.05). In response to the WAnT, amelioration of the age-effect was observed between YT and MAT for IGF-1 and IGF-1/IGFBP-3 ratio following CSRT (P>0.05). These data suggest that CSRT increases the activity of the GH/IGF-1 axis at rest and in response to the WAnT in young and middle-aged men. In addition, CSRT reduces the normal age-related decline of somatotropic hormones in middle-age men.

Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging?

“…Finally, sprint training which is considered the most intense training mode because it includes short bouts of running exercise at high speed (i.e., race over short distances such as 10, 100, 800 m). Benefits of sprinting for the middle aged (40–50 years) including building muscles, burning fat, relieving stress and also improvement of the endocrine system ( 39 – 41 ) have been well demonstrated, however, few and unclear data were reported in elderly subjects with regard to all the body's system and especially to the immunity response, which was more apparent in other type of training.…”

Differing Effects of Younger and Older Human Plasma on C2C12 Myocytes in Vitro

“…Whilst not measured here, it should be acknowledged that a large number of endocrine factors are suggested to change with human ageing. These include classic anabolic factors such as growth hormone, insulin and IGF (Ratkevicius et al, 2011 ; Sellami et al, 2017 ), as well as the likely catabolic, low level of pro-inflammatory cytokines such as tumour necrosis factor alpha and interleukin 1 beta (Ferrucci et al, 2005 ; Alvarez-Rodríguez et al, 2012 ). Further, more recently identified factors such as Klotho act in an endocrine manner in mice and appear to regulate lifespan (Kurosu et al, 2005 ).…”

“…Indeed, ageing is associated with changes in circulating factors that are known to moderate muscle mass, including the growth factors testosterone, growth hormone, and IGF (Ratkevicius et al, 2011 ; Sellami et al, 2017 ) and pro-inflammatory cytokines (Ferrucci et al, 2005 ; Alvarez-Rodríguez et al, 2012 ). The transforming growth factor beta (TGF-β) family of signalling peptides is relatively less studied.…”

Validity and Reliability of the 30-s Continuous Jump for Anaerobic Power and Capacity Assessment in Combat Sport

“…The CJ30s was preceded by a general warm-up (<50% VO 2max ) composed of jogging, walking, and stretching for about 15 min ( Tomaras and MacIntosh, 2011 ; Sellami et al, 2017a , b ) and specific warm-up composed of five joint mobility exercises (one set of 10-s) with emphasis on the lower limbs and 6′ walking on treadmill (0% at 4.5 km/h); 2′ of recovery and two jumps with 1-min in-between to avoid any fatigue effects ( Chamari et al, 2001 ). The test started (∼3′) when the oxygen consumption and heart rate reached about the baseline value (compared to the rest before the warm-up) ( Chamari et al, 2001 ).…”