Combined use of Vitamins E and C improve nephrotoxicity induced by colistin in rats

Ghlissi, Zohra; Hakim, Ahmed; Mnif, Héla; Zeghal, Khaled Mounir; Rebaï, Tarek; Boudawara, T.; Sahnoun, Zouheir

doi:10.4103/1319-2442.235168

Cited by 14 publications

(9 citation statements)

References 2 publications

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“…6 In this context, we compared the extent of oxidative stress among the groups that were previously first analyzed, and it was found that there were significant increases in the levels of MDA and SOD activity within the CMStreated group as compared to the control groups, which were in keeping with previous studies. 23,24,[34][35][36][37][38][39] However, ALA administration did not significantly affect their levels. These findings were also parallel to the TOS level, which was analyzed to evaluate the total oxidant status, including other species such as reactive nitrogen species and ROS.…”

Section: Discussionmentioning

confidence: 85%

Alpha-lipoic acid alleviates colistin nephrotoxicity in rats

et al. 2020

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Colistin methanesulfonate (CMS), a clinical form of colistin, is widely used as a last-line treatment for multidrug-resistant (MDR) gram-negative bacterial infections in critically ill patients presenting a considerably high mortality rate. However, nephrotoxicity is considered to be a critical adverse effect that limits CMS’s clinical use. Alpha-lipoic acid (ALA) is a strong antioxidant that is effective in preventing nephrotoxicity in many models. The aim of this study was to investigate ALA’s ability to protect against nephrotoxicity induced by colistin in rats. Male Wistar albino rats were randomly divided into four groups. Group 1 was the control group (Control; n = 6), in which isotonic saline was administered to the rats. Group 2 was the ALA group (ALA; n = 6) in which rats received 100 mg/kg ALA. Groups 3 was the CMS (CMS; n = 7) in which 450.000 IU/kg/day of CMS was administered to the rats. Groups 4 was the CMS + ALA group (n = 6), in which rats were injected with 100 mg/kg of ALA 30 min before administration of CMS. All injections were performed intraperitoneally at 1, 4, 7, and 10 days. Urine was collected by using a metabolic cage for 24 h after each administration. The rats were euthanized under ether anesthesia after 24 h of the last administration. Blood and kidney samples then were collected for histological and biochemical analysis. ALA pretreatment could reverse the effects of colistin-induced nephrotoxicity, partly through its suppressing effect on Nox4 and caspase-3, which in turn results in its antioxidant and antiapoptotic effect. Therefore, ALA may be an effective strategy for the management of colistin nephrotoxicity.

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Section: Discussionmentioning

confidence: 85%

Alpha-lipoic acid alleviates colistin nephrotoxicity in rats

et al. 2020

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“…CMS in twice daily doses for 7 days PCr, UCr, urine GGT, MDA, SOD, CAT, GPx, GSH, renal histology Attenuated PCr and urine GGT levels and partially diminished the degree of colistin-induced renal damage [ 129 ] Vitamin E Rats 100 mg/kg/day for 2 weeks after colistin discontinuation 300,000 and 450,000 IU/kg/day of I.M. CMS in twice daily doses for 7 days PCr, UCr, urine NAG, MDA, SOD, GSH, renal histology Attenuated increased NAG and MDA levels, attenuated decreased SOD and GSH activities, and improved tubular regeneration [ 43 ] Vitamin E + Vitamin C Rats 100 mg/kg/day given by oral gavages for 7 days 450,000 IU/kg/day of CMS for 7 days Urine NAG, urine GGT, PCr, plasma level of vitamins E and C, MDA, SOD, CAT, GPx, renal histology Restored all biochemical parameters (increased NAG GGT and MDA and decreased the plasma levels of vitamin E and C, SOD, CAT, and GPx, and improved histopathological damage [ 133 ] Vitamin E Humans 400 mg vitamin E in form of alpha tocopherol daily – – – [ 134 ] …”

