Combining Artesunate-Amodiaquine and Ciprofloxacin Improves Serum Lipid Profile of Mice Exposed to Plasmodium Berghei Berghei

Uwah, Anthony Fidelis; Ndem, Jessie Idongesit; Akpan, Effiong Ekong

doi:10.7439/ijbr.v5i8.683

Cited by 3 publications

(3 citation statements)

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“…They reported that fresh tubers weight, tubers weight marketable, and tubers productivity was significantly higher than that of control (50 kg potassium/ha). In Nigeria, Uwah et al [9] reported that application of 120 kg potassium fertilizer/ha on cassava improved tubers weight and tubers productivity around 48% and 36%, respectively. The heavier RW of UJ3 was supported by the increase in TRN, RN, DRD, and RL.…”

Section: Resultsmentioning

confidence: 99%

Improved cassava (Manihot esculenta Crantz) growth and production by application of potassium

Sungkono,

Setiawan,

Fatah

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Indonesia is the fifth countries in term of cassava production in the world. The biggest cassava area in Indonesia is Lampung. One of the important nutrient fertilizers to improve cassava production is potassium. Consequently, the objective of this study was to evaluate distribution of photoassimilate by determining cassava growth and production under different potassium dosages. Treatment was arranged by factorial (2x3) in randomized complete block design (RCBD) with two reps. The first factor was two cassava clones, UJ3 and UJ5 and the second factor was three potassium (KCl) dosages, 0, 150, and 300 kg/ha. The variables observed in this study were plant height, stem diameter, fresh weight and dry weight of leaf, total root number and swollen root number, distribution of root number, root length, root distribution, and root weight. The result showed that under fertilizer of 300 kg KCl/ha, stem dry weight of UJ3 and UJ5 was not significantly different however root fresh weight of UJ3 seemed higher compared to that of UJ5. It seems that UJ3 cassava clone is more responsive to potassium fertilizer than UJ5 cassava clone.

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Section: Resultsmentioning

confidence: 99%

Improved cassava (Manihot esculenta Crantz) growth and production by application of potassium

Sungkono,

Setiawan,

Fatah

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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“…Co-infection of malaria parasite and Salmonella species is also common in Nigeria, and anti-malarial drugs in combination with antibiotics especially ciprofloxacin are frequently administered concomitantly without adequate laboratory diagnoses for both diseases. There is a report that co-administration of artemisinin/artemisinin derivatives and ciprofloxacin is a common practice in the South-South region of Nigeria in the treatment of malaria [11]. Clinically, important interactions may occur between antimalarial drugs and ciprofloxacin compromising or potentiating the treatment of either infection.…”

Section: Introductionmentioning

confidence: 99%

Assessing the effect of concomitant administration of artemether-lumefantrine and ciprofloxacin on some cardiac parameters in Wistar rats: “The remedial role of vitamin E”

Ndem¹,

Sylvanus²,

Bassey³

et al. 2021

GSC Biol. and Pharm. Sci.

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The effect of Vitamin E on some cardiac parameters following concomitant administration of artemether-lumefantrine (AL) and ciprofloxacin in male Wistar rats was investigated. Thirty-five male Wistar rats weighing between 190 – 220 g, used for the study were randomly divided into seven groups of five animals each. Group I served as the control. Group II - VII were administered; 8 mg/kg body weight (bw) of AL; 7.14 mg/kg bw of Ciprofloxacin; 8 mg/kg bw of AL + 7.14 mg/kg bw of Ciprofloxacin; 8 mg/kg bw of AL + 8.57 IU of Vitamin E; 7.14 mg/kg bw of Ciprofloxacin + 8.57 IU of Vitamin E; and 8 mg/kg bw of AL + 7.14 mg/kg bw of Ciprofloxacin + 8.57 IU of Vitamin E respectively. All the drugs were administered at their therapeutic regimen. Some cardiac parameters investigated include lipid profile, Troponin I, Troponin T, Creatine kinase, Lactate dehydrogenase and aspartate aminotransferase. The result showed significant (p < 0.05) increase in all the parameters of cardiac function when treatment groups were compared with control. The observed increase in cardiac indices were however significantly (p < 0.05) ameliorated in Groups V, VII and VII which were co-administered with Vitamin E compared with Groups II, III and IV which received the test drugs independently. The weights of the heart tissues showed the same trend with the parameters of cardiac function assessed and upon administration of vitamin E. The results obtained suggest the antioxidative role of vitamin E in alleviating the negative effects induced by artemether-lumefantrine and ciprofloxacin combination treatment, which may be from the impact of free radicals that may have been generated by the combined drugs.

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“…The co-administration of ACTs derivatives and ciprofloxacin is a common practice in Nigeria in the treatment of malaria and enteric fever co-infection 12 . Ciprofloxacin inhibits CYP1A2 and have been reported to increase plasma theophylline levels.…”

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confidence: 99%

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2016

IJPSR

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This study evaluates the effect of ciprofloxacin (CIP) on the antimalarial activity of artesunate (AS), artemether-lumefantrine (AL) and artesunate-amodiaquine using animal model. Some 120 albino mice infected with chloroquine sensitive Plasmodium berghei NK65 strain were used. The study was carried out in three phases. Phase 1 consisted of eleven groups treated with different doses of either AS, AL, ASAQ or CIP alone. Phase 2 consisted of nine groups treated with 7 mg/kg of CIP (CIP1) combined with different doses of AS, AL, ASAQ. Phase 3 consist of ten groups treated with 14 mg/kg of CIP (CIP2) with different doses of AS, AL, ASAQ. Thin blood films were used to assess parasitemia level daily after administration of drugs for 72 h. Results were analyzed using student t-test and analysis of variance (ANOVA). CIP alone showed antimalarial activity with 63 % parasitemia reduction. Antimalarial activities of AS and AL were significantly enhanced by both 7 and 14 mg/kg of CIP. The antimalarial effect of ASAQ was enhanced but not statistically significant. Low dose ciprofloxacin significantly enhanced the antimalarial activities of Artesunate, ArtemetherLumefanthrine and Artesunate-Amodiaquine This combination may be beneficial in the management of Plasmodium falciparum infection or coinfection with salmonellosis.

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Combining Artesunate-Amodiaquine and Ciprofloxacin Improves Serum Lipid Profile of Mice Exposed to Plasmodium Berghei Berghei

Cited by 3 publications

References 11 publications

Improved cassava (Manihot esculenta Crantz) growth and production by application of potassium

Improved cassava (Manihot esculenta Crantz) growth and production by application of potassium

Assessing the effect of concomitant administration of artemether-lumefantrine and ciprofloxacin on some cardiac parameters in Wistar rats: “The remedial role of vitamin E”

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