Combined treatment of aggressive central giant cell granuloma in the lower jaw

Rachmiel, Adi; Emodi, Omri; Sabo, Edmond; Aizenbud, Dror; Peled, Micha

doi:10.1016/j.jcms.2011.04.002

Cited by 46 publications

(43 citation statements)

References 32 publications

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“…Although there is not enough evidence that this lesion promotes reparative process, it was denominated reparative giant cell granuloma (2,(25)(26)(27)(28)(29)(30) . Based on differences in their histological pattern and clinical behavior, Jaffe separated maxillary CGCL from long bone giant cell tumor.…”

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

“…The latter lesions cause pain and exhibit rapid growth, usually larger than five centimeters, producing expansion and perforation of the cortical bone, displacement of teeth and root resorption. Besides, there is a high recurrence rate, which generally ranges between 37.5% and 70% (7,8,14,15,25,26,29,30,32,37) .…”

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

“…Intralesional injections of triamcinolone acetonide have also been prescribed in view of its anti-inflammatory and antiangiogenic properties. The combined treatment (pharmacological and surgical) is advantageous for large aggressive lesions insofar as it reduces their size, minimizing functional and physical imperfections (4,8,10,21,23,25,26,29) . The anti-angiogenic therapy in combination with curettage has proven to be a useful approach to the treatment of aggressive CGCL (25) .…”

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

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Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Vasconcelos

Vasconcelos²,

Queiroz

2013

J. Bras. Patol. Med. Lab.

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Introduction and objective: The peripheral and central giant cell lesions (PGCL and CGCL) are a group of pathological entities with similar histopathological features and whose origin has not been fully elucidated. The former is reactive and the latter exhibits a nonneoplastic proliferative behavior. This article aims to review the literature on peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) by discussing the most important aspects pertaining to each of them. Results: These lesions are found in different locations and show diverse clinical signs despite having the same histopathological features. The treatment consists in the surgical resection by different techniques depending on the type of the lesion and clinical conditions. In the case of CGCL, drug therapy may also be employed. Conclusion: Although there is no consensus in the literature, it is essential to know the etiology of these lesions as well as the exact origin of the giant cells. Due to their singular biological behavior, it is of utmost importance to establish a differential diagnosis between the two lesions and other processes that have similar clinical, radiological and histological characteristics, inasmuch as this procedure is essential to provide a suitable treatment and establish a prognosis.

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Section: Central Giant Cell Lesionsmentioning

confidence: 99%

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

Section: Central Giant Cell Lesionsmentioning

confidence: 99%

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Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Vasconcelos

Vasconcelos²,

Queiroz

2013

J. Bras. Patol. Med. Lab.

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“…Intralesional triamcinolone, alone or combined with denosumab, or interferon, was used to reverse the osteolytic effect of CGCG [4][5][6][7]. Other clinicians, however, have reported inaccurate information about treated cases of CGCG [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Idle gossip about validity of intralesional steroid injection in treating central giant cell granuloma

Alerraqi¹

2016

Horm Stud

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Treating central giant cell granuloma (CGCG) via intralesional injection of steroids was proven effective in some cases. Later, clinicians have preferred this treatment modality to surgical intervention for it avoids gnathic/bony disfigurement. Advocating this non-surgical therapy, several papers and reviews have recommended putting it into action as the first line of treatment, alone or combined with other treatment options, especially in treating aggressive CGCG. Other authors have reported inaccurate information to validate this approach. This paper scrutinizes, in retrospect, the infelicities about treating CGCG via intralesional injection of steroids and concludes that intralesional steroid injection is useful ONLY in treating non-aggressive CGCG and peripheral giant cell granulomas.

