Combined surgical treatment of lung cancer and heart diseases

Kovacicova, K; Omran, Nedal; Mand'ák, J

doi:10.4149/bll_2014_150

Cited by 8 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings of this study are supported by previous studies that have shown that the one-stage approach did not increase the surgical trauma and affect postoperative recovery [ 26 ]. The cumulative survival rate in this study was 47.9% at five years.…”

Section: Discussionsupporting

confidence: 89%

Combined Coronary Artery Bypass Graft (CABG) Surgery and Lung Resection for Lung Cancer in Patients More than 50 Years-of-Age

Liu

Chen

et al. 2018

Med Sci Monit

View full text Add to dashboard Cite

BackgroundThe co-existence of coronary heart disease (CHD) and lung cancer is increasing in an increasingly aging population. The aim of this study was to evaluate patient outcome from combined off-pump coronary artery bypass graft (CABG) surgery and lung resection in patients more than 50 years-of-age.Material/MethodsA retrospective clinical study of 23 patients with a mean age of 70.2±8.4 years (range, 51–86 years) included 18 men and five women with CHD and lung cancer who underwent a single operation with combined off-pump CABG surgery and lung resection, for non-small cell lung cancer (NSCLC) (n=22) and small cell lung cancer (n=1). Surgical approaches included: median sternotomy in six patients; left lateral thoracotomy in nine patients; a median sternotomy in three patients; median sternotomy combined with thoracoscopic lobectomy in five patients.ResultsIn the retrospective study of 23 patients, there were no deaths and no new cases of myocardial infarction (MI) in the immediate perioperative period. During the follow-up period, six patients died from lung cancer metastasis or recurrence; one patient died of acute renal failure; and one patient died from the effects of chemotherapy. The remaining 15 patients underwent postoperative follow-up for between 3–79 months with no deaths and no new cases of MI.ConclusionsFor patients who are more than 50 years-of-age and who have CHD and lung cancer, a single combined operation that includes off-pump CABG and lung resection can be safe and effective.

show abstract

Section: Discussionsupporting

confidence: 89%

Combined Coronary Artery Bypass Graft (CABG) Surgery and Lung Resection for Lung Cancer in Patients More than 50 Years-of-Age

Liu

Chen

et al. 2018

Med Sci Monit

View full text Add to dashboard Cite

show abstract

“…All the complications were treated and all the patients were discharged from the hospital except the one died of pneumonia at 1 month after surgery. The simultaneous surgeries did not increase the surgical trauma and affect postoperative recovery [26]. The cumulative 5-year survival rate is 52.9% in our series.…”

Section: Discussionmentioning

confidence: 62%

“…Simultaneous surgery has already been carried out in the 1980s for combined treatment of pulmonary neoplasia and cardiac surgical disorders. In one stage operation, CABG is performed first, considering cardiac surgery is an aseptic surgery, and cardiac revascularization is carried out first to avoid perioperative myocardial ischemia [25, 26]. Compared to a two-stage operation, a one-stage operation also has advantages including a single induction of general anesthesia, shorter overall hospital stay, and reduced cost of treatment [27].…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of mortality and morbidity varied with each technique. Patients who underwent off-pump bypass had a 0% mortality, and 0-48% morbidity, in comparison to 0% to 20.8% and 0% to 67% among conventional bypass treated patients, respectively [26]. The off-pump bypass may avoid the detrimental effect of extracorporal circulation, which would affect tumor growth and dissemination [29, 30].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Feasibility and efficacy of simultaneous off-pump coronary artery bypass grafting and esophagectomy in elderly patients

