Combined Systemic and Intratumoral Administration of Human Papillomavirus Vaccine to Treat Multiple Cutaneous Basaloid Squamous Cell Carcinomas

Nichols, Anna; Gonzalez, Adrianna; Clark, Emily; Khan, Wasif N.; Rosen, Alyx C.; Guzman, Wellington; Rabinovitz, Harold; Badiavas, Evangelos V.; Kirsner, Robert S.; Ioannides, Tim

doi:10.1001/jamadermatol.2018.1748

Cited by 63 publications

(71 citation statements)

References 13 publications

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“…[62] The human papillomavirus vaccine (HPV) has also been shown to prevent and treat keratinocyte carcinomas. [63,64] One study looked ing. [65] Risk stratification can help to prevent screening of low-risk populations which may contribute to increased treatment costs with limited mortality benefit through the overdiagnosis of melanoma and skin cancer, as seen with other cancer types such as breast and prostate cancers.…”

Section: Role Of Primary Pre Venti On In Decre a S Ing The In Cidenmentioning

confidence: 99%

Biomarkers in melanoma and non‐melanoma skin cancer prevention and risk stratification

Trager

Geskin

Liu

2020

Experimental Dermatology

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One in five Americans is affected by skin cancer, making it the most common cancer in the United States. Excluding non-melanoma skin cancer (NMSC), melanoma is the fifth most common cancer, and it is projected that over 100 000 new cases of melanoma will be diagnosed in the United States by the end of 2020. Although melanoma accounts for only 1% of all skin cancers, it causes a majority of deaths and it is expected that almost 7000 people will die from melanoma by the end of the year. [1] Each year, over 5.4 million cases of NMSC are treated in the United States in over 3.3 million people. [2] Despite continuous efforts to promote public awareness about sunburn and skin cancer risk, sunburn remains highly prevalent among American adult populations (Figure 1). Surveys from the Centers for Disease Control (CDC) show that sunburn prevalence remains high, with 50.1% of all American adults and 65.6% of whites aged 18-29 years reporting at least one sunburn every year. [3] Sunburn usually diminishes several days after exposure; however, repeated sunburn causes cumulative genetic and epigenetic damage in skin cells. Although sunburn is a well-established risk factor in skin carcinogenesis, there are often decades-long delays between sunburn events and visible skin tumor lesions (Figure 2). Sunburn-induced molecular changes can persist for years to decades in sun-exposed pre-malignant skin, which can lead to malignant transformation over time. While conventional skin cancer screening methods including dermoscopy are useful in tumor detection, they often fail to detect tumors at early stages due to their inability to detect such cancer-causing molecular alterations prior to visible tumor formation. [4-6] Currently, measurement of skin sun damage relies on the use of minimal erythema dose (MED), which describes the amount of ultraviolent radiation (UVR) that produces visible skin

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Section: Role Of Primary Pre Venti On In Decre a S Ing The In Cidenmentioning

confidence: 99%

Biomarkers in melanoma and non‐melanoma skin cancer prevention and risk stratification

Trager

Geskin

Liu

2020

Experimental Dermatology

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“…8 Another recent study reported the complete regression of multiple cutaneous basaloid squamous cell carcinomas in a 90-year-old female following both intratumoral and intramuscular injections of the 9-valent HPV vaccine (Gardasil-9; Merck & Co Inc). 9 The mechanism of action is unclear; either due to an activation of innate immunity in response to the aluminum adjuvant in the vaccine, 10 or more likely, to the contributing viral component. 11 Most keratoacanthomas are self-resolving benign epidermal lesions, but are generally considered a well-differentiated variant of SCC.…”

Section: Discussionmentioning

confidence: 99%

The Successful Treatment of Multiple Cutaneous Malignancies with HPV Vaccination: Case Report

Geizhals

Lebwohl

2020

J of Skin

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An elderly, immunocompetent patient presented multiple invasive squamous cell carcinomas of the keratoacanthoma subtype superimposed on a psoriatic plaque. After failing initial treatment with oral acitretin, alternative therapies were considered. Due to the patient’s advanced age, location of the tumors and extensive tumor burden, invasive therapy was deemed impractical. After careful consideration, the more novel approach of injecting the 9-valent HPV vaccine was performed. Ten months after the first dose, the patient’s skin displayed neither clinical or histologic evidence of any residual cancer. We believe that this is the second reported case of the 9-valent HPV vaccine successfully treating non-melanoma cutaneous malignancies.

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“…Given increased susceptibility to HPV16- and HPV18-associated SCCs of the cervix, vulva, vagina, penis, anus, oral cavity, and pharynx in post–allo-SCT patients, some have proposed off-label use of the quadrivalent HPV vaccine 6 . HPV vaccination may also have a role as an intratumoral chemotherapeutic agent 7 . Our patient did receive the full schedule of the quadrivalent HPV vaccine after transplant but nonetheless went on to have multiple HPV-associated SCCs, highlighting the importance of further investigation of the proper timing of the administration of these vaccinations and effectiveness in this patient population.…”

Section: Discussionmentioning

confidence: 99%

The management of numerous carcinomatous sequelae of human papilloma virus in an allogeneic stem cell transplant patient with chronic graft versus host disease

et al. 2019

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Combined Systemic and Intratumoral Administration of Human Papillomavirus Vaccine to Treat Multiple Cutaneous Basaloid Squamous Cell Carcinomas

Cited by 63 publications

References 13 publications

Biomarkers in melanoma and non‐melanoma skin cancer prevention and risk stratification

Biomarkers in melanoma and non‐melanoma skin cancer prevention and risk stratification

The Successful Treatment of Multiple Cutaneous Malignancies with HPV Vaccination: Case Report

The management of numerous carcinomatous sequelae of human papilloma virus in an allogeneic stem cell transplant patient with chronic graft versus host disease

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