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“…Ayrıca görülme oranı mandibulada maksilladan daha fazladır [2][3][4] . Etiyolojisi tam olarak bilinmemekle birlikte, kemiğin travma, inflamasyon ya da hemorajiye karşı lokal reperatif bir reaksiyonu şeklinde düşünülür 5 . SDHG'nın klinik davranışı asemptomatik, yavaş büyüyen bir şişlikten; ağrı, kortikal destrüksiyon, kök rezorbsiyonu ve rekürrensle karakterize agresif bir lezyona doğru çeşitli değişiklikler göstermektedir 3,6,7 .…”

Section: Introductionunclassified

Santral Dev Hücreli̇ Granülomanin İli̇ak Greft Ve Hareketli̇ Yer Tutucu Aparey İle Rehabi̇li̇tasyonu: Olgu Sunumu

Damlar¹,

Altan²,

Yanık³

et al. 2015

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

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ÖZETAmaç: Santral dev hücreli granüloma sıklıkla mandibula ve maksillada lokalize olan, non-odontojenik patolojik bir lezyondur. Etiyolojisi tam olarak bilinmemektedir. Lezyonun cerrahi olarak uzaklaştırılması en çok uygulanan tedavi yöntemidir. Amacımız bu vakada santral dev hücreli granülomanın iliak greft ve hareketli yer tutucu aparey kullanılarak rehabilitasyonunu rapor etmektir. Vaka raporu: 10 yaşındaki erkek hasta kliniğimize mandibula anterior sol bölgede şişlik şikayetiyle başvurdu. Alınan anamnezde, şikayetin olduğu bölgeye yaklaşık 1 yıl önce cerrahi bir müdahale yapıldığı, fakat şişliğin altı ay önce tekrar oluştuğu öğrenildi. Genel anestezi altında lezyon çıkartıldı. Mandibular sol santral, lateral, kanin ve birinci premolar dişler çekildi. Mandibulada oluşan defekt iliak greftle onarıldı. Çıkarılan kitlenin histopatolojik incelemesi yapıldı ve santral dev hücreli granülom tanısı konuldu. Operasyon sonrası yapılan 12 aylık takipte herhangi bir problemle karşılaşılmadı. Daha sonra hastaya hareketli yer tutucu bir aparey yapıldı. Sonuç: Literatürde santral dev hücreli granülom gibi agresif lezyonların %72 rekürens oranı olduğu görül-mektedir. Rekürens gösteren vakalarda kortikostreoid enjeksiyonu, sistemik kalsitonin uygulaması gibi konservatif yöntemlerin başarısı kesin değildir. Cerrahi tedavi çene kemiklerinde major defektlere neden olabilir ve fasiyal konturu bozabilir. Böyle bir durumda defektin iliak greftle tamiri estetik problemleri çözecektir ve protezle rehabilitasyon imkanı sunacaktır. Anahtar kelimeler: santral dev hücreli granüloma, iliak greft, hareketli yer tutucu ABSTRACT Purpose: Central giant cell granuloma is a nonodontogenic pathological lesion that usually located in the mandible and maxilla. The aetiology of giant cell granuloma is undefined. Surgical removal is the most commonly applied therapy. Our aim was to report rehabilitation of central giant cell granuloma with iliac graft and removable space maintainer. Case Report: A 10-years-old child was referred to our clinic complaining of swelling in the mandibular anterior region. The parents of the patient were reported that a surgical operation was done in mandibular anterior region of the patient one year ago. They also reported that this lesion was recurred six months after first surgery. The recurred lesion was removed under general anesthesia, mandibular left central, lateral, canine and first premolar teeth were extracted. Iliac crest graft was harvested and fixed to the mandible. The histopathology report confirms the diagnosis of a central giant cell granuloma. The patient's postoperative 12 months follow-up exam was uneventful. The patient was referred for removable space maintainer. Conclusion: Aggressive lesions such as central giant cell granuloma observed 72% recurrence rate to the literature. Conservative methods such as corticosteroid injection, systemic calcitonin's success isn't definite on the recurred lesion. The surgical treatment may cause major defects in jaw bones and changes the facial contours, the repai...

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Combined treatment of aggressive central giant cell granuloma in the lower jaw

Cited by 46 publications

References 32 publications

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Idle gossip about validity of intralesional steroid injection in treating central giant cell granuloma

Santral Dev Hücreli̇ Granülomanin İli̇ak Greft Ve Hareketli̇ Yer Tutucu Aparey İle Rehabi̇li̇tasyonu: Olgu Sunumu

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