2008
DOI: 10.1001/archotol.134.6.630
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Combined Stimulation of Nasal Polyp Fibroblasts With Poly IC, Interleukin 4, and Tumor Necrosis Factor α Potently Induces Production of Thymus- and Activation-Regulated Chemokine

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Cited by 3 publications
(2 citation statements)
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“…The same author found that the stimulation of NPDF with poly IC, poly IC and TNF-α, poly IC and IL-4, or IL-4 and TNF-α induced a significant increase in the expression of TARC. Furthermore, the simultaneous exposure of cells to poly IC, IL-4, and TNF-α induced an even higher increase in the expression of CCL17 (TARC) [96,97]. In view of these findings, IL-4 seems fundamental in the induction of CCL17 (TARC) expression by NPDF and in the regulation of T2 cell chemotaxis.…”
Section: Chemokine C-c Motif Ligand 2 (Ccl2)mentioning
confidence: 86%
“…The same author found that the stimulation of NPDF with poly IC, poly IC and TNF-α, poly IC and IL-4, or IL-4 and TNF-α induced a significant increase in the expression of TARC. Furthermore, the simultaneous exposure of cells to poly IC, IL-4, and TNF-α induced an even higher increase in the expression of CCL17 (TARC) [96,97]. In view of these findings, IL-4 seems fundamental in the induction of CCL17 (TARC) expression by NPDF and in the regulation of T2 cell chemotaxis.…”
Section: Chemokine C-c Motif Ligand 2 (Ccl2)mentioning
confidence: 86%
“…Fibroblasts are key players in the epithelial growth and repair process and may serve to promote the inflammatory state in CRS. Fibroblast cultures derived from polyps express the lymphocyte chemokine thymus and activation-regulated chemokine (CCL-17) when stimulated with agonists for TLR2 to TLR5, IL-4, or tumor necrosis factor-α [51•,52,53]. Interestingly, recent evidence suggests that TLRs on epithelial cells may activate signaling cascades using the epidermal growth factor receptor, supporting the tight association between innate immunity and injury repair [5456].…”
Section: Crs and Epithelial Innate Immunitymentioning
confidence: 99%