Combined Treatment Modality in Small Cell Lung Cancer

Klautke, Günther; Sauer, Rolf; Fietkau, Rainer

doi:10.1007/s00066-008-1839-x

Cited by 14 publications

(13 citation statements)

References 40 publications

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“…NSCLC is of particular interest, because it is one of the most common cancer types [19]. Modern radiotherapy techniques, fractionation regimens, and novel anticancer drugs have been included in the treatment strategies and are the subject of many clinical studies in lung cancer patients [12,17,18,24,28]. In order to perform a proper stratification in clinical trials, it is important to identify key prognostic factors.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Impact of VEGF and VEGF Receptor 1 (FLT1) Expression in Patients Irradiated for Stage II/III Non-Small Cell Lung Cancer (NSCLC)

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Prognostic Impact of VEGF and VEGF Receptor 1 (FLT1) Expression in Patients Irradiated for Stage II/III Non-Small Cell Lung Cancer (NSCLC)

et al. 2010

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“…Most patients are treated with a multimodal approach consisting of platinum-based chemotherapy and local treatment, i.e., surgery or radiotherapy [10,12,19] due to the high frequency of metastases in patients with local treatment only. Efficacy of radio-or chemotherapy or both can be enhanced by hyperthermia.…”

Section: Introductionmentioning

confidence: 99%

Small Cell Carcinoma of Vulva

et al. 2010

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“…Conventional radiotherapy consists an effective modality for several human cancers (2,3). However, a dose escalation is often imperative to improve therapeutic outcome, with the cost of increased toxicity (4).…”

Section: Introductionmentioning

confidence: 99%

Genetic alterations after carbon ion irradiation in human lung adenocarcinoma cells

Fokas

You²,

Juricko³

et al. 2010

Int J Oncol

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Abstract. The aim of this study was to investigate the difference in gene expression profiles of human lung adenocarcinoma cells and identify genes whose expression is altered by heavy ions but not X-rays. The lung adenocarcinoma cell line A549 was irradiated with carbon ion beams and X-rays using biologically equivalent doses (2 Gy and 6 Gy, respectively). The transcriptional profiling was determined with a high density cDNA microarray containing 11.800 genes, and genetic network and gene ontology analysis was performed. The changes in selected genes involved were validated by quantitative real-time polymerase chain reaction (qRT-PCR). The microarray analysis identified 49 mapped, network-eligible genes, the expression level of which was altered by carbon ions but not by X-rays. From these, 29 were upregulated while 20 genes were downregulated 4 h postirradiation with carbon ions in A549 cells, as compared to the control. Among these, three genes (CCND2, RARG and E2F5) were involved in the aryl hydrocarbon receptor signalling and G1/S cell cycle checkpoint pathways. The microarray data were corroborated by qRT-PCR analysis of the selected genes (p<0.05). Our findings provide information on the genetic signature of carbon ions in human lung adenocarcinoma cells and add to the understanding of the complicated molecular response to carbon ion irradiation.

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Combined Treatment Modality in Small Cell Lung Cancer

Cited by 14 publications

References 40 publications

Prognostic Impact of VEGF and VEGF Receptor 1 (FLT1) Expression in Patients Irradiated for Stage II/III Non-Small Cell Lung Cancer (NSCLC)

Prognostic Impact of VEGF and VEGF Receptor 1 (FLT1) Expression in Patients Irradiated for Stage II/III Non-Small Cell Lung Cancer (NSCLC)

Small Cell Carcinoma of Vulva

Genetic alterations after carbon ion irradiation in human lung adenocarcinoma cells

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