Combining biochemical and ultrasonographic markers in predicting preeclampsia: a systematic review

Giguère, Yves; Charland, Marc; Bujold, Emmanuel; Bernard, Nathalie; Grenier, Sonya; Rousseau, François; Lafond, Julie; Forest, Jean‐Claude

doi:10.1684/abc.2011.0572

Cited by 40 publications

(48 citation statements)

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“…Bolin et al [12] demonstrated that separate measurements of serum HRG and PI may predict pre-eclampsia, but by combining serum HRG and PI the accuracy increased. This is in line with this study in which a total accuracy of both reached 84.3% and in line with studies proposing a combination of biochemical and biophysical markers for a successful prediction of pre-eclampsia in early pregnancy [13,14,22,23].…”

Section: Figuresupporting

confidence: 92%

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The combination of histidine-rich glycoprotein and uterine artery Doppler velocimetry in the prediction of pre-eclampsia

Bassiouny¹,

El-Said²,

Mohamed³

et al. 2016

Evidence Based Womenʼs Health Journal

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ObjectivePre-eclampsia is accompanied by both maternal and neonatal complications. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory reactions, which are involved in the development of pre-eclampsia. We assessed the value of combining early second trimester maternal serum HRG and uterine artery Doppler in predicting pre-eclampsia. Patients and methods A total of 140 pregnant women were divided into two groups: group A (n = 70), a high-risk group, and group B (n = 70), a control group. They were subjected to measurement of maternal serum HRG at 16-18 weeks of gestation and uterine artery Doppler assessment at 20-22 weeks of gestation. All pregnancies were followed up until delivery for development of pre-eclampsia. ResultsThe cases that developed pre-eclampsia had lower serum levels of HRG and higher pulsatility index. Our cutoff value for serum HRG to predict pre-eclampsia was less than 40.6 mg/ml and the cutoff value for mean pulsatility index was less than 1.24. The sensitivity, specificity, positive predictive value, negative predictive value, and total accuracy of uterine artery Doppler combined with serum HRG for pre-eclampsia prediction were 71.4, 97.1, 96.1, 77.3, and 84.3%, respectively. Conclusion This combination test may be a useful early second trimester screening test for the prediction of pre-eclampsia.

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Section: Figuresupporting

confidence: 92%

“…Uterine artery Doppler ultrasonography is one of the best predictors of pre-eclampsia [13]. Doppler assessment of the uterine arteries is a noninvasive test suggested to reflect trophoblast invasion and development, as well as uteroplacental perfusion [14].…”

Section: Introductionmentioning

confidence: 99%

The combination of histidine-rich glycoprotein and uterine artery Doppler velocimetry in the prediction of pre-eclampsia

Bassiouny¹,

El-Said²,

Mohamed³

et al. 2016

Evidence Based Womenʼs Health Journal

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“…The most effective predictive models for pre-eclampsia have combined serum biomarker analysis with uterine artery waveform analysis and maternal demographic features (148). Sensitivities and specificities greater than 90% have been reported from retrospective analysis of serum levels of placental growth factor, pregnancy associated peptide A or placental protein 13 from samples collected in the first trimester with uterine artery Doppler and demographic data (148,150,155) but are yet to be validated in prospective cohorts.…”

Section: Discussionmentioning

confidence: 99%

Disentangling the effects of climate, topography, soil and vegetation on stand-scale species richness in temperate forests

Zellweger

Braunisch

Morsdorf

et al. 2015

Forest Ecology and Management

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“…Placental protein 13 (PP13) is a serum marker of placental origin that is widely used to monitor the development of pregnancy [8,13,31]. The protein, also known as galectin 13, is exclusively produced in the syncytiotrophoblast layer of the placenta, from where it reaches the maternal blood circulation from as early as the 6 th week of gestation [3,17].…”

Section: Introductionmentioning

confidence: 99%

First trimester maternal serum placental protein 13 levels in singleton vs. twin pregnancies with and without severe pre-eclampsia

Svirsky

Meiri²,

Herzog³

et al. 2013

Journal of Perinatal Medicine

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Combining biochemical and ultrasonographic markers in predicting preeclampsia: a systematic review

Cited by 40 publications

References 0 publications

The combination of histidine-rich glycoprotein and uterine artery Doppler velocimetry in the prediction of pre-eclampsia

The combination of histidine-rich glycoprotein and uterine artery Doppler velocimetry in the prediction of pre-eclampsia

Disentangling the effects of climate, topography, soil and vegetation on stand-scale species richness in temperate forests

First trimester maternal serum placental protein 13 levels in singleton vs. twin pregnancies with and without severe pre-eclampsia

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