2017
DOI: 10.3892/mmr.2017.7984
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Combined treatment with extracorporeal shock‑wave therapy and bone marrow mesenchymal stem cell transplantation improves bone repair in a rabbit model of bone nonunion

Abstract: The aim of the present study was to analyze whether extracorporeal shock‑wave therapy (ESWT) combined with bone marrow mesenchymal stem cell (BMMSC) transplantation improves bone repair in a rabbit bone nonunion model. ESWT combined with BMMSC effectively enhanced mechanical strength, fracture stiffness and histological scores, and increased alkaline phosphatase activity, and osteopontin, runt related transcription factor 2 and collagen type I α1 chain protein expression levels in a rabbit bone nonunion model.… Show more

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Cited by 3 publications
(2 citation statements)
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“…Additionally, vascular endothelial growth factor (VEGF) [81] related mechanisms are postulated to be involved in this process. Moreover, since SWT can activate stem cells [82][83][84], along with the ongoing development of this treatment method, a potentially wide range of applications in the different fields of regenerative medicine can be applied [85][86][87][88]-not only those related to the central or peripheral nervous system.…”
Section: Neurologymentioning
confidence: 99%
“…Additionally, vascular endothelial growth factor (VEGF) [81] related mechanisms are postulated to be involved in this process. Moreover, since SWT can activate stem cells [82][83][84], along with the ongoing development of this treatment method, a potentially wide range of applications in the different fields of regenerative medicine can be applied [85][86][87][88]-not only those related to the central or peripheral nervous system.…”
Section: Neurologymentioning
confidence: 99%
“…Also, transplantation of cell sheets of rat BM-MSCs into a non-union femur fracture rat model showed bone union in eight weeks [ 116 ]. Likewise, BM-MSCs, when combined with extracorporeal shock-wave therapy in a rabbit model of nonunion bone fracture, improved fracture stiffness, mechanical strength, and histological scores [ 117 ]. Finally, injection of exosomes derived from BM-MSCs into the site of the nonunion femoral bone fracture rat model once every week enhanced osteogenesis, bone healing processes, and angiogenesis [ 38 ].…”
Section: Introductionmentioning
confidence: 99%