2021
DOI: 10.1111/phpp.12753
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Combined versus conventional photodynamic therapy with 5‐aminolaevulinic acid nanoemulsion (BF‐200 ALA) for actinic keratosis: A randomized, single‐blind, prospective study

Abstract: Background: Photodynamic therapy (PDT) has become one of the most effective therapies for the treatment of actinic keratosis, allowing the removal of more than one lesion in a single session. However, the pain sustained by the patient during treatment and local skin reactions can limit its use. Objectives:To determine the efficacy and safety of combined PDT (daylight PDT followed by conventional PDT) vs conventional PDT 12 weeks after treatment. Methods:The study was performed as a randomized, single-center, n… Show more

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Cited by 3 publications
(3 citation statements)
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“…4 Continuous activation of low levels of PpIX using shorter incubation times, lower irradiance, and daylight or combined PDT may decrease pain without loss of efficacy in AK. 15,16,19,20 However, few modifications to conventional ALA-PDT protocols have been rigorously evaluated in clinical trials, and even fewer are backed by FDA approval. Larger, randomized, controlled studies, particularly those evaluating daylight and combination PDT, are needed to standardize these protocols, strengthen the evidence base, and support reimbursement in AK and other indications.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…4 Continuous activation of low levels of PpIX using shorter incubation times, lower irradiance, and daylight or combined PDT may decrease pain without loss of efficacy in AK. 15,16,19,20 However, few modifications to conventional ALA-PDT protocols have been rigorously evaluated in clinical trials, and even fewer are backed by FDA approval. Larger, randomized, controlled studies, particularly those evaluating daylight and combination PDT, are needed to standardize these protocols, strengthen the evidence base, and support reimbursement in AK and other indications.…”
Section: Discussionmentioning
confidence: 99%
“…Both PDT-associated pain and the severity of erythema and edema were significantly lower in patients who received combined vs conventional PDT (Table 1). 20 The primary advantage of daylight PDT is the near painlessness of the procedure. Furthermore, use of the sun as a light source is free of cost and saves clinic space and time.…”
Section: Ala Formulationmentioning
confidence: 99%
“…It has been mostly used in the treatment of actinic keratosis, basal cell skin cancer, cutaneous T-cell lymphoma, etc. [50][51][52][53].…”
Section: Photodynamic Therapymentioning
confidence: 99%