Section: Methodsmentioning

confidence: 99%

“…The findings demonstrated that the co-administration of vitamins E and C (at 100 mg/kg each) could improve the histopathological damage and restore all the mentioned biochemical parameters. The authors concluded that the combination therapy of vitamins E and C had a better antioxidant effect against colistin-induced tubular damage than either of the two vitamins given alone, which was attributed to their different subcellular locations as well as to their synergistic action [ 134 ].…”

Section: Methodsmentioning

confidence: 99%

Pharmacological agents for the prevention of colistin-induced nephrotoxicity

2022

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Background Colistin is a polymyxin antibiotic which has been used for treatment of Gram-negative infections, but it was withdrawn due to its nephrotoxicity. However, colistin has gained its popularity in recent years due to the reemergence of multidrug resistant Gram-negative infections and drug-induced toxicity is considered as the main obstacle for using this valuable antibiotic. Results In total, 30 articles, including 29 animal studies and one clinical trial were included in this study. These compounds, including aged black garlic extract, albumin fragments, alpha lipoic acid, astaxanthin, baicalein, chrysin, cilastatin, colchicine, curcumin, cytochrome c, dexmedetomidine, gelofusine, grape seed proanthocyanidin extract, hesperidin, luteolin, lycopene, melatonin, methionine, N-acetylcysteine, silymarin, taurine, vitamin C, and vitamin E exhibited beneficial effects in most of the published works. Conclusions In this review, the authors have attempted to review the available literature on the use of several compounds for prevention or attenuation of colistin-induced nephrotoxicity. Most of the studied compounds were potent antioxidants, and it seems that using antioxidants concomitantly can have a protective effect during the colistin exposure.

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“…[ 9 ] In the study of Ghlissi et al ., concomitant use of vitamins E and C with colistin in rats reduced renal tubular damage. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

“…Due to the involvement of oxidative reactions in the pathogenesis of colistin nephrotoxicity, antioxidant agents possibly have the potential to reduce this complication. Animal studies have indicated the beneficial effects of some antioxidants such as melatonin,[ 9 ] Vitamins E and C,[ 10 ] lycopene,[ 11 ] and astaxanthin[ 12 ] in reducing colistin-induced kidney injury.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effectiveness of N-Acetylcysteine in the Prevention of Colistin-Induced Nephrotoxicity

Mosayebi

Soltani

Shafiee

et al. 2021

Journal of Research in Pharmacy Practice

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Objective: The present study aimed to evaluate the effectiveness of N-Acetylcysteine (NAC), as an antioxidant, in preventing nephrotoxicity in patients receiving colistin. Methods: In a randomized controlled clinical trial, eligible participants receiving colistin were divided into two groups including drug ( n = 43) and control ( n = 39). In the drug group, 1200 mg of NAC was administered daily for 10 days concurrently with colistin. Patients in the control group received only colistin. The serum creatinine level (SCr), blood urea nitrogen (BUN), and creatinine clearance (CrCl) at baseline and every other day, and the number of cases with acute kidney injury (AKI) during the study were recorded. Before starting treatment and on day 5, the level of urinary neutrophil gelatinase-associated lipocalin (NGAL) was determined. Finally, the values were compared between the groups. Findings: There was a significant increase in SCr and BUN and a significant reduction in CrCl in both groups, but there was not any significant difference between the two groups at any time. Changes in the urine NGAL levels were not significantly different between the two groups. Even though the number of cases with AKI in the drug group (8 cases, 18.6%) was less than the control group (11 cases, 28.2%), the difference was not statistically significant ( P = 0.303). Conclusion: Simultaneous administration of NAC with a dose of 1200 mg daily does not have any effect in the prevention of colistin-induced nephrotoxicity.

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Combined use of Vitamins E and C improve nephrotoxicity induced by colistin in rats

Cited by 14 publications

References 2 publications

Alpha-lipoic acid alleviates colistin nephrotoxicity in rats

Alpha-lipoic acid alleviates colistin nephrotoxicity in rats

Pharmacological agents for the prevention of colistin-induced nephrotoxicity

Evaluation of the Effectiveness of N-Acetylcysteine in the Prevention of Colistin-Induced Nephrotoxicity

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