Combined treatment with fractional carbon dioxide laser, autologous platelet‐rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: A prospective, randomized comparative trial

Abdelghani, Rania; Ahmed, Naglaa A.; Darwish, Hanan M.A.

doi:10.1111/jocd.12397

Cited by 61 publications

(104 citation statements)

References 33 publications

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“…Overall, the improvement in vitiligo lesions observed using CO 2 , needling, peeling and PRP supports the idea that dermal stimulation can be useful in the induction of repigmentation even if controlled randomized studies are needed to confirm the efficacy and safety of these approaches.…”

Section: Proposed Treatmentssupporting

confidence: 55%

Involvement of non‐melanocytic skin cells in vitiligo

Bastonini

Bellei

Filoni

et al. 2019

Experimental Dermatology

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Despite melanocytes are the key players in vitiligo, a continuous cross‐talk between epidermal and dermal cells may strictly affect their functionality, in both lesional skin and non‐lesional skin. Focusing on this interplay, we have reviewed existing literature supporting evidence on cellular and functional alterations of surrounding epidermal keratinocytes, extracellular matrix (ECM) proteins and fibroblasts in the underlying dermal compartment that may contribute to melanocyte disappearance in vitiligo. We have also examined some clinical and therapeutic aspects of the disease to sustain the non‐exclusive involvement of melanocytes within vitiligo. As a result, a different and more complex scenario has appeared that may enable to provide better understanding about origins and progress of vitiligo and that should be considered in the evaluation of new treatment approaches.

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Section: Proposed Treatmentssupporting

confidence: 55%

Involvement of non‐melanocytic skin cells in vitiligo

Bastonini

Bellei

Filoni

et al. 2019

Experimental Dermatology

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“…However, a combination of PRP with NBUVB induced statistically significant repigmentation in a series of 60 patients from Egypt . In a prospective randomized controlled trial comparing fractional CO2, PRP, NBUVB, combined fractional CO2 and PRP, combined fractional CO2 laser and NBUVB done in Egypt, the laser and PRP group achieved best results regarding repigmentation and patient satisfaction …”

Section: Discussionmentioning

confidence: 97%

Use of platelet‐rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double‐blind randomized controlled trial

et al. 2018

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Background Noncultured epidermal cell suspension (NCES) is an effective surgical modality for stable vitiligo which involves transplantation of the basal layer of epidermal cells onto the dermabraded vitiliginous patch. Platelet-rich plasma (PRP) has growth factors which may stimulate melanocyte migration and proliferation of keratinocytes and fibroblasts. The objective of this study was to compare the extent of repigmentation achieved by transplantation of NCES suspended in PRP with that of NCES suspended in phosphate buffered saline (PBS).Methods Twenty-one patients of stable vitiligo with at least two lesions of comparable size were included. The two vitiligo patches were randomized to receive NCES suspended in PRP or PBS. Postoperatively after 1 week, patients were given heliotherapy for 15 minutes daily.Results At 6 months follow-up, mean repigmentation by area method in PRP arm was 75.6 AE 30% SD and in non-PRP arm was 65 AE 34% SD (P = 0.0036). Patient satisfaction by visual analogue scale at 6 months also showed better results in PRP arm (P = 0.001).Assessment by three independent observers showed better repigmentation in PRP side both at 3 and 6 months.Conclusions Suspending NCES in PRP can result in significantly greater mean repigmentation and patient satisfaction than suspending in PBS.

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“…However, the study mainly refers to the efficacy of combined treatment (fractional laser combined with tacrolimus) by which we can remedy the abovementioned three main drawbacks of present treatment on vitiligo. According to our clinical experience and previous researches, the efficacy of the treatment of vitiligo by CO 2 fractional laser alone is limited [31,32]. We consider that although single CO 2 treatment can promote the proliferation of melanocytes, but the inappropriate microenvironment in vivo makes these cells hard to survive.…”

Section: Discussionmentioning

confidence: 99%

Preliminary study on the treatment of vitiligo with carbon dioxide fractional laser together with tacrolimus

et al. 2018

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The treatment of vitiligo by CO fractional laser together with tacrolimus is significantly effective and is most suitable for patients in the progression stage. Patients in the rapid progression stage should use this approach with caution, and its efficacy was limited for patients in the stable stage. An extended course of treatment is helpful for the repigmentation of white patches. All three forms of repigmentation can occur in the joint treatment of vitiligo by CO fractional laser together with tacrolimus. Lasers Surg. Med. 50:829-836, 2018. © 2018 Wiley Periodicals, Inc.

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Combined treatment with fractional carbon dioxide laser, autologous platelet‐rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: A prospective, randomized comparative trial

Abstract: Combination of fractional CO laser with PRP injection is a promising treatment for vitiligo, followed by combination of fractional CO laser with NB-UVB phototherapy. Both fractional CO laser and PRP injection gave poor results if they received alone.

Cited by 61 publications

References 33 publications

Involvement of non‐melanocytic skin cells in vitiligo

Involvement of non‐melanocytic skin cells in vitiligo

Use of platelet‐rich plasma to suspend noncultured epidermal cell suspension improves repigmentation after autologous transplantation in stable vitiligo: a double‐blind randomized controlled trial

Preliminary study on the treatment of vitiligo with carbon dioxide fractional laser together with tacrolimus

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