Combined Usage of Stem Cells in End‐Stage Heart Failure Therapies

Wang, Xintong; Zachman, Angela L.; Haglund, Nicholas; Maltais, Simon; Sung, Hak Joon

doi:10.1002/jcb.24782

Cited by 9 publications

(3 citation statements)

References 91 publications

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“…Alternative therapeutic options for end-stage HF have been used, including stem cell therapies, passive restraining devices, and direct cardiac compression devices (33)(34)(35)(36). Although the use of stem cells and biological agents for cardiac regeneration has shown promising results in both animal studies and clinical trials, remaining challenges include engraftment, mobilization, and poor survival of stem cells (33,37). Passive ventricular restraint devices have mostly targeted HF in the LV, and the long-term benefits for such an approach remain to be studied (35).…”

Section: Introductionmentioning

confidence: 99%

Soft robotic ventricular assist device with septal bracing for therapy of heart failure

et al. 2017

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Previous soft robotic ventricular assist devices have generally targeted biventricular heart failure and have not engaged the interventricular septum that plays a critical role in blood ejection from the ventricle. We propose implantable soft robotic devices to augment cardiac function in isolated left or right heart failure by applying rhythmic loading to either ventricle. Our devices anchor to the interventricular septum and apply forces to the free wall of the ventricle to cause approximation of the septum and free wall in systole and assist with recoil in diastole. Physiological sensing of the native hemodynamics enables organ-in-the-loop control of these robotic implants for fully autonomous augmentation of heart function. The devices are implanted on the beating heart under echocardiography guidance. We demonstrate the concept on both the right and the left ventricles through in vivo studies in a porcine model. Different heart failure models were used to demonstrate device function across a spectrum of hemodynamic conditions associated with right and left heart failure. These acute in vivo studies demonstrate recovery of blood flow and pressure from the baseline heart failure conditions. Significant reductions in diastolic ventricle pressure were also observed, demonstrating improved filling of the ventricles during diastole, which enables sustainable cardiac output.

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Section: Introductionmentioning

confidence: 99%

Soft robotic ventricular assist device with septal bracing for therapy of heart failure

et al. 2017

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“…[14] By this way, vessels, liver cells, myocytes and osteoblasts can be produced in culture [15] for the treatment of diseases such as large bone defects. [16][17][18][19]…”

Section: Adult Stem Cellsmentioning

confidence: 99%

Anatomy of stem cells

Kurt¹,

Aydemir²,

Özkut³

et al. 2015

Anatomy

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Stem cells are pluripotent cells that proliferate indefinitely with appropriate growth factor and nutrients, and appropriate environment. Stem cells have been believed to originate from primordial germ cells which normally produce the sperm or oocyte. These cells differentiate to all types cells types of mature tissues, into all derivatives of the three primary germ layers: ectoderm, endoderm and mesoderm. Stem cells can be categorized according to their potential to differentiate into different cell types such as totipotent which can give rise to a complete and functional organism, and pluripotent which can give rise to every cell in the embryo and multipotent which can give rise into the cell types of tissues they belong to. Stem cells can also be categorized as embryonic or adult. Embryonic stem cells can be isolated from blastocysts whereas adult stem cells can be obtained from the umblical cord blood and all tissues of mature organs such as the adipose tissue, cornea, teeth and skin. Moreover, recent studies have shown that are stem cells in cancer tissue. [1,2] Stem cells can be isolated from the inner cell mass of blastocyst or on the basis of their adhesive properties in the mature tissue. They can be sorted by immunosurgery with their affinity to antibodies or just with their ability to stick mechanically. Embryonic stem cells can survive and proliferate on a fibroblast feeder layer in an appropriate culture environment. The function of feeder layer is to provide matrix environment for embryonic stem cells. This environment can also be found as an artificial product like matrigel. Embryonic stem cells can be sorted by drop culture and differentiated to any desirable cell. Proliferation of these cells can be induced by factors like LIF, tyrosine kinases JAK, transcription factors for example STAT or other related agents. Embryonic stem cells can also be identified with alkaline phosphatase activity or high-level telomerase activity. They are also positive for SSEA, TRA-1 osteopontin and PCAM-1 factors. Transcription factors such as Oct4, Sox2, FoxD3, Fbx15, Nanog, Fgf4, Utf1, Rex-1, Tdgf-1 can also be useful for their description. [3] Mesenchymal Stem CellsMesenchymal stem cells can be sorted with their adhesive capacity to stick to plastic culture dish (Figure 1a). These cells on tissue culture plate can migrate, proliferate and expand. Using different medium and growth fac-

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“…Given the limited regenerative capacity of heart muscle, stem cell‐based therapies have the potential to transform the treatment of heart failure through myocardial regeneration . Current status of stem cell therapy for heart failure has been reported with several clinical trials performed to date. As previously reviewed, stem cell therapy is known to improve perfusion and contractility in ischemic heart tissue though efficacy is limited by delivery efficiency, engraftment, and survival of these cells .…”

mentioning

confidence: 99%