Combined toxicity and toxicity persistence of antidepressants citalopram and mirtazapine to zooplankton Daphnia magna

Ma, Yunfeng; Dong, Xiaohong; Li, Chenyang; Wei, Shu; Guo, Ruixin; Li, Yang; Chen, Jianqiu; Liu, Yanhua

doi:10.1007/s11356-022-20203-3

Cited by 16 publications

(2 citation statements)

References 39 publications

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“…Increased heart rates in the crustaceans species shore crab Carcinus maenas and in zebrafish embryos following fluoxetine or serotonin exposures and in D. magna individuals exposed to the SSRI citalopram have been reported elsewhere (Blahova et al, 2021;Ma et al, 2022;Robert et al, 2019), which agrees with the reported effects in second brood neonates. Tributyltin decreased heart rate of zebrafish embryos and the clam Ruditapes decussatus (Berto-Júnior et al, 2018;Hanana et al, 2014), which supports the results obtained in third brood neonates.…”

Section: Discussionsupporting

confidence: 85%

Developmental Defects in Cognition, Metabolic and Cardiac Function Following Maternal Exposures to Low Environmental Levels of Selective Serotonin Re-Uptake Inhibitors and Tributyltin in Daphnia Magna

Moro,

Raldúa,

Barata

2023

Preprint

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Section: Discussionsupporting

confidence: 85%

Developmental Defects in Cognition, Metabolic and Cardiac Function Following Maternal Exposures to Low Environmental Levels of Selective Serotonin Re-Uptake Inhibitors and Tributyltin in Daphnia Magna

Moro,

Raldúa,

Barata

2023

Preprint

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“…Furthermore, it should be considered that these compounds, together with their TPs, are often only removed in small percentages, ranging from 18% to 33% [14], or pass almost undisturbed into surface waters, due to the inadequate treatment procedure of wastewater treatment plants (WWTPs) [15][16][17]. They can therefore be considered as emerging pollutants and thus increase the risk of possible toxic effects on aquatic organisms and on human health [18][19][20][21][22]. Furthermore, the active metabolites of these drugs can be converted back into their precursors during the treatment processes, leading to a concentration of the precursor in the effluent greater than that of the influent [23,24].…”

Section: Introductionmentioning

confidence: 99%

Identification of Photodegradation Products of Escitalopram in Surface Water by HPLC-MS/MS and Preliminary Characterization of Their Potential Impact on the Environment

et al. 2022

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The study concerns the photodegradation of the antidepressant escitalopram (ESC), the S-enantiomer of the citalopram raceme, both in ultrapure and surface water, considering the contribution of indirect photolysis through the presence of nitrate and bicarbonate. The effect of nitrate and bicarbonate concentrations was investigated by full factorial design, and only the nitrate concentration resulted in having a significant effect on the degradation. The kinetics of ESC photodegradation is the pseudo-first-order (half-life = 62.4 h in ultrapure water and 48.4 h in lake water). The generation of transformation products (TPs) was monitored through a developed and validated HPLC-MS/MS method. Fourteen TPs were identified in ultrapure water (one of them, at m/z 261, for the first time) and other two TPs at m/z 327 (found for the first time in this study) were identified only in presence of a nitrate. Several TPs were the same as those formed during the photodegradation of citalopram. The photodegradation pathway of ESC and its mechanism of degradation in water is proposed. The method was applied successfully to the analyses of surface water samples, in which a few dozen of ng L−1 of ESC was determined together with the presence of TP2, TP5 and TP12. Finally, a preliminary in silico evaluation of the toxicological profile and environmental behavior of TPs by computational models was carried out; two TPs (TP4 and TP10) were identified as of potential concern, as they were predicted mutagenic by Ames test model.

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Living Organisms as Sensors for Biohybrid Monitoring Systems

Rajewicz

Helmer

Schmickl

et al. 2023

Lecture Notes in Computer Science

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Many aquatic habitats have become vulnerable to rapid and long-term changes induced by industrialism, air pollution, tourism, fishing activities etc. These factors created an urgent need for extensive water monitoring and conservation. By observing the behaviour of lifeforms, we can monitor the state of the environment. Here, we present the methodology, calibration approaches and preliminary results of designing a biohybrid entity for aquatic monitoring. Biohybrid robots combine mechanical and electronic elements with living organisms or tissues. This biohybrid consists of several modules, each hosting or attracting different species and communities. We focus on animals such as Daphnia sp., zebra mussel Dreissena polymorpha and various representatives of the plankton community. The first results showed that 1) both Daphnia and D. polymorpha show no clear signs of confinement-induced stress, 2) the designed structures are examples of suitable tools for hosting the organisms, observing their behaviour and collecting and storing data and 3) their behaviour can be calibrated under laboratory conditions to be able to extrapolate the field data into environmental data.

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Combined toxicity and toxicity persistence of antidepressants citalopram and mirtazapine to zooplankton Daphnia magna

Cited by 16 publications

References 39 publications

Developmental Defects in Cognition, Metabolic and Cardiac Function Following Maternal Exposures to Low Environmental Levels of Selective Serotonin Re-Uptake Inhibitors and Tributyltin in Daphnia Magna

Developmental Defects in Cognition, Metabolic and Cardiac Function Following Maternal Exposures to Low Environmental Levels of Selective Serotonin Re-Uptake Inhibitors and Tributyltin in Daphnia Magna

Identification of Photodegradation Products of Escitalopram in Surface Water by HPLC-MS/MS and Preliminary Characterization of Their Potential Impact on the Environment

Living Organisms as Sensors for Biohybrid Monitoring Systems

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