Combined treatment of a solid tumour by local hyperthermia and actionomycin D

Abstract

Summary.-(BALB/c x C57BL/6)F1 mice bearing an SV-40 fibrosarcoma in the limb were injected with 0 045, 0-09 and 0.18 ,ug/g body wt actinomycin D into the tumour.Similar animals were also treated with local hyperthermia (39.70, 42 3°and 43-60C intratumour temperature for 30 min). The marked increase in median survival time following the combination of drug and local hyperthermia indicates that the combined treatment has a synergistic effect in the control of solid tumours. The median survival time of animals receiving the two treatments in immediate succession was higher than in animals with 30 min between treatments. This has important implications for the therapy of human cancer.

Triggered doxorubicin release in solid tumors from thermosensitive liposome-peptide hybrids: Critical parameters and therapeutic efficacy

“…Despite a decrease in the risk of drug‐associated toxicity and delivering more drug to the tumor tissue by encapsulation inside long‐circulating liposomes, the therapeutic efficacy of liposomal Doxorubicin (DOX) is not dramatically enhanced because of limited drug release from liposomes . Local hyperthermia represents one external trigger that can improve liposomal drug release by increasing their extravasation into the tumor, triggering content release and potentiating a chemotherapeutic effect …”

“…[3][4][5] Local hyperthermia 6 represents one external trigger that can improve liposomal drug release by increasing their extravasation into the tumor, 7 triggering content release 8 and potentiating a chemotherapeutic effect. 9 Different temperature-sensitive liposomes (TSL) have been developed following the original work by Yatvin and Weinstein. 10,11 This "traditional" TSL system has since been further developed for increased blood circulation half-life 12,13 and serum stability.…”

Behandlung konventionell inkurabler Tumorerkrankungen im Kindesalter mit Ganzkörperhyperthermie und Chemotherapie

“…Wschr. 114 (1989), 208-213 © Georg Thieme Verlag Stuttgart New York Die schon im vergangenen Jahrhundert gemachten klinischen Erfahrungen einer tumordestruierenden Wirkung supranormaler Temperaturen wurden inzwischen durch zahlreiche Untersuchungen an Tumorzellkulturen und vielen experimentellen Tumormodellen (7,8,16,19,22) sowie auch durch erste klinische Behandlungsergebnisse bestätigt (1,6,9,21,24,31,33,36,42). Der Erfolg der Hyperthermie ist von einer Reihe von Faktoren abhängig wie Höhe der Temperatur, Dauer der Einwirkung, Tumortyp, speziellen individuellen Faktoren, ob Hyperthermie mit Radiooder Chemotherapie kombiniert wird, und auch vom technischen Verfahren der Hitzeapplikation.…”