Combining ergometer exercise and artificial gravity in a compact-radius centrifuge

Diaz, Ana; Trigg, Chris; Young, Laurence R.

doi:10.1016/j.actaastro.2015.03.034

Cited by 21 publications

(15 citation statements)

References 5 publications

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“…Consequently, interest has shifted toward SAHC as a training tool to minimize microgravity-induced physiological deconditioning ( Clément and Pavy-Le Traon, 2004 ). SAHC, given its capability to create artificial gravity and has a potential to produce hydrostatic gradients analogous to standing and evoke multiple physiological systems simultaneously ( Zander et al, 2013 ; Diaz et al, 2015 ). Achieving desired performance from SAHC, however, is contingent on an ideal choice of g-load.…”

Section: Discussionmentioning

confidence: 99%

“…The short-arm human centrifuge (SAHC), in this regard, can serve as a promising training tool ( Evans et al, 2004 ; Frett et al, 2014 ; Clément et al, 2015 ). The feasibility of short-arm centrifuge to be a part of a long duration spaceflight, owing to compact modern design, has opened new avenues toward minimizing the severity of microgravity-induced systemic deconditioning ( Bukley et al, 2007 ; Zander et al, 2013 ; Frett et al, 2014 ; Diaz et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge

Verma

Bruner

et al. 2018

Front. Physiol.

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Autonomic control of blood pressure is essential toward maintenance of cerebral perfusion during standing, failure of which could lead to fainting. Long-term exposure to microgravity deteriorates autonomic control of blood pressure. Consequently, astronauts experience orthostatic intolerance on their return to gravitational environment. Ground-based studies suggest sporadic training in artificial hypergravity can mitigate spaceflight deconditioning. In this regard, short-arm human centrifuge (SAHC), capable of creating artificial hypergravity of different g-loads, provides an auspicious training tool. Here, we compare autonomic control of blood pressure during centrifugation creating 1-g and 2-g at feet with standing in natural gravity. Continuous blood pressure was acquired simultaneously from 13 healthy participants during supine baseline, standing, supine recovery, centrifugation of 1-g, and 2-g, from which heart rate (RR) and systolic blood pressure (SBP) were derived. The autonomic blood pressure regulation was assessed via spectral analysis of RR and SBP, spontaneous baroreflex sensitivity, and non-linear heart rate and blood pressure causality (RR↔SBP). While majority of these blood pressure regulatory indices were significantly different (p < 0.05) during standing and 2-g centrifugation compared to baseline, no change (p > 0.05) was observed in the same indices during 2-g centrifugation compared to standing. The findings of the study highlight the capability of artificial gravity (2-g at feet) created via SAHC toward evoking blood pressure regulatory controls analogous to standing, therefore, a potential utility toward mitigating deleterious effects of microgravity on cardiovascular performance and minimizing post-flight orthostatic intolerance in astronauts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge

Verma

Bruner

et al. 2018

Front. Physiol.

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“…The experiments were conducted using the Compact-Radius Centrifuge (CRC) at the Massachusetts Institute of Technology (MIT) ( Diaz et al, 2015b ). Prior to the study, the centrifuge underwent several modifications, primarily driven by the international flight project “Artificial Gravity with Ergometer Exercise” (AGREE) ( Diaz et al, 2015b ). This project sought to integrate a short-radius centrifuge with an ergometer exercise device for possible deployment in the Permanent Multipurpose Module (PPM) on-board the International Space Station (ISS).…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Subjects were secured using a three-point seat-belt and monitored continuously using a wireless video camera. A detailed description of the CRC MIT centrifuge configuration and subject positioning is available elsewhere ( Diaz et al, 2015a , b ).…”

Section: Experimental Methodsmentioning

confidence: 99%

Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise

2018

Self Cite

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Artificial gravity (AG) has often been proposed as an integrated multi-system countermeasure to physiological deconditioning associated with extended exposure to reduced gravity levels, particularly if combined with exercise. Twelve subjects underwent short-radius centrifugation along with bicycle ergometry to quantify the short-term cardiovascular response to AG and exercise across three AG levels (0 G or no rotation, 1 G, and 1.4 G; referenced to the subject’s feet and measured in the centripetal direction) and three exercise intensities (25, 50, and 100 W). Continuous cardiovascular measurements were collected during the centrifugation sessions using a non-invasive monitoring system. The cardiovascular responses were more prominent at higher levels of AG and exercise intensity. In particular, cardiac output, stroke volume, pulse pressure, and heart rate significantly increased with both AG level (in most of exercise group combinations, showing averaged increments across exercise conditions of 1.4 L/min/g, 7.6 mL/g, 5.22 mmHg/g, and 2.0 bpm/g, respectively), and workload intensity (averaged increments across AG conditions of 0.09 L/min/W, 0.17 mL/W, 0.22 mmHg/W, and 0.74 bpm/W respectively). These results suggest that the addition of AG to exercise can provide a greater cardiovascular benefit than exercise alone. Hierarchical regression models were fitted to the experimental data to determine dose-response curves of all cardiovascular variables as a function of AG-level and exercise intensity during short-radius centrifugation. These results can inform future studies, decisions, and trade-offs toward potential implementation of AG as a space countermeasure.

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“…Considering the effect on human body of supergravity fields, researchers have studied the countermeasure. Ana Diaz [6] designed a compact rotating centrifuge to research physiological deconditioning during space missions by making an artificial supergravity. The similar research worked by Yifan Yang [7] showed that artificial gravity is a potential countermeasure against the microgravity in space.…”

Section: Introductionmentioning

confidence: 99%

Research on Morphology of Human Red Blood Cells (RBCs) in Different Gravity Fields

Li¹,

Gao²

2016

Proceedings of the 2016 International Conference on Biological Sciences and Technology

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Abstract. By testing fresh human red blood cells (RBCs), the morphology of human RBCs in different gravity fields was observed by SK2109P microscope. And the death rate of RBCs in different gravity fields were counted Results show that: RBCs can endure a certain gravity field. RBCs barely died under gravity fields less than 340g. The death rate increased from 40% to 70% while the gravity field increased from 1360g to 1850g. When gravity field reached 3050g, the death rate became over 90%, it was hard to find survival cells in viewing field.

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Combining ergometer exercise and artificial gravity in a compact-radius centrifuge

Cited by 21 publications

References 5 publications

Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge

Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge

Short-Term Cardiovascular Response to Short-Radius Centrifugation With and Without Ergometer Exercise

Research on Morphology of Human Red Blood Cells (RBCs) in Different Gravity Fields

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