Combined treatment with vitamins E and C in experimental myocardial infarction in pigs

Klein, Hermann H.; Pich, Sibylle; Lindert, S.; Nebendahl, Klaus; Niedmann, Paul Dieter; Kreuzer, H

doi:10.1016/0002-8703(89)90577-2

Cited by 79 publications

(20 citation statements)

References 39 publications

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“…Therefore, the antiatherosclerotic effect of vitamin E is strongest at the point of initiation (primary prevention) than in an already established atherosclerotic lesion (secondary prevention) [145,164]. This hypothesis is in agreement with results obtained by Klein et al in a study to assess the effect of two different combined treatments with vitamin E acetate and vitamin C on infarct size and recovery of regional myocardial function [165]. Initiation of treatment before the onset of ischemia resulted in a greater reduction in infarct size and better recovery of regional myocardial function than initiation of treatment during ischemia.…”

Section: Vitamin E Deficiency and Cvdsupporting

confidence: 89%

“…It decreases the secretion of IL-1, reduces platelet adhesion and aggregation [166], decreases monocyte endothelial cell adhesion, and inhibits thrombin formation [165]. Thus, vitamin E intake may have a greater protective effect against the onset of primary atherosclerotic lesions (identified using imaging criteria as endpoints) in younger individuals with a CHD-free background and a prolonged period of intake (>10 years) than in older individuals with pre-existing atherosclerotic lesions, a high CHD risk background, and with short duration of therapy (<5 years) using clinical event endpoints [145], as characteristic of most clinical trials and secondary prevention studies.…”

Section: Vitamin E Deficiency and Cvdmentioning

confidence: 99%

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Micronutrient Vitamin Deficiencies and Cardiovascular Disease Risk: Advancing Current Understanding

Ekpenyong¹

2017

EJPM

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Cardiovascular diseases are responsible for one-third of all deaths in the world. Several factors contribute to the current trend including micronutrient vitamin deficiencies (MVDs), however, opinions regarding the role of MVDs in CVDs are inconsistent; this could impact on micronutrient vitamins intake. The aim of this review was to provide a brief overview of published evidence on the associations between MVDs and CVDs, assess the interactions between micronutrients and cardiovascular endpoints, and identify current related research needs. Literature search conducted on studies published between 1963 and 2016 indicates that MVDs are common and are related to adverse cardiovascular endpoints through various mechanisms, including impaired antioxidant and immune response mechanisms; and anti-inflammatory activities. Some micronutrients directly impact on CVDs; others act as critical cofactors in several biochemical processes. Several methodologic flaws, environmental and individual susceptibility factors, lack of determination of baseline serum levels of complementary micronutrients, absence of uniformly accepted cut-off values, and interactions between micronutrients may partly account for discordant results across studies. Although MVD is a significant risk factor for CVDs, supplementation with single or paired micronutrients for primary prevention of CVDs in healthy adults with no special nutritional needs is discouraged; there is insufficient evidence to determine the benefit/harm of such supplementation.

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Section: Vitamin E Deficiency and Cvdsupporting

confidence: 89%

Section: Vitamin E Deficiency and Cvdmentioning

confidence: 99%

Micronutrient Vitamin Deficiencies and Cardiovascular Disease Risk: Advancing Current Understanding

Ekpenyong¹

2017

EJPM

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“…vitamin E limited myocardial necrosis [65][66][67], while Clinical trials examining the beneficial effects of vitamin combined pretreatment with vitamins E and C in is-E and other antioxidant vitamins in different settings of chemia-reperfusion settings was found to protect the heart failure have been undertaken. Vitamin E treatment in myocardium and decrease the resultant infarct size in pigs atherosclerotic patients reduced the rate of nonfatal [68]. myocardial infarction [93].…”

Section: Cardiovascular Conundra Seriesmentioning

confidence: 99%

The role of oxidative stress in the genesis of heart disease

Singal

Khaper

Palace

et al. 1998

Cardiovascular Research

303

149

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Although researchers in radiation and cancer biology have known about the existence of free radicals and their potential role in pathobiology for several decades, cardiac biologists only began to take notice of these noxious species in the 1970s. Exponential growth of free radical research occurred after the discovery of superoxide dismutase in 1969. This antioxidant enzyme is responsible for the dismutation of superoxide radical -a free radical chain initiator. A fine balance between free radicals and a variety of endogenous antioxidants is believed to exist. Any disturbance in this equilibrium in favour of free radicals causes an increase in oxidative stress and initiates subcellular changes leading to cardiomyopathy and heart failure. Our knowledge about the role of free radicals in the pathogenesis of cardiac dysfunction is fast approaching the point where newer therapies employing antioxidants are in sight.

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“…Whereas both experimental and epidemiological studies convincingly show the beneficial effects of vitamins C and E in patients with ischaemic heart disease [1], MI [2] and DM [3], the majority of clinical studies demonstrate contrary results [4, 5]. Clinical benefits were reported in only a few papers [6, 7] including our own [8,9,10].…”

Section: Introductionmentioning

confidence: 84%

Effects of Vitamins C and E on the Outcome after Acute Myocardial Infarction in Diabetics: A Retrospective, Hypothesis-Generating Analysis from the MIVIT Study

et al. 2008

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Background: There is significant evidence that reactive oxygen species play an important role in endothelial dysfunction, ischemia/reperfusion injury as well as in the pathogenesis of diabetes mellitus (DM). It is also known that vitamins C and E have substantial antioxidant properties. However, clinical evidence concerning this topic is insufficient so far. The aim of the present study was to determine if the administration of vitamins C and E influences the outcome in diabetic patients with acute myocardial infarction (AMI). Methods: Among 800 patients with AMI included in the MIVIT (Myocardial Infarction and Vitamins) study, 122 patients (15%) had confirmed DM. A retrospective analysis of the influence of vitamins C and E on 30-day cardiac mortality in patients with or without DM was performed. Results: There was a significant reduction in 30-day cardiac mortality in diabetic patients treated with antioxidant vitamins C and E [5 (8%) vs. 14 (22%); OR 0.32, 95% CI 0.11–0.93; p = 0.036]. Such an effect has not been observed in patients without DM [19 (6%) vs. 19 (6%); OR 0.97, 95% CI 0.51–1.85; p = 0.94]. Conclusion: The results suggest that early administration of antioxidant vitamins C and E in patients with AMI and concomitant DM reduces cardiac mortality.

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Combined treatment with vitamins E and C in experimental myocardial infarction in pigs

Cited by 79 publications

References 39 publications

Micronutrient Vitamin Deficiencies and Cardiovascular Disease Risk: Advancing Current Understanding

Micronutrient Vitamin Deficiencies and Cardiovascular Disease Risk: Advancing Current Understanding

The role of oxidative stress in the genesis of heart disease

Effects of Vitamins C and E on the Outcome after Acute Myocardial Infarction in Diabetics: A Retrospective, Hypothesis-Generating Analysis from the MIVIT Study

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