Combined Used of Rheology and LF-NMR for the Characterization of PVP-Alginates Gels Containing Liposomes

Fanesi, Giulia; Abrami, Michela; Zecchin, Francesca; Giassi, Irina; Ferro, Elena Dal; Boisen, Anja; Grassi, Gabriele; Bertoncin, Paolo; Marizza, Paolo

doi:10.1007/s11095-018-2427-0

Cited by 20 publications

(15 citation statements)

References 37 publications

(37 reference statements)

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“…This is because the conventional methods were based on three common assumptions that are: (1) no-slippage on the boundary; (2) homogeneous velocity profile of the bulk during shear; (3) relaxation upon shear cessation occurring without the emergence of macroscopic motion due to shear history [86]. Guilia Fanesi et al (2018) demonstrated the potentiality of using rheology and low-frequency magnetic resonance imaging for the characterization of hydrogels [87].…”

Section: Properties and Structurementioning

confidence: 99%

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

et al. 2019

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The field of regenerative medicine has tremendous potential for improved treatment outcomes and has been stimulated by advances made in bioengineering over the last few decades. The strategies of engineering tissues and assembling functional constructs that are capable of restoring, retaining, and revitalizing lost tissues and organs have impacted the whole spectrum of medicine and health care. Techniques to combine biomimetic materials, cells, and bioactive molecules play a decisive role in promoting the regeneration of damaged tissues or as therapeutic systems. Hydrogels have been used as one of the most common tissue engineering scaffolds over the past two decades due to their ability to maintain a distinct 3D structure, to provide mechanical support for the cells in the engineered tissues, and to simulate the native extracellular matrix. The high water content of hydrogels can provide an ideal environment for cell survival, and structure which mimics the native tissues. Hydrogel systems have been serving as a supportive matrix for cell immobilization and growth factor delivery. This review outlines a brief description of the properties, structure, synthesis and fabrication methods, applications, and future perspectives of smart hydrogels in tissue engineering.

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Section: Properties and Structurementioning

confidence: 99%

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

et al. 2019

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“…LF-NMR characterization implies the introduction of a 1-2 mL of blend in NMR tube, then analysis proceeds and the output consist in the magnetization decay (I(t)) due to the magnetic relaxation of hydrogens belonging to water molecules contained in the sample. Then, I(t) is fitted by means of a sum of decaying exponentials, each one characterized by a different time decay constant (T 2i ) and weight (A i ) (Abrami et al, 2018;Fanesi et al, 2018):…”

Section: Lf-nmr Measurementsmentioning

confidence: 99%

“…(A.1) and (A.2) in Appendix A. Another non-ideal feature of hydrogels, which is not considered in the equation Peppas-Merrill, is spatial gel inhomogeneity, as hydrogels always exhibit an inhomogeneous crosslink density distribution (Abrami et al, 2018;Fanesi et al, 2018). While crosslink density of hydrogels can be described by rheological measurements, the gel inhomogeneity can be effectively determined by LF-NMR analysis (Fanesi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide-based hydrogels crosslink density equation: A rheological and LF-NMR study of polymer-polymer interactions

Kopač

Abrami

Grassi

et al. 2022

Carbohydrate Polymers

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Na-Alg/PVP NMR, CLSM, TEM, DLS optimize IPN hydrogels devoted to the release of active agents. [59] Na-Alg/Fenugreek seeds/Psyllium Seed PCR, OM enhancement of probiotic bacterial growth in the gastrointestinal environment. [60] Na-Alg/methylcellulose Hmsc, SEM, CLSM improve the functionality of the plotted cell-matrix constructs.…”

Section: Blends and Composite Of Na-algmentioning

confidence: 99%

A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

et al. 2021

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Sodium alginate (Na-Alg) is water-soluble, neutral, and linear polysaccharide. It is the derivative of alginic acid which comprises 1,4-β-d-mannuronic (M) and α-l-guluronic (G) acids and has the chemical formula (NaC6H7O6). It shows water-soluble, non-toxic, biocompatible, biodegradable, and non-immunogenic properties. It had been used for various biomedical applications, among which the most promising are drug delivery, gene delivery, wound dressing, and wound healing. For different biomedical applications, it is used in different forms with the help of new techniques. That is the reason it had been blended with different polymers. In this review article, we present a comprehensive overview of the combinations of sodium alginate with natural and synthetic polymers and their biomedical applications involving delivery systems. All the scientific/technical issues have been addressed, and we have highlighted the recent advancements.

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Combined Used of Rheology and LF-NMR for the Characterization of PVP-Alginates Gels Containing Liposomes

Cited by 20 publications

References 37 publications

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

Polysaccharide-based hydrogels crosslink density equation: A rheological and LF-NMR study of polymer-polymer interactions

A Critical Review on the Synthesis of Natural Sodium Alginate Based Composite Materials: An Innovative Biological Polymer for Biomedical Delivery Applications

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