Combined surgery and chemotherapy in the treatment of malignant tumors

Denk, W; Karrer, K

doi:10.1002/1097-0142(196111/12)14:6<1197::aid-cncr2820140609>3.0.co;2-1

Cited by 22 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Especially in Europe surgery has never been entirely abandoned as primary treatment for SCLC (12)(13)(14). Moreover, a sub-group of patients with peripherally located SCLC, presented as 'coin lesions', showed postsurgical survival comparable to coin lesions of primary bronchogenic adeno-and squamous cell carcinoma (15).…”

Section: Scandinavian University Press 1995 Issn 0284-186xmentioning

confidence: 99%

Surgery For Cure Followed By Chemotherapy In Small Cell Carcinoma Of The Lung: For The Isc-Lung Cancer Study Group

Karrer

Ulsperger

1995

Acta Oncologica

View full text Add to dashboard Cite

Section: Scandinavian University Press 1995 Issn 0284-186xmentioning

confidence: 99%

Surgery For Cure Followed By Chemotherapy In Small Cell Carcinoma Of The Lung: For The Isc-Lung Cancer Study Group

Karrer

Ulsperger

1995

Acta Oncologica

View full text Add to dashboard Cite

“…At the time, some investigators had reported favourably on long-term adjuvant chemotherapy with cyclophosphamide (Denk & Karrer, 1961;Poulsen, 1962Poulsen, , 1963 and on the activity of busulphan against inoperable bronchial carcinoma (Sullivan, 1958). However, the relative sensitivity of small cell compared with non-small cell carcinomas to chemotherapy (Green et al, 1969;Higgins, 1972;Host, 1973;Selawry, 1974), and the superiority of pulsed chemotherapy with an interval between each dose (Bergsagel, 1971;Karrer, 1972) and of treatment with combinations of drugs (Carbone et al, 1970;Alberto, 1973;Maurer & Tulloh, 1974;Bunn et al, 1977) (Kron et al, 1982;Spiro & Goldstraw, 1984).…”

Section: Discussionmentioning

confidence: 99%

Fifteen-year follow-up of all patients in a study of post-operative chemotherapy for bronchial carcinoma

Girling¹,

Stott²,

Stephens³

et al. 1985

Br J Cancer

View full text Add to dashboard Cite

Plan and conduct of the studyThe plan and conduct of the study were described in detail previously (Medical Research Council, 1971). In summary, after resection of all intrathoracic bronchial tumour, the patients were allocated at random to receive tablets of busulphan (B series), cyclophosphamide (C series), or indistinguishable placebos (P series) daily for 2 years. For the first 10 days following operation, all patients received 8 tablets in a single daily dose (B series 4 mg, C series 200 mg). Thereafter they received 6 tablets daily (B series 3 mg, C series 150 mg). However, after about the first year of intake to the study, these maintenance dosages were reduced from 6 to 3 tablets (B series 1.5 mg, C series 75 mg), because of an unexpectedly high incidence of toxicity. The 3 series were very similar with respect to sex, age, type of operation, bronchial site of tumour, histological type of tumour, and whether or not the resected lymphnodes were histologically involved.Each patient was reported on monthly during the first 3 years, 3-monthly up to 5 years, and annually thereafter. Total leucocyte and platelet counts and haemoglobin concentrations were measured every month during the first 2 years, and thereafter when requested by the clinician. The maintenance dose of tablets was controlled by the clinician from the results of the blood investigations and the dose was reduced if haematological toxicity was suspected.The study was conducted double-blind. The certified cause of death was obtained from the local centre and was verified from the death entries at the OPCS for all but 2 of the deaths.It is important to note that as the study was planned in 1964, some of the peri-operative staging procedures which would now be considered desirable were not required as a routine and when done were not necessarily reported. In particular, the following were not specifically requested as part of the protocol: recording recent weight loss, mediastinoscopy, isotope scans, liver function tests, marrow aspiration or biopsy, routine dissection of the mediastinal nodes at operation, or reporting the size of the tumour in the resected specimen.X3

show abstract

“…Denk et al (1961) report a series of 282 cases of carcinoma of the bronchus which have been treated chemotherapeutically for two years after radical operation, and claim that at 18 months the survival rate was 81 % compared with 42% without the drug. This form of treatment has not been used in this series.…”

Section: Discussionmentioning

confidence: 99%