2023
DOI: 10.1007/s00424-023-02853-5
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Combining different ion-selective channelrhodopsins to control water flux by light

Fei Lin,
Ruijing Tang,
Chong Zhang
et al.

Abstract: Water transport through water channels, aquaporins (AQPs), is vital for many physiological processes including epithelial fluid secretion, cell migration and adipocyte metabolism. Water flux through AQPs is driven by the osmotic gradient that results from concentration differences of solutes including ions. Here, we developed a novel optogenetic toolkit that combines the light-gated anion channel GtACR1 either with the light-gated K+ channel HcKCR1 or the new Na+ channelrhodopsin HcNCR1 with high Na+ permeabil… Show more

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