Combined study of docking and molecular dynamics against DNV-3 SN1 protein by bixinoids

Fonseca, Aluísio Marques da; Soares, Neidelênio Baltazar; Meirú, Maria Imaculada Lourenço; Colares, Regilany Paulo; Neto, Moises Maia; Sobrinho, Antonio Carlos Nogueira; Santos, Hélcio Silva dos; Marinho, Emmanuel Silva

doi:10.1080/07391102.2022.2070282

Cited by 2 publications

(6 citation statements)

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“…Bixa orellana dye obtained as a solid is a red powder with a melting point of 190 °C and is rarely soluble in water as shown in Table . The poor solubility in water of the pigment is due to the small proportion of norbixin (less than 20%), the water-soluble constituent in comparison with bixin (about 80%) which is fat soluble . The available structures for the two compounds revealed that norbixin has two hydroxyl end-groups, while bixin has just one of its hydroxyls methylated.…”

Section: Resultsmentioning

confidence: 99%

“…Norbixin (Figure ) is a demethylated derivative of bixin. Although it is a naturally occurring compound, it is almost always referred to as a saponification product of bixin . Norbixin is a chemically unstable compound when isolated and is converted via isomerization into bixin trans-(β-bixin), the cis-trans isomer of bixin.…”

Section: Introductionmentioning

confidence: 99%

“…The annatto seeds contain about 5% pigment, which consists of 70–80% of bixin. The bixin is soluble in fats but insoluble in water . When exposed to alkalis, the methylester is hydrolyzed and produces norbixin dicarboxylic acid, a water-soluble derivative.…”

Section: Introductionmentioning

confidence: 99%

“…The bixin is soluble in fats but insoluble in water. 11 When exposed to alkalis, the methylester is hydrolyzed and produces norbixin dicarboxylic acid, a water-soluble derivative. Norbixin ( Figure 2 ) is a demethylated derivative of bixin.…”

Section: Introductionmentioning

confidence: 99%

“…Although it is a naturally occurring compound, it is almost always referred to as a saponification product of bixin. 11 Norbixin is a chemically unstable compound when isolated and is converted via isomerization into bixin trans-(β-bixin), the cis-trans isomer of bixin. Carotenoids bixin and norbixin have two stereo configurations, i.e., cis and trans.…”

Section: Introductionmentioning

confidence: 99%

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Ethanol-Based Extraction of Annatto (Bixa Orellana L.) and Characterization of the Bixin and Norbixin

Aluko

2024

ACS Omega

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Bixa orellana dye was extracted from the seeds by the method of Soxhlet extraction using ethanol where a percentage yield of 31.4 was obtained. Recrystallization of the dye was performed using chloroform and ethanol to increase the degree of purity. Thin layer chromatography was used to separate the dye into Bixin and Norbixin with R f values of 0.56 and 0.42, respectively. The extracted dye was pH sensitive, insoluble in water but soluble in some organic solvents like ethanol and acetic acid. Characterization by UV−vis spectroscopy showed maximum absorption for Bixin and Norbixin at 457 and 453 nm, respectively. Fourier transform infrared spectra of Bixin and Norbixin showed bands confirming similar functional groups for both Bixin and Norbixin except for −CO− stretching and methylene vibration which was absent in Norbixin. With the yield, purity level, and other properties of the extracted dye, the comparative advantages of ethanol-based Soxhlet extraction of the dye were well established.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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