Combined Treatments with Photodynamic Therapy for  Non-Melanoma Skin Cancer

Lucena, Silvia Rocío; Salazar, Nerea; Gracia‐Cazaña, Tamara; Zamarrón, Alicia; González, Salvador; Juarranz, Ángeles; Gilaberte, Yolanda

doi:10.3390/ijms161025912

Cited by 125 publications

(81 citation statements)

References 104 publications

(121 reference statements)

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“…These cells in the skin occasionally change and do not behave normally, resulting in precancerous conditions. As a consequence, there is a high chance that these abnormal cells will become cancerous (11). MSC is a result of the transformation of skin melanocytes.…”

Section: Introductionmentioning

confidence: 99%

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

et al. 2017

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Abstract. Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument. The results, which are presented in the current study, showed the association between NMSC and MSC rates, and the time required to produce 1,000 IU vitamin D with latitudinal variation. Solar UV index (UVI) levels reported in 6 cities from the north to the south of Chile indicated that the UVI ratio of monthly mean values was 1.8 times higher in Arica than in Punta Arenas in January (summer in Chile), whereas it was 14 times higher in June (winter). This factor is an important consideration, since vitamin D synthesis is directly associated with the exposure of individuals to solar UVB radiation. A similar trend was observed in Antofagasta, Santiago, Concepcion, Valdivia and Punta Arenas. It can be concluded from these data that there is a direct association between NMSC rates and mortality, and UVB radiation, meaning that this type of cancer would not depend on vitamin D synthesis and therefore on calcium uptake. By contrast, MSC rates increased with decreased levels of vitamin D, and thus calcium uptake, in all cities, with the only exception being Punta Arenas.

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Section: Introductionmentioning

confidence: 99%

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

et al. 2017

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“…11 We judged the applicability within and across studies with reference to demographics of enrolled participants, the location and severity of the lesions, and the availability of treatments.…”

Section: Data Synthesis and Grading The Strength Of Evidence (Soe)mentioning

confidence: 99%

“…Surgical management is used most commonly, followed by radiation. [10][11][12] In individuals over 65, surgery is used to treat 61 percent of keratinocyte carcinomas (excision 42% and Mohs micrographic surgery 19%) followed by electrodessication and curettage (39%). 13 Specific surgical techniques include simple surgical excision with prespecified margins, surgery with intra-operative margin control (e.g.…”

Section: Introduction Backgroundmentioning

confidence: 99%

Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin

Drucker¹,

Adam²,

Langberg³

et al. 2017

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Key MessagesPurpose of Review Assess comparative effectiveness and safety of treatments for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Key Messages• Comparative evidence on treatment of BCC and SCC is limited. Many comparisons were evaluated in one or two randomized controlled trials only.• Surgery and radiotherapy have lower recurrence rates for BCC than interventions that destroy lesions with heat or cold, photodynamic therapy (PDT), or curettage.• There is moderate confidence that PDT for BCC is associated with better cosmetic outcomes than surgery.• Serious adverse events, events leading to treatment discontinuation, and treatment site infections were uncommon with all treatments for BCC.• Recurrence rates for SCC in situ were lower with PDT and cryotherapy than with drugs.Evidence was insufficient to draw conclusions for other treatments.ii This report is based on research conducted by the Brown Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2015-00002-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report.The information in this report is intended to help health care decisionmakers-patients and clinicians, health system leaders, and policymakers, among others-make well-informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.This report is made available to the public under the terms of a licensing agreement between the author and the Agency for Healthcare Research and Quality. This report may be used and reprinted without permission except those copyrighted materials that are clearly noted in the report. Further reproduction of those copyrighted materials is prohibited without the express permission of copyright holders.AHRQ or U.S. Department of Health and Human Services endorsement of any derivative products that may be developed from this report, such as clinical practice guidelines, other quality enhancement tools, or reimbursement or coverage policies, may not be stated or implied. This report may periodically be assessed for the currency of conclusions. If an assessment is done, the resulting surveillance report describing the methodology and findings will be found on the Effective Health Ca...

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“…Photodynamic inactivation (PDI) has attracted considerable research interest and has been successfully used for treating tumors and for sterilization. (8)(9)(10) It has also been used for sterilizing wounds to eliminate Escherichia coli or oral pathogens. (11,12) This approach does not require medication, and hence, does not generate drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Photodynamic Inactivation Efficiency Using Conventional and Decorative Light-Emitting Diode Lamps

2017

Sensors and Materials

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We studied the bacterial inactivation effects of conventional and decorative light-emitting diode (LED) lamps. We used erythrosine and toluidine blue O as photosensitizers, mixed them with bacteria, painted the mixture on nutrient agar (NA), and then irradiated the NA with commercial green, red, and white LED lamps. The experimental results showed a positive photodynamic inactivation effect on Escherichia coli and Staphylococcus aureus reduction in the experiment. Thus, we demonstrated a decrease in the in vitro growth of E. coli and S. aureus by using easily available LED lamps. This experiment revealed the possibility of using conventional and decorative lighting for daily bacterial inactivation in the future.

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Combined Treatments with Photodynamic Therapy for Non-Melanoma Skin Cancer

Cited by 125 publications

References 104 publications

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude

Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin

Evaluation of Photodynamic Inactivation Efficiency Using Conventional and Decorative Light-Emitting Diode Lamps

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