Liu

Wang

et al. 2017

Oncotarget

View full text Add to dashboard Cite

IntroductionTo analyze the outcomes of off-pump coronary artery bypass grafting (OPCABG) and esophagectomy simultaneously for patients with coronary artery disease (CAD) and coexisting esophageal cancer.MethodsTwenty-two patients with CAD and coexisting esophageal cancer underwent combined surgical interventions were subjected to the study. OPCABG was performed first, followed by esophagectomy. All the corresponding data including clinicopathological characteristics and postoperative outcomes were all investigated.ResultsAll the combined procedures were performed successfully. The average number of grafts was 2.36. Tumors were located at the middle third of the esophagus in 5 patients, at the lower third of the esophagus in 8 patients, at the esophageal gastric junction (EGJ) in 9 patients, respectively. The operations were carried out through a left lateral thoracotomy approach in 21 patients while a median sternotomy and left lateral thoracotomy approach was used in 1 patient for his condition rapidly worsened. Postoperatively, pneumonia occurred in 4 patients (18.2%). During the follow-up, three patients died of cancer metastasis /recurrence (6, 18, 37 months) and one died of pneumonia (1 month). The cumulative 5 years survival rate is 52.9%.ConclusionsThe combined procedure of OPCABG and esophagectomy is a safe and effective treatment option for patients with severe CAD and esophageal cancer.

show abstract

“…A total of 29 eligible studies were nally included in the present metaanalysis (3,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). These studies were carried out in the following geographical regions: ve in USA (8,19,20,32,35), four in China (3,11,25,26), four in Netherlands (7,13,30,33), three in Italy (14,18,29), two in Czech Republic (12,24), two in Japan (10,16), two in Turkey (9, 15), one in Australia (34), one in Belgium (6), one in C...…”

Section: Study Searches and Characteristicsmentioning

confidence: 99%

Perioperative outcomes of combined heart surgery and lung tumor resection: A systematic review and meta-analysis

Cheng

Jiang

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: The coexistence of concomitant lesions of the heart and lungs needed surgical intervention is increasing. Simultaneous cardiac surgery with pulmonary resection can solve the lesions at the same time, thus avoiding the second operation. However, concern exists regarding the potentially increased mortality and complication rate of simultaneous surgery and the adequacy of lung exposure during heart surgery. Therefore, we performed a meta-analysis to evaluate the perioperative mortality and complication rate of combined heart surgery and lung tumor resection.Methods: A comprehensive literature search was performed in July 2020. PubMed, Embase and Web of Science databases were searched to collect studies reported the perioperative outcomes of combined heart surgery and lung tumor resection. Two reviewers independently screened literatures, extracted data and assessed the risk of bias of included studies. Pooled proportion and its 95% confidence intervals (95% CI) was performed by R version 3.6.1 using the meta package.Results: A total of 536 patients from 29 studies were included in this analysis. Overall, the results of this meta-analysis showed that the pooled proportion of operative mortality was 0.01 (95% CI: 0.00, 0.03) and the pooled proportion of postoperative complications was 0.40 (95% CI: 0.24, 0.57) for patients underwent combined cardiothoracic surgery. Subgroup analysis by lung pathology revealed that, for lung cancer patients, the pooled proportion of anatomical lung resection was 0.99 (95% CI: 0.95, 1.00), and the pooled proportion of systematic lymph node dissection or sampling was 1.00 (95% CI: 1.00, 1.00). Subgroup analysis by heart surgery procedures found that the pooled proportion of postoperative complications of coronary artery bypass grafting (CABG) patients using off-pump method was 0.17 (95% CI: 0.01, 0.43), while the pooled proportion of on-pump method was 0.61 (95% CI: 0.38, 0.82).Conclusion: This study presented that combined heart surgery and lung tumor resection had a low mortality rate and an acceptable complication rate. Subgroup analysis revealed most lung cancer patients underwent uncompromised anatomical resection and mediastinal lymph node sampling or dissection during combined cardiothoracic surgery, and showed off-pump CABG could potentially reduce the complication rate compared with on-pump CABG. While further researches are still needed.

show abstract

Combined surgical treatment of lung cancer and heart diseases

Cited by 8 publications

References 23 publications

Combined Coronary Artery Bypass Graft (CABG) Surgery and Lung Resection for Lung Cancer in Patients More than 50 Years-of-Age

Combined Coronary Artery Bypass Graft (CABG) Surgery and Lung Resection for Lung Cancer in Patients More than 50 Years-of-Age

Feasibility and efficacy of simultaneous off-pump coronary artery bypass grafting and esophagectomy in elderly patients

Perioperative outcomes of combined heart surgery and lung tumor resection: A systematic review and meta-analysis

Contact Info

Product

Resources

About