Combined subconjunctival pegylated (Peg) interferon alpha 2a injection and amniotic membrane graft for management of extensive conjunctival papillomatous neoplasia- A case report

Abstract

To report the management of a case presented with recurrent extensive conjunctival papillomatous neoplasia. Case Report: A 2 year old girl presented with left recurrent extensive conjunctival squamous papilloma being treated surgically thrice along with adjunctive cryotherapy and topical Mitomycin C (MMC). We managed the case with surgical excision again with adjunctive subconjunctival or sublesional pegylated (peg) interferon alpha 2a injection along with the whole surface amniotic membrane graft. The patient had upper canalicular papillomatous lesion which was also managed by surgical excision and subcanalicular peg-interferon alpha 2a injection. There was no recurrence in subsequent 3 months follow up. Conclusion: Subconjunctival pegylated interferon alpha 2a injection and amniotic membrane graft may be a novel combined modality to manage extensive conjunctival squamous papillomatous neoplasia that may yield successful outcome.