Combined treatment of olanzapine and mirtazapine in anorexia nervosa associated with major depression

Wang, Tzong-Shi; Chou, Yuan-Hwa; Shiah, I‐Shin

doi:10.1016/j.pnpbp.2005.10.004

Cited by 21 publications

(13 citation statements)

References 16 publications

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“…Olanzapine is the most studied antipsychotic, with 8 trials in adult AN patients (4 compared to placebo, 1 to chlorpromazine, 2 open label, and 1 retrospective study) [42][43][44][45][46][47][48][49] and 4 case reports involving adult patients. [50][51][52][53] The first 10-week, open-label trial examined the efficacy and safety of olanzapine 10 mg daily in 18 patients (2 male) with AN, with 10 patients gaining weight. 42 Again, 17 AN women received olanzapine 2.5-7.5 mg daily (mean 4.7) in an open-label fashion, and were evaluated at baseline and every 2 weeks.…”

Section: Antipsychoticsmentioning

confidence: 99%

Psychopharmacological options for adult patients with anorexia nervosa

et al. 2015

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The aim of this review was to summarize evidence from research on psychopharmacological options for adult patients with anorexia nervosa (AN). Database searches of MEDLINE and PsycINFO (from January 1966 to January 2014) were performed, and original articles published as full papers, brief reports, case reports, or case series were included. Forty-one papers were screened in detail, and salient characteristics of pharmacological options for AN were summarized for drug classes. The body of evidence for the efficacy of pharmacotherapy in AN was unsatisfactory, the quality of observations was questionable (eg, the majority were not blinded), and sample size was often small. More trials are needed, while considering that nonresponse and nonremission are typical of patients with AN.

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Section: Antipsychoticsmentioning

confidence: 99%

Psychopharmacological options for adult patients with anorexia nervosa

et al. 2015

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“…29 Thus, several symptoms in patients with anorexia nervosa are related to low leptin levels, such as hypothalamic amenorrhoea and physical hyperactivity. 30 There is evidence from case reports that a combination of olanzapine with mirtazapine alone 31 or together with a selective serotonin reuptake inhibitor 32 can be helpful, particularly in patients with comorbid major depression. However, there is a lack of randomized controlled trials proving beneficial effects of antipsychotics or antidepressants in anorexia nervosa.…”

Section: Native Ct Of Two Transverse Sections Of the Brain In A Caudamentioning

confidence: 99%

Nature Against Nurture: Calcification in the Right Thalamus in a Young Man with Anorexia Nervosa and Obsessive-Compulsive Personality Disorder

Conrad¹,

Wegener²,

Geiser³

et al. 2008

CNS spectr.

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This report describes the case of a young man with a large calcification in the right thalamus that was first diagnosed at 9 years of age. Case history reveals specific eating rituals and other obsessive-compulsive personality traits during the patient's childhood and adolescence, fulfilling diagnostic criteria of obsessive-compulsive personality disorder. After a critical life event the patient develops anorexia nervosa. We suggest that our case and further literature provide evidence for an involvement of specific thalamic structures, such as the dorsomedial nucleus, in the development of anorexia nervosa. Furthermore, the treatment of the patient by a combined psychotherapeutic and pharmacotherapeutic approach is described. We focus on the beneficial effect of the atypical antipsychotic olanzapine, which can induce weight gain by an increase of leptin levels.

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“…[5][6][7] Recently, there has been interest in the use of atypical antipsychotics for the treatment of AN, prompted in part by observations of weight gain in other patient groups. This has resulted in case reports and open trials that raise the possibility that olanzapine, [8][9][10][11][12][13][14][15][16][17][18][19][20][21] quetiapine, [22][23][24] risperidone, 25,26 and most recently aripiprazole 27 may have some efficacy in AN. A randomized, placebo-controlled trial of olanzapine in 34 individu-als with AN treated in a day hospital setting showed improved rate of weight gain and reduced obsessional symptoms.…”

Section: Introductionmentioning

confidence: 99%

Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa

Duvvuri¹,

Cromley²,

Klabunde³

et al. 2011

Intl J Eating Disorders

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Objective No studies have compared the response to selective serotonin reuptake inhibitors and atypical antipsychotics in anorexia nervosa. This case study examines such a comparison. Method This report describes a case of 12-year-old identical twins with anorexia nervosa, one of whom was treated with olanzapine and the other with fluoxetine, while undergoing family therapy. Results Twin A treated with fluoxetine went from 75% to 84.4% ideal body weight, while Twin B treated with olanzapine went from 72% to 99.9% ideal body weight over the course of 9 months. Discussion This case supports the need for adequately powered, controlled clinical trials to test the efficacy of olanzapine in adolescents presenting with anorexia nervosa.

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Combined treatment of olanzapine and mirtazapine in anorexia nervosa associated with major depression

Cited by 21 publications

References 16 publications

Psychopharmacological options for adult patients with anorexia nervosa

Psychopharmacological options for adult patients with anorexia nervosa

Nature Against Nurture: Calcification in the Right Thalamus in a Young Man with Anorexia Nervosa and Obsessive-Compulsive Personality Disorder

Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa

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