Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats

Oliveira, Ariclécio Cunha de; Andreotti, Sandra; Sertié, Rogério Antônio Laurato; Campaña, Amanda Baron; Proença, André Ricardo Gomes de; Vasconcelos, Raimundo Pereira de; Oliveira, Keciany Alves de; Coelho‐de‐Souza, Andrelina Noronha; Donato-Junior, Jose; Lima, Fábio Bessa

doi:10.1016/j.lfs.2018.02.040

Cited by 24 publications

(23 citation statements)

References 27 publications

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“…The results clearly demonstrated that the large production of melatonin in SD inhibits ARC Kiss1 expression, this effect being further modulated by the negative sex steroid feedback, whereas the melatonin‐driven change in AVPV Kiss1 only depends on the positive sex steroid feedback. A similar inhibitory effect of melatonin on Kp expression was also reported in the Turkish (Piekarski et al., ) and striped (Li et al., ) hamster and even in the rat (de Oliveira et al., ). Although a direct effect of melatonin on Kp expression in a hypothalamic cell line has been reported (Gingerich et al., ), in vivo studies have demonstrated that ARC Kp neurons do not express MT1 (Li, Rao, Pereira, Clarke, & Smith, ).…”

Section: Role Of Kisspeptin In Mammalian Seasonal Reproductionsupporting

confidence: 74%

A Kiss to drive rhythms in reproduction

Simonneaux

2018

Eur J of Neuroscience

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Reproduction, like many other biological functions, exhibits marked daily and seasonal rhythms in order to anticipate and adapt breeding activity to environmental challenges. In recent years, studies investigating the neuroendocrine mechanisms driving rhythms in reproduction have unveiled the pivotal role of hypothalamic neurons expressing kisspeptin in integrating and forwarding daily and seasonal cues to the reproductive system. The objective of this review is to summarize the knowledge on the effect and role of this neuropeptide on the mammalian hypothalamo‐pituitary‐gonadal axis and describe how it is involved in the daily control of ovulation in females and long‐term adaptation of reproduction in seasonal breeders.

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Section: Role Of Kisspeptin In Mammalian Seasonal Reproductionsupporting

confidence: 74%

A Kiss to drive rhythms in reproduction

Simonneaux

2018

Eur J of Neuroscience

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“…Melatonin in pharmacological concentration could improve iNOS and SOD activity in hyperglyceamic human dental pulp cells (hDPCs), suggesting the protective effects of melatonin in human dental pulp tissue under hyperglycaemia [58]. In rats with streptozotocin (STZ)-induced diabetes, eight-week treatment with insulin (NPH, 1.5 U/100gr/day) and melatonin (0.2 mg/kg/day in drinking water) improves glucose homeostasis and insulin sensitivity of white adipose tissue comparing with using one of these drugs individually [59]. The production of melatonin has been reported to reduce in animal models of diabetes and melatonin treatment (100 mg/kg/day in drinking water for 8 weeks) in high-fat diet-fed mouse with insulin resistance results in better glucose tolerance [60].…”

Section: Anti-diabetic Effects Of Melatoninmentioning

confidence: 99%

Melatonin: new insights on its therapeutic properties in diabetic complications

Pourhanifeh

Hosseinzadeh

Dehdashtian

et al. 2020

Diabetol Metab Syndr

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Diabetes and diabetic complications are considered as leading causes of both morbidity and mortality in the world. Unfortunately, routine medical treatments used for affected patients possess undesirable side effects, including kidney and liver damages as well as gastrointestinal adverse reactions. Therefore, exploring the novel therapeutic strategies for diabetic patients is a crucial issue. It has been recently shown that melatonin, as main product of the pineal gland, despite its various pharmacological features including anticancer, anti-aging, antioxidant and antiinflammatory effects, exerts anti-diabetic properties through regulating various cellular mechanisms. The aim of the present review is to describe potential roles of melatonin in the treatment of diabetes and its complications.

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“…39 Additionally, the combined treatment of melatonin and insulin improved glycemic control and enhanced the reproductive fitness of diabetic male rats. 40 Furthermore, high levels of melatonin, induced by cold temperature, improved the immunoresponses and survival chance of Golden hamster males (Mesocricetus auratus) during cold weather. 41 Endogenous melatonin levels can be affected by several environmental factors.…”

Section: Of 19 |mentioning

confidence: 99%

“…Recently, it has been shown that the exogenous melatonin treatment decreased the abamectin‐induced toxicity in the cotton leafworm, Spodoptera litura (Lepidoptera: Noctuidae) . Additionally, the combined treatment of melatonin and insulin improved glycemic control and enhanced the reproductive fitness of diabetic male rats . Furthermore, high levels of melatonin, induced by cold temperature, improved the immunoresponses and survival chance of Golden hamster males ( Mesocricetus auratus ) during cold weather …”

Section: Introductionmentioning

confidence: 99%

Infection with phytopathogenic bacterium inhibits melatonin biosynthesis, decreases longevity of its vector, and suppresses the free radical‐defense

Nehela

Killiny

2018

Journal of Pineal Research

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Vector-borne phytopathogenic bacteria may alter the reproductive fitness, survival, behavior, and metabolism of their vectors. Candidatus Liberibacter asiaticus (CLas) is associated with the Huanglongbing (also known as citrus greening disease), one of the most destructive citrus diseases worldwide, and transmitted by Asian citrus psyllid, Diaphorina citri (Insecta, Hemiptera, Liviidae). The genome sequencing of CLas revealed that it does not have the ability to synthesize tryptophan, the precursor of melatonin, and it must acquire it from its host plant or insect vector to achieve its biologic processes, such as growth and multiplication. Herein, we aimed to develop a GC-MS-SIM-based method to detect the endogenous melatonin from small insects such as D. citri, and to explore the hidden relationship between melatonin content and D. citri-adult survival. Then, we studied the ability of exogenous melatonin supplementation to reverse the negative effects of CLas-infection. Our findings showed that CLas-infection reduced the levels of melatonin and its biosynthetic genes (DcTPHs, DcAAAD, DcSNAT, and DcASMT) of D. citri compared to uninfected insects. In addition, CLas decreased the longevity of its vector, D. citri via the suppression of the free radical-defense associated genes (SODs, GSTs, PODs, and PHGPXs). On the other hand, melatonin supplementation could reverse the negative effects of CLas-infection. Melatonin supplementation enhanced the endogenous melatonin content, melatonin biosynthetic genes, free radical-defense associated genes, and the longevity of both healthy and CLas-infected D. citri. Furthermore, melatonin supplementation decreased the CLas bacterial population within the D. citri psyllids. Based on these findings, we hypothesize that melatonin plays multi-layered defensive roles in D. citri. These roles include acting as a natural antioxidant or as an antibacterial compound.

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Combined treatment with melatonin and insulin improves glycemic control, white adipose tissue metabolism and reproductive axis of diabetic male rats

Cited by 24 publications

References 27 publications

A Kiss to drive rhythms in reproduction

A Kiss to drive rhythms in reproduction

Melatonin: new insights on its therapeutic properties in diabetic complications

Infection with phytopathogenic bacterium inhibits melatonin biosynthesis, decreases longevity of its vector, and suppresses the free radical‐defense

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