Combined transarterial chemoembolization and arterial administration of<i>Bletilla striata</i>in treatment of liver tumor in rats

Qian, Jun; Vossoughi, D.; Woitaschek, Dirk; Oppermann, Elsie; Bechstein, Wolf O.; Li, Weiyong; Gao, Feng; Vogl, Thomas J.

doi:10.3748/wjg.v9.i12.2676

Cited by 25 publications

(12 citation statements)

References 42 publications

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“…Today BsP is widely used in clinics and is administered through routes including external and internal application and arterial embolization, and there have been no reports of adverse reactions or toxicity. 6 Although the safety of BsP has not been explicitly tested in the past, our previous cytotoxicity and ocular irritation tests demonstrated that BsP is safe to use as a method of ophthalmic topical drug delivery.…”

Section: Introductionmentioning

confidence: 98%

Safety Evaluation of Intracameral and Subconjunctival Injection of a Novel Mucoadhesive Polysaccharide Isolated from Bletilla striata in Rabbit Eye

Yang²,

Jiang³

et al. 2012

Journal of Ocular Pharmacology and Therapeutics

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Section: Introductionmentioning

confidence: 98%

Safety Evaluation of Intracameral and Subconjunctival Injection of a Novel Mucoadhesive Polysaccharide Isolated from Bletilla striata in Rabbit Eye

Yang²,

Jiang³

et al. 2012

Journal of Ocular Pharmacology and Therapeutics

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“…BS angioembolus was used as an embolic material in intra-arterial hepatic chemoembolization (TACE) for hepatic cell carcinoma (HCC) (Zheng et al, 1998). The mechanisms of embolization by BS can be attributed to the following factors (Qian et al, 2003): non-absorbent property, total mechanical obstruction, the inhibition on angiogenesis and secondary obstruction due to injury of the wall of blood vessels. In addition BS could short prothrombin time (PT) and decrease activated partial thromboplastin time, and the degree of PT reduction was dependent on the composition ratio of polysaccharides from BS (Sun et al, 2006).…”

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confidence: 99%

Partial Splenic Embolization UsingBletilla striataParticles for Hypersplenism in Cirrhosis: A Prospective Study

Liu¹,

Teng²,

He³

et al. 2011

Am. J. Chin. Med.

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The article evaluates the long-term follow-up results of PSE using Bletilla striata (BS) particles for hypersplenism in cirrhosis, as compared to PSE using gelfoam particles. Fifty-nine patients with cirrhosis-induced hypersplenism were treated with PSE. The patients were randomly assigned into two groups: gelfoam group, which includes 32 patients using gelfoam particles as the embolic material, and BS group, which includes 27 patients using BS particles. The peripheral blood cell counts and parameters for complications associated with PSE were measured during the follow-up. The mean values of leukocyte and thrombocyte, but not hemoglobin, were significantly increased after PSE (p < 0.01) in both groups. The values of leukocyte and thrombocyte during the long-term follow-up were significantly improved in BS group than that in gelfoam group (both p < 0.01). The frequency of bleeding episodes from esophageal varices in both groups was significantly reduced after PSE (both p < 0.01), but the post-PSE bleeding episodes showed no remarkable differences between the two groups (p = 0.084). Post-embolization syndrome consisted mainly of fever, nausea and vomiting, and abdominal pain in the two groups. The incidence of grade II to III abdominal pain in BS group (82.8%, 27/33) was significantly higher than in gelfoam group (57.9%, 33/57) (p = 0.020). The mean survival time was 61.5 ± 9.1 (median 60, 1-157) months in gelfoam group and 63.4 ± 9.9 (median 52, 0-161) months in BS group, which showed no significant difference (p = 0.930). In conclusion, BS particles could be used as the embolic material in PSE. Compared to gelfoam used in PSE, BS can achieve even better efficacy in alleviating hypersplenism. It provides a long-term effect on the hematological parameters, bleeding from esophageal varices and good palliation, and improved clinical status contributing to symptomatic control.

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“…It has been used as a traditional medicine for treating various symptoms and conditions, including tuberculosis, hemoptysis, and gastric ulcer (Kong et al . 2003; Qian et al . 2003).…”

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confidence: 99%

“…is a terrestrial orchid that is native to eastern Asian countries. It has been used as a traditional medicine for treating various symptoms and conditions, including tuberculosis, hemoptysis, and gastric ulcer (Kong et al 2003;Qian et al 2003).A variety of compounds, such as the phenanthrene derivatives reported by Yamaki et al (1993), has been isolated from this species. It can be reproduced easily by seed germination, which characterizes it among many ornamental species of Orchidaceae (Nagashima 1982;1994).…”

mentioning

confidence: 99%

Contribution of militarine and dactylorhin A to the plant growth‐inhibitory activity of a weed‐suppressing orchid, Bletilla striata

Sakuno

Kamo²,

Takemura

et al. 2010

Weed Biology and Management

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The methanol extract of Bletilla striata, an ornamental orchid in eastern Asia, exhibited plant growth-inhibitory activity. It was purified by continuous chromatography, based on the inhibitory activity against the growth of lettuce seedlings, resulting in two glycosidic compounds, militarine and dactylorhin A.The EC50 values of militarine and dactylorhin A against the radicle elongation of the lettuce seedlings were 0.28 and 0.88 mmol L -1 , respectively.The amount of militarine and dactylorhin A in the methanol extract of the aerial part of B. striata was calculated to be 5.6 and 7.5 mg g -1 fresh weight, respectively. The inhibitory activity of militarine and its content in the methanol extract revealed that the plant growth-inhibitory activity of the extract of B. striata was mainly related to militarine. The inhibitory activity of militarine against the growth of Italian ryegrass and timothy were of the same level as that of lettuce.

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Combined transarterial chemoembolization and arterial administration ofBletilla striatain treatment of liver tumor in rats

Abstract: AIM:To evaluate and compare the effect of combined transarterial chemoembolization (TACE) and arterial administration of Bletilla striata (a Chinese traditional medicine against liver tumor) versus TACE alone for the treatment of hepatocellular carcinoma (HCC) in ACI rats.

Cited by 25 publications

References 42 publications

Safety Evaluation of Intracameral and Subconjunctival Injection of a Novel Mucoadhesive Polysaccharide Isolated from Bletilla striata in Rabbit Eye

Safety Evaluation of Intracameral and Subconjunctival Injection of a Novel Mucoadhesive Polysaccharide Isolated from Bletilla striata in Rabbit Eye

Partial Splenic Embolization UsingBletilla striataParticles for Hypersplenism in Cirrhosis: A Prospective Study

Contribution of militarine and dactylorhin A to the plant growth‐inhibitory activity of a weed‐suppressing orchid, Bletilla striata

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