Combined therapy associating systemic platinum-based chemotherapy and local radiotherapy into the treatment of primary intraocular lymphoma

Tempescul, Adrian; Pradier, Olivier; Marianowski-Cochard, Catherine; Ianotto, Jean‐Christophe; Berthou, Christian

doi:10.1007/s00277-010-1139-2

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…46 Treatment of humans with primary intraocular lymphoma has not been standardized because of the low number of reported cases. However, systemic, [47][48][49] intrathecal, 50,51 and intraocular [52][53][54][55][56] administration of chemotherapeutic drugs with or without adjunctive orbital radiation therapy [57][58][59] have been used. Cytosine arabinoside and methotrexate are the most commonly used chemotherapeutic agents because they penetrate the blood-ocular barrier.…”

Section: Discussionmentioning

confidence: 99%

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Wiggans¹,

Skorupski²,

Reilly³

et al. 2014

javma

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Objective—To determine prevalence, reason for evaluation, treatment, and outcome for dogs and cats with presumed solitary ocular lymphoma (PSOL). Design—Retrospective case series. Animals—7 dogs and 2 cats with PSOL. Procedures—Medical records were reviewed. Progression-free survival time (PFST) and overall survival time (OST) were determined. Results—Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively. Animals with intraocular lymphoma represented 0.19% of all patients with uveitis; animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis. Tumors included B-cell (2 intraocular and 1 conjunctival), non–B-cell, non–T-cell (1 intraocular), and T-cell (3 conjunctival) neoplasms; immunophenotype of 2 uveal lymphomas was not determined. Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival). All dogs with intraocular lymphoma developed neurologic signs. Lymph node metastasis was detected in 2 patients with conjunctival lymphoma. Median PFST and OST were 178 days for all animals with PSOL, dogs with PSOL, and animals with intraocular lymphoma. Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively. Conclusions and Clinical Relevance—Results indicated PSOL was uncommon, but should be considered a differential diagnosis for animals with uveitis or conjunctivitis. Performance of MRI and cytologic analysis of CSF and regional lymph node aspirate samples may be beneficial for such patients. Prognosis seemed to be better for animals with conjunctival lymphoma than it was for those with intraocular lymphoma.

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Section: Discussionmentioning

confidence: 99%

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Wiggans¹,

Skorupski²,

Reilly³

et al. 2014

javma

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“…These drugs have been investigated and showed effectiveness [23-26]. A combination of chemotherapy and radiation therapy is also applicable [27]. …”

Section: Discussionmentioning

confidence: 99%

Anaplastic Large Cell Lymphoma Involving Anterior Segment of the Eye

Park

Hwang

Kim

et al. 2014

Korean J Ophthalmol

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A 36-year-old woman was diagnosed with anaplastic large cell lymphoma (ALCL) by excisional biopsy of a left frontal skin lesion. During the first cycle of chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone), the patient complained of right ocular pain and inflammation. Cytologic examination using aqueous humor revealed atypical lymphocytes, suggesting intraocular ALCL involvement. Acute angle closure developed in the anterior chamber due to rapid progression of ALCL, causing pupillary block. Laser and surgical interventions were attempted but failed to relieve the pupillary block. Finally, radiation therapy resolved the pupillary block to restore the anterior chamber and normalize intraocular pressure. This is the first case in the English literature of ALCL involving the iris to cause acute secondary angle closure.

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“…14,163,190 High dose methotrexate is the most active drug, producing a response rate of up to 72% when used alone and up to 94e100% in combinations. 16,175,193 Osmotic blood brain barrier disruption to increase brain penetration of chemotherapy is associated with non-sight threatening maculopathy.…”

Section: Chemotherapymentioning

confidence: 99%

Primary Intraocular Lymphoma

Seshadri¹,

Jena²,

Tripathy³

2017

Ophthalmology: Current and Future Developments

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Combined therapy associating systemic platinum-based chemotherapy and local radiotherapy into the treatment of primary intraocular lymphoma

Abstract: Ianotto, Christian Berthou. Combined therapy associating systemic platinum-based chemotherapy and local radiotherapy into the treatment of primary intraocular lymphoma.

Cited by 9 publications

References 10 publications

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Anaplastic Large Cell Lymphoma Involving Anterior Segment of the Eye

Primary Intraocular Lymphoma

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