Combining atomic force microscopy with complementary techniques for multidimensional single‐cell analysis

Li, Mi

doi:10.1111/jmi.13183

Cited by 4 publications

(1 citation statement)

References 214 publications

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“…Various techniques have been developed for the enrichment and isolation of CTCs from the blood (Ferreira et al, 2016), and therefore combining AFM with these techniques will yield novel insights into the mechanical properties of CTCs and how they regulate tumor metastasis. Particularly, AFM is highly compatible and can be integrated with many other complementary techniques for multidimensional single‐cell analysis (Li, 2023c), and thus combining AFM with complementary techniques to detect the mechanical properties of CTCs will further benefit comprehensively understanding the functional role of mechanics in cancer biology.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Harnessing atomic force microscopy‐based single‐cell analysis to advance physical oncology

2023

Microscopy Res & Technique

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Single‐cell analysis is an emerging and promising frontier in the field of life sciences, which is expected to facilitate the exploration of fundamental laws of physiological and pathological processes. Single‐cell analysis allows experimental access to cell‐to‐cell heterogeneity to reveal the distinctive behaviors of individual cells, offering novel opportunities to dissect the complexity of severe human diseases such as cancers. Among the single‐cell analysis tools, atomic force microscopy (AFM) is a powerful and versatile one which is able to nondestructively image the fine topographies and quantitatively measure multiple mechanical properties of single living cancer cells in their native states under aqueous conditions with unprecedented spatiotemporal resolution. Over the past few decades, AFM has been widely utilized to detect the structural and mechanical behaviors of individual cancer cells during the process of tumor formation, invasion, and metastasis, yielding numerous unique insights into tumor pathogenesis from the biomechanical perspective and contributing much to the field of cancer mechanobiology. Here, the achievements of AFM‐based analysis of single cancer cells to advance physical oncology are comprehensively summarized, and challenges and future perspectives are also discussed.Research Highlights Achievements of AFM in characterizing the structural and mechanical behaviors of single cancer cells are summarized, and future directions are discussed. AFM is not only capable of visualizing cellular fine structures, but can also measure multiple cellular mechanical properties as well as cell‐generated mechanical forces. There is still plenty of room for harnessing AFM‐based single‐cell analysis to advance physical oncology.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Harnessing atomic force microscopy‐based single‐cell analysis to advance physical oncology

2023

Microscopy Res & Technique

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A review of innovative electrochemical strategies for bioactive molecule detection and cell imaging: Current advances and challenges

Zhang,

Jiang,

Liu

et al. 2024

Analytica Chimica Acta

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Unveiling the Microplastics Menace: A Bibliometric Analysis from 2011 to 2023

Achoukhi,

El Hammoudani,

Haboubi

et al. 2024

BIO Web Conf.

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The escalating production of Microplastics in marine environments has become a critical environmental issue. This in-depth study examines the worrying issue of microplastic pollution in aquatic environments, revealing notable gaps in the literature and presenting significant research opportunities. Microplastics, derived from the degradation of plastic waste, represent a major challenge for aquatic ecosystems due to their ease of ingestion by wildlife, with common polymers as the main sources. Major pathways of introduction include urban wastewater discharges and the mass disposal of plastic waste. Bioaccumulation, effects on marine ecosystems and identification techniques are areas requiring further exploration. At the same time, the increasing production of microplastics in marine environments is a critical environmental issue. Bibliometric analysis reveals key themes, including sources, production pathways, ecological impacts, and mitigation strategies. This research not only highlights current concerns, but also identifies emerging topics such as advanced monitoring technologies and sustainable production alternatives. Together, these findings offer crucial insights to guide future investigations aimed at mitigating the growing challenges associated with microplastic production in marine ecosystems.

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Combining atomic force microscopy with complementary techniques for multidimensional single‐cell analysis

Cited by 4 publications

References 214 publications

Harnessing atomic force microscopy‐based single‐cell analysis to advance physical oncology

Harnessing atomic force microscopy‐based single‐cell analysis to advance physical oncology

A review of innovative electrochemical strategies for bioactive molecule detection and cell imaging: Current advances and challenges

Unveiling the Microplastics Menace: A Bibliometric Analysis from 2011 to 2